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Zeitschriftendaten
Format
Zeitschrift
eISSN
1875-855X
Erstveröffentlichung
01 Jun 2007
Erscheinungsweise
6 Hefte pro Jahr
Sprachen
Englisch

Suche

Volumen 12 (2018): Heft 6 (December 2018)

Zeitschriftendaten
Format
Zeitschrift
eISSN
1875-855X
Erstveröffentlichung
01 Jun 2007
Erscheinungsweise
6 Hefte pro Jahr
Sprachen
Englisch

Suche

6 Artikel

Editorial

Uneingeschränkter Zugang

Acute respiratory distress syndrome: continuing challenges

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 243 - 244

Zusammenfassung

Original article

Uneingeschränkter Zugang

Assessing hospital readiness for radio frequency identification device implementation in Iran: a conceptual model

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 245 - 254

Zusammenfassung

Abstract

To avoid possible failures and ineffective use of economic resources, necessary infrastructure must be provided before implementing new technologies in a developing country like Iran.

To assess the degree of readiness for implementing a radio frequency identification device (RFID) system in hospitals in Iran.

We adopted a descriptive design and structural equation modeling (LISREL statistical software package) to analyze data collected from the hospitals affiliated with the Semnan University of Medical Sciences. All managers, physicians, residents, nurses, and staff members of the medical records and information technology sectors participated in this study. A questionnaire was designed by the investigators to collect ideas from the participants about organizational readiness, cultural readiness, and human resource readiness in implementing RFID.

We found a significant positive correlation between the variables studied. Human resource readiness significantly predicted RFID implementation, with cultural readiness playing the role of a mediator variable. Cultural readiness itself was influenced by organizational readiness (P < 0.01). We found 0.346 (standard deviation: 0.374) changes in an arbitrary unit of the possibility of RFID implementation was attributed to human resources and cultural readiness.

Paying attention to cultural factors, which play an important role in implementing technological projects such as RFID in developing countries like Iran, can reduce the risk of failure. Hospitals should strengthen organizational factors and improve the support of top rank managers when implementing technological projects. By so doing, they will promote cultural readiness, prepare human resources, and win the cooperation of personnel for such projects.

Schlüsselwörter

  • health plan implementation
  • latent class analysis
  • radio frequency identification device
  • set (psychology)
Uneingeschränkter Zugang

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 255 - 262

Zusammenfassung

Abstract

Adiponectin secreted by adipocytes plays a key role in insulin sensitivity, anti-inflammation, and antiatherosclerosis. It is involved in several conditions including obesity, type 2 diabetes mellitus, cardiovascular disease, and chronic kidney disease (CKD). Glomerular filtration rate is monitored to indicate the kidney function and CKD progression.

To assess the serum adiponectin levels in individuals with normal and mildly decreased glomerular filtration rate, analyze the association of serum adiponectin with various physical and biological parameters, and test whether serum adiponectin is the risk factor of mildly decreased glomerular filtration rate.

This cross-sectional study was conducted in 172 individuals with 35–60 years of age. Serum samples were collected and divided into two groups, based on estimated glomerular filtration rate (eGFR): 90 with normal eGFR (G1, eGFR ≥90 mL/min/1.73 m2) and 82 with mildly decreased eGFR (G2, eGFR = 60–89 mL/min/1.73 m2). Anthropometric data were recorded. Serum adiponectin was measured by enzyme-linked immunosorbent assay.

Serum adiponectin levels were significantly increased in individuals with mildly decreased eGFR (G2), compared to G1 (8.23 ± 3.26 µg/mL and 6.57 ± 3.24 µg/mL, respectively; P = 0.001). Serum adiponectin was positively associated with age and high-density lipoprotein cholesterol but negatively associated with weight, body mass index, triglyceride, and waist and hip circumferences. Univariate analysis showed that serum adiponectin was significantly correlated with mildly decreased eGFR; however, when adjusting for confounding factors, there were no correlations. Furthermore, multivariate regression analysis showed that individuals at the age of 46–55 years (4.0; 95% CI: 1.9–8.3) and > 55 years (11.4; 95% CI: 3.7–35.5) were significantly correlated with mildly decreased eGFR.

Serum adiponectin was significantly elevated in individuals with mildly decreased eGFR and may be a modulation factor, but was not an independent risk factor for mildly kidney damage. Further study is needed to clarify its potential benefits as monitoring biomarker for CKD progression.

Schlüsselwörter

  • adiponectin
  • chronic
  • glomerular filtration rate
  • renal insufficiency

Brief communication (original)

Uneingeschränkter Zugang

Clinical outcomes of acute respiratory distress syndrome in a university hospital

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 263 - 271

Zusammenfassung

Abstract

Mortality rates of acute respiratory distress syndrome (ARDS) are different, depending on severity, etiology, and management.

To determine 7-day and 28-day mortalities, hospital length of stay (LOS), duration of mechanical ventilation (MV) of ARDS patients, and factors associated with poor outcomes.

A retrospective study was conducted to review the database of ARDS patients admitted in medical intensive care units (ICUs) at a university hospital between 2010 and 2014. The cases were identified by using International Classification of Diseases, 10th Revision (ICD-10) code-J80 ARDS.

Of 266 patients, 11.7%, 44.4%, and 44% fulfilled mild, moderate, and severe ARDS criteria, respectively. The main cause of ARDS was pneumonia. The 7-day and 28-day mortalities, median LOS, and median MV duration were 31.1%, 69.3%, 18, and 11 days, respectively. Pressure control was the most favorite mode, used with average tidal volume (TV) of 8.63 (2.16) mL/kg ideal body weight (IBW). Recruitment maneuver was most frequently used as adjunctive intervention, whereas prone position was applied to 3.75% of the patients. One-third of the patients received neuromuscular blockades. The median 7-day fluid balance was +6,600 mL. The mean PaO2/FiO2 ratio during the first 3 days, cumulative fluid balance on day 3, and average daily calories during the first week were independent predictors for adjusted 7-day mortality, whereas Acute Physiology and Chronic Health Evaluation (APACHE II) score, fluid balance on day 1, cumulative fluid balance, and average daily calories during the first week were independent predictors for adjusted 28-day mortality.

The 28-day mortality of ARDS was high. In addition, TV and fluid balance were greater than protective limits. These findings indicated the potential improvement of ARDS outcomes in our hospital.

Schlüsselwörter

  • acute respiratory distress syndrome
  • intensive care units
  • positive pressure respiration
Uneingeschränkter Zugang

Osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells encapsulated in Thai silk fibroin/collagen hydrogel: a pilot study in vitro

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 273 - 279

Zusammenfassung

Abstract

Silk fibroin (SF) can be processed into a hydrogel. SF/collagen hydrogel may be a suitable biomaterial for bone tissue engineering.

To investigate in vitro biocompatibility and osteogenic potential of encapsulated rat bone marrow-derived mesenchymal stem cells (rat MSCs) in an injectable Thai SF/collagen hydrogel induced by oleic acid–poloxamer 188 surfactant mixture in an in vitro pilot study.

Rat MSCs were encapsulated in 3 groups of hydrogel scaffolds (SF, SF with 0.05% collagen [SF/0.05C], and SF with 0.1% collagen [SF/0.1C]) and cultured in a growth medium and an osteogenic induction medium. DNA, alkaline phosphatase (ALP) activity, and calcium were assayed at periodically for up to 5 weeks. After 6 weeks of culture the cells were analyzed by scanning electron microscopy and energy dispersive spectroscopy.

Although SF hydrogel with collagen seems to have less efficiency to encapsulate rat MSCs, their plateau phase growth in all hydrogels was comparable. Inability to maintain cell viability as cell populations declined over 1–5 days was observed. Cell numbers then plateaued and were maintained until day 14 of culture. ALP activity and calcium content of rat MSCs in SF/collagen hydrogels were highest at day 21. An enhancing effect of collagen combined with the hydrogel was observed for proliferation and matrix formation; however, benefits of the combination on osteogenic differentiation and biomineralization are as yet unclear.

Rat MSCs in SF and SF/collagen hydrogels showed osteogenic differentiation. Accordingly, these hydrogels may serve as promising scaffolds for bone tissue engineering.

Schlüsselwörter

  • collagen
  • fibroins
  • hydrogels
  • mesenchymal stem cells
  • silk
Uneingeschränkter Zugang

Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 281 - 286

Zusammenfassung

Abstract

Vulvar lesion is one of the common gynecologic problems.

To assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).

Pathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.

A total number of 700 patients were included. The proportion of malignant and premalignant lesions in overall vulvar specimens were 16.3% and 8.4%, respectively. Squamous cell carcinoma was the most common malignant vulvar lesion (48.2%), whereas vulvar intraepithelial neoplasia 1 (VIN1) (33.9%) was the most common lesion in the premalignant group. On multivariate analysis, four clinical factors were significantly associated with malignancy risk: increased parity (odds ratio [OR] 1.19, P = 0.010), large tumor size (OR 2.00, P < 0.001), lesion at clitoris (OR 16.67, P = 0.002), and erythematous lesion (OR 2.41, P = 0.026).

The proportion of malignant and premalignant lesions in overall vulvar specimens was 24.7% in KCMH. Increased parity, large tumor size, clitoris-located lesion, and erythematous lesion were associated with increasing malignancy risk.

Schlüsselwörter

  • carcinoma
  • squamous cell
  • vulvar diseases
  • vulvar neoplasms
6 Artikel

Editorial

Uneingeschränkter Zugang

Acute respiratory distress syndrome: continuing challenges

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 243 - 244

Zusammenfassung

Original article

Uneingeschränkter Zugang

Assessing hospital readiness for radio frequency identification device implementation in Iran: a conceptual model

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 245 - 254

Zusammenfassung

Abstract

To avoid possible failures and ineffective use of economic resources, necessary infrastructure must be provided before implementing new technologies in a developing country like Iran.

To assess the degree of readiness for implementing a radio frequency identification device (RFID) system in hospitals in Iran.

We adopted a descriptive design and structural equation modeling (LISREL statistical software package) to analyze data collected from the hospitals affiliated with the Semnan University of Medical Sciences. All managers, physicians, residents, nurses, and staff members of the medical records and information technology sectors participated in this study. A questionnaire was designed by the investigators to collect ideas from the participants about organizational readiness, cultural readiness, and human resource readiness in implementing RFID.

We found a significant positive correlation between the variables studied. Human resource readiness significantly predicted RFID implementation, with cultural readiness playing the role of a mediator variable. Cultural readiness itself was influenced by organizational readiness (P < 0.01). We found 0.346 (standard deviation: 0.374) changes in an arbitrary unit of the possibility of RFID implementation was attributed to human resources and cultural readiness.

Paying attention to cultural factors, which play an important role in implementing technological projects such as RFID in developing countries like Iran, can reduce the risk of failure. Hospitals should strengthen organizational factors and improve the support of top rank managers when implementing technological projects. By so doing, they will promote cultural readiness, prepare human resources, and win the cooperation of personnel for such projects.

Schlüsselwörter

  • health plan implementation
  • latent class analysis
  • radio frequency identification device
  • set (psychology)
Uneingeschränkter Zugang

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 255 - 262

Zusammenfassung

Abstract

Adiponectin secreted by adipocytes plays a key role in insulin sensitivity, anti-inflammation, and antiatherosclerosis. It is involved in several conditions including obesity, type 2 diabetes mellitus, cardiovascular disease, and chronic kidney disease (CKD). Glomerular filtration rate is monitored to indicate the kidney function and CKD progression.

To assess the serum adiponectin levels in individuals with normal and mildly decreased glomerular filtration rate, analyze the association of serum adiponectin with various physical and biological parameters, and test whether serum adiponectin is the risk factor of mildly decreased glomerular filtration rate.

This cross-sectional study was conducted in 172 individuals with 35–60 years of age. Serum samples were collected and divided into two groups, based on estimated glomerular filtration rate (eGFR): 90 with normal eGFR (G1, eGFR ≥90 mL/min/1.73 m2) and 82 with mildly decreased eGFR (G2, eGFR = 60–89 mL/min/1.73 m2). Anthropometric data were recorded. Serum adiponectin was measured by enzyme-linked immunosorbent assay.

Serum adiponectin levels were significantly increased in individuals with mildly decreased eGFR (G2), compared to G1 (8.23 ± 3.26 µg/mL and 6.57 ± 3.24 µg/mL, respectively; P = 0.001). Serum adiponectin was positively associated with age and high-density lipoprotein cholesterol but negatively associated with weight, body mass index, triglyceride, and waist and hip circumferences. Univariate analysis showed that serum adiponectin was significantly correlated with mildly decreased eGFR; however, when adjusting for confounding factors, there were no correlations. Furthermore, multivariate regression analysis showed that individuals at the age of 46–55 years (4.0; 95% CI: 1.9–8.3) and > 55 years (11.4; 95% CI: 3.7–35.5) were significantly correlated with mildly decreased eGFR.

Serum adiponectin was significantly elevated in individuals with mildly decreased eGFR and may be a modulation factor, but was not an independent risk factor for mildly kidney damage. Further study is needed to clarify its potential benefits as monitoring biomarker for CKD progression.

Schlüsselwörter

  • adiponectin
  • chronic
  • glomerular filtration rate
  • renal insufficiency

Brief communication (original)

Uneingeschränkter Zugang

Clinical outcomes of acute respiratory distress syndrome in a university hospital

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 263 - 271

Zusammenfassung

Abstract

Mortality rates of acute respiratory distress syndrome (ARDS) are different, depending on severity, etiology, and management.

To determine 7-day and 28-day mortalities, hospital length of stay (LOS), duration of mechanical ventilation (MV) of ARDS patients, and factors associated with poor outcomes.

A retrospective study was conducted to review the database of ARDS patients admitted in medical intensive care units (ICUs) at a university hospital between 2010 and 2014. The cases were identified by using International Classification of Diseases, 10th Revision (ICD-10) code-J80 ARDS.

Of 266 patients, 11.7%, 44.4%, and 44% fulfilled mild, moderate, and severe ARDS criteria, respectively. The main cause of ARDS was pneumonia. The 7-day and 28-day mortalities, median LOS, and median MV duration were 31.1%, 69.3%, 18, and 11 days, respectively. Pressure control was the most favorite mode, used with average tidal volume (TV) of 8.63 (2.16) mL/kg ideal body weight (IBW). Recruitment maneuver was most frequently used as adjunctive intervention, whereas prone position was applied to 3.75% of the patients. One-third of the patients received neuromuscular blockades. The median 7-day fluid balance was +6,600 mL. The mean PaO2/FiO2 ratio during the first 3 days, cumulative fluid balance on day 3, and average daily calories during the first week were independent predictors for adjusted 7-day mortality, whereas Acute Physiology and Chronic Health Evaluation (APACHE II) score, fluid balance on day 1, cumulative fluid balance, and average daily calories during the first week were independent predictors for adjusted 28-day mortality.

The 28-day mortality of ARDS was high. In addition, TV and fluid balance were greater than protective limits. These findings indicated the potential improvement of ARDS outcomes in our hospital.

Schlüsselwörter

  • acute respiratory distress syndrome
  • intensive care units
  • positive pressure respiration
Uneingeschränkter Zugang

Osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells encapsulated in Thai silk fibroin/collagen hydrogel: a pilot study in vitro

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 273 - 279

Zusammenfassung

Abstract

Silk fibroin (SF) can be processed into a hydrogel. SF/collagen hydrogel may be a suitable biomaterial for bone tissue engineering.

To investigate in vitro biocompatibility and osteogenic potential of encapsulated rat bone marrow-derived mesenchymal stem cells (rat MSCs) in an injectable Thai SF/collagen hydrogel induced by oleic acid–poloxamer 188 surfactant mixture in an in vitro pilot study.

Rat MSCs were encapsulated in 3 groups of hydrogel scaffolds (SF, SF with 0.05% collagen [SF/0.05C], and SF with 0.1% collagen [SF/0.1C]) and cultured in a growth medium and an osteogenic induction medium. DNA, alkaline phosphatase (ALP) activity, and calcium were assayed at periodically for up to 5 weeks. After 6 weeks of culture the cells were analyzed by scanning electron microscopy and energy dispersive spectroscopy.

Although SF hydrogel with collagen seems to have less efficiency to encapsulate rat MSCs, their plateau phase growth in all hydrogels was comparable. Inability to maintain cell viability as cell populations declined over 1–5 days was observed. Cell numbers then plateaued and were maintained until day 14 of culture. ALP activity and calcium content of rat MSCs in SF/collagen hydrogels were highest at day 21. An enhancing effect of collagen combined with the hydrogel was observed for proliferation and matrix formation; however, benefits of the combination on osteogenic differentiation and biomineralization are as yet unclear.

Rat MSCs in SF and SF/collagen hydrogels showed osteogenic differentiation. Accordingly, these hydrogels may serve as promising scaffolds for bone tissue engineering.

Schlüsselwörter

  • collagen
  • fibroins
  • hydrogels
  • mesenchymal stem cells
  • silk
Uneingeschränkter Zugang

Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

Online veröffentlicht: 24 Oct 2019
Seitenbereich: 281 - 286

Zusammenfassung

Abstract

Vulvar lesion is one of the common gynecologic problems.

To assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).

Pathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.

A total number of 700 patients were included. The proportion of malignant and premalignant lesions in overall vulvar specimens were 16.3% and 8.4%, respectively. Squamous cell carcinoma was the most common malignant vulvar lesion (48.2%), whereas vulvar intraepithelial neoplasia 1 (VIN1) (33.9%) was the most common lesion in the premalignant group. On multivariate analysis, four clinical factors were significantly associated with malignancy risk: increased parity (odds ratio [OR] 1.19, P = 0.010), large tumor size (OR 2.00, P < 0.001), lesion at clitoris (OR 16.67, P = 0.002), and erythematous lesion (OR 2.41, P = 0.026).

The proportion of malignant and premalignant lesions in overall vulvar specimens was 24.7% in KCMH. Increased parity, large tumor size, clitoris-located lesion, and erythematous lesion were associated with increasing malignancy risk.

Schlüsselwörter

  • carcinoma
  • squamous cell
  • vulvar diseases
  • vulvar neoplasms

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