Rivista e Edizione

AHEAD OF PRINT

Volume 61 (2022): Edizione 2 (June 2022)

Volume 61 (2022): Edizione 1 (March 2022)

Volume 60 (2021): Edizione 3 (January 2021)

Volume 60 (2021): Edizione 2 (January 2021)

Volume 60 (2021): Edizione 1 (January 2021)

Volume 59 (2020): Edizione 4 (December 2020)

Volume 59 (2020): Edizione 3 (January 2020)

Volume 59 (2020): Edizione 2 (January 2020)

Volume 59 (2020): Edizione 1 (January 2020)

Volume 58 (2019): Edizione 4 (January 2019)

Volume 58 (2019): Edizione 3 (January 2019)

Volume 58 (2019): Edizione 2 (January 2019)

Volume 58 (2019): Edizione 1 (January 2019)

Volume 57 (2018): Edizione 4 (January 2018)

Volume 57 (2018): Edizione 3 (January 2018)

Volume 57 (2018): Edizione 2 (January 2018)

Volume 57 (2018): Edizione 1 (January 2018)

Volume 56 (2017): Edizione 4 (January 2017)

Volume 56 (2017): Edizione 3 (January 2017)

Volume 56 (2017): Edizione 2 (January 2017)

Volume 56 (2017): Edizione 1 (January 2017)

Dettagli della rivista
Formato
Rivista
eISSN
2545-3149
Pubblicato per la prima volta
01 Mar 1961
Periodo di pubblicazione
4 volte all'anno
Lingue
Inglese, Polacco

Cerca

Volume 60 (2021): Edizione 2 (January 2021)

Dettagli della rivista
Formato
Rivista
eISSN
2545-3149
Pubblicato per la prima volta
01 Mar 1961
Periodo di pubblicazione
4 volte all'anno
Lingue
Inglese, Polacco

Cerca

5 Articoli
Accesso libero

Characteristics And Regulation Of Biofilm Formation In Salmonella

Pubblicato online: 25 Jun 2021
Pagine: 113 - 119

Astratto

Abstract

The ability to from biofilms, which is a common feature in Salmonella serovars, is the main cause of persistent infections and permanent contamination in both clinical and industrial systems. Because the biofilm structures are significantly more resistant to environmental stress conditions than the planktonic forms of bacteria, it is often impossible to remove them through conventional disinfection or sterilization practices. Therefore, it has become necessary to develop effective strategies in combating biofilms, which are defined as the dominant form of microbial life. To achieve this goal, it is necessary to understand the genetic regulatory mechanisms that control the transition from planktonic form to the biofilm form and the related changes in gene expression. In this review, the current state of knowledge regarding gene regulation systems that affect the biofilm formation in Salmonella, has been summarized and discussed.

Parole chiave

  • Typhimurium
  • biofilm
  • genetic regulation
Accesso libero

Coronaviruses – How Protein Interactions Changed Our Perception Of The World

Pubblicato online: 25 Jun 2021
Pagine: 121 - 135

Astratto

Abstract

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the third, following SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and Middle East Respiratory Syndrome-CoV (MERS), zoonotic coronavirus that has crossed the species barrier in XXI century resulting in the development of serious human infection termed COVID-19 (coronavirus disease-19). However, there are still many unanswered questions about its transmissibility and pathogenesis, what impelled us to gather the most recent facts about the nature of coronaviruses. At first we introduced the basic information about coronavirus taxonomy, structure, and replication process to create the basis for more advanced consideration. We also put across the molecular basis of the strategy used by coronaviruses to cross the species barrier. In the following part of this review we focused on the interactions between the virus and the receptor on the host cell, as this stage is the critical process determining the species and tissue tropism, as well as clinical course of infection. The special attention was paid to the cellular receptors interaction with S protein of different CoVs (dipeptidyl peptidase IV and angiotensin-converting enzyme 2) as well as the cellular proteases involved in proteolysis of this protein. These factors determine the virus entry and replication, thus even the fine quantitative or qualitative difference in their expression may be crucial for outcome of infection. We also considered the host immune response and viral evasion mechanisms which would be helpful to understand COVID-19 pathogenesis. We wish the information provided by this review may be helpful to understand virus biology and to develop efficient therapeutic and preventive strategies.

Parole chiave

  • ACE2
  • COVID-19
  • DPP4
  • coronavirus

Słowa kluczowe

  • ACE2
  • COVID-19
  • DPP4
  • koronawirus
Accesso libero

Protein Glycosylation In Bacterial Cells And Its Potential Applications

Pubblicato online: 25 Jun 2021
Pagine: 137 - 149

Astratto

Abstract

Bacterial glycoconjugates are widespread and have diverse biological functions. Multiple bacterial glycoproteins are involved in adhesion, invasion or evasion of host defense mechanisms. A range of glycosylation pathways has recently been an object of intense research. Their activity is based on the glycosyltransferases – enzymes that transfer sugar moieties directly to the acceptor protein (sequential glycosylation) or to a lipid carrier from which the glycan is transferred by an oligosaccharyltransferase onto the target protein (en-bloc glycosylation). Successful implementation of complete glycosylation systems in Escherichia coli cells resulted in rapid development of bacterial glycoengineering. Oligosaccharyltransferases are characterized by a broad substrate specificity which may be exploited to produce glycoconjugate vaccines.

Parole chiave

  • glycoproteins
  • glycosylation
  • glycoengineering

Słowa kluczowe

  • glikoproteiny
  • glikoinżynieria
  • glikozylacja
Accesso libero

The Influence Of The Reproductive System Microbiota On Female And Male Fertility. The Role Of Lactobacillus Bacteria

Pubblicato online: 25 Jun 2021
Pagine: 151 - 159

Astratto

Abstract

It is well known, that vaginal microbiota is dominated by Lactobacillus genus. These bacteria protect a vaginal microenvironment against the invading pathogens. The presence of Lactobacillus communities was already confirmed in an upper female reproductive system, as well as in the male reproductive system and semen. In this paper we present the current state of knowledge about the influence of the Lactobacillus species on female and male fertility. We also discuss the possible role of the reproductive system microbiota in an idiopathic infertility, and the association between Lactobacillus species and effectiveness of assisted reproductive techniques. Further research on the relationship between the reproductive system microbiota and human fertility is needed.

Parole chiave

  • idiopatic infertility
  • fertility
  • assisted reproductive techniques

Słowa kluczowe

  • niepłodność idiopatyczna
  • płodność
  • techniki wspomaganego rozrodu
Accesso libero

Phytotherapy In The Prevention And Support Of Treatment Of Helicobacter Pylori Infections

Pubblicato online: 25 Jun 2021
Pagine: 161 - 172

Astratto

Abstract

Helicobacter pylori is a Gram-negative, rod-shaped bacterium with an ability to colonise the gastric pylorus. It is estimated that more than half of the human population may be carriers of this pathogen. Unfortunately, the collected data concerning H. pylori infections is inaccurate as the symptoms occur only in 20% of people infected. The presence of the bacteria may lead to inflammation, stomach ulcers, or even cancer. In the cases of confirmed infection, the treatment usually involves a so called “triple therapy” with a proton-pump inhibitor and antibiotics. However, a decrease in the effectiveness of this therapy is observed as a result of increasing antibiotic resistance in bacteria. New solutions are being researched that could both help in the treatment of H. pylori infections and prevent the spread of the pathogen. Numerous scientific studies confirm that the use of plant-based products can be a good addition to the treatment of various infections. Phytotherapy is a science-based medical practice that uses the knowledge about active compounds naturally occurring in plants, in order to improve overall health. From existing research, it is known that the consumption of certain plant-derived products, for example olive oil and green tea, can lead to H. pylori eradication. On the other hand, licorice can be used to support the classic treatment method by increasing the eradication rate of the pathogen. Plants with anti-H. pylori properties include: cinnamon, cranberry, oregano, aloe vera and many others. The aim of this work is to review literature that is focused on a potential use of phytotherapy to support the treatment, combat, or prevent infections caused by H. pylori.

Parole chiave

  • phytotherapy
  • plant active substances
  • infections

Słowa kluczowe

  • fitoterapia
  • roślinne substancje czynne
  • infekcje
5 Articoli
Accesso libero

Characteristics And Regulation Of Biofilm Formation In Salmonella

Pubblicato online: 25 Jun 2021
Pagine: 113 - 119

Astratto

Abstract

The ability to from biofilms, which is a common feature in Salmonella serovars, is the main cause of persistent infections and permanent contamination in both clinical and industrial systems. Because the biofilm structures are significantly more resistant to environmental stress conditions than the planktonic forms of bacteria, it is often impossible to remove them through conventional disinfection or sterilization practices. Therefore, it has become necessary to develop effective strategies in combating biofilms, which are defined as the dominant form of microbial life. To achieve this goal, it is necessary to understand the genetic regulatory mechanisms that control the transition from planktonic form to the biofilm form and the related changes in gene expression. In this review, the current state of knowledge regarding gene regulation systems that affect the biofilm formation in Salmonella, has been summarized and discussed.

Parole chiave

  • Typhimurium
  • biofilm
  • genetic regulation
Accesso libero

Coronaviruses – How Protein Interactions Changed Our Perception Of The World

Pubblicato online: 25 Jun 2021
Pagine: 121 - 135

Astratto

Abstract

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the third, following SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and Middle East Respiratory Syndrome-CoV (MERS), zoonotic coronavirus that has crossed the species barrier in XXI century resulting in the development of serious human infection termed COVID-19 (coronavirus disease-19). However, there are still many unanswered questions about its transmissibility and pathogenesis, what impelled us to gather the most recent facts about the nature of coronaviruses. At first we introduced the basic information about coronavirus taxonomy, structure, and replication process to create the basis for more advanced consideration. We also put across the molecular basis of the strategy used by coronaviruses to cross the species barrier. In the following part of this review we focused on the interactions between the virus and the receptor on the host cell, as this stage is the critical process determining the species and tissue tropism, as well as clinical course of infection. The special attention was paid to the cellular receptors interaction with S protein of different CoVs (dipeptidyl peptidase IV and angiotensin-converting enzyme 2) as well as the cellular proteases involved in proteolysis of this protein. These factors determine the virus entry and replication, thus even the fine quantitative or qualitative difference in their expression may be crucial for outcome of infection. We also considered the host immune response and viral evasion mechanisms which would be helpful to understand COVID-19 pathogenesis. We wish the information provided by this review may be helpful to understand virus biology and to develop efficient therapeutic and preventive strategies.

Parole chiave

  • ACE2
  • COVID-19
  • DPP4
  • coronavirus

Słowa kluczowe

  • ACE2
  • COVID-19
  • DPP4
  • koronawirus
Accesso libero

Protein Glycosylation In Bacterial Cells And Its Potential Applications

Pubblicato online: 25 Jun 2021
Pagine: 137 - 149

Astratto

Abstract

Bacterial glycoconjugates are widespread and have diverse biological functions. Multiple bacterial glycoproteins are involved in adhesion, invasion or evasion of host defense mechanisms. A range of glycosylation pathways has recently been an object of intense research. Their activity is based on the glycosyltransferases – enzymes that transfer sugar moieties directly to the acceptor protein (sequential glycosylation) or to a lipid carrier from which the glycan is transferred by an oligosaccharyltransferase onto the target protein (en-bloc glycosylation). Successful implementation of complete glycosylation systems in Escherichia coli cells resulted in rapid development of bacterial glycoengineering. Oligosaccharyltransferases are characterized by a broad substrate specificity which may be exploited to produce glycoconjugate vaccines.

Parole chiave

  • glycoproteins
  • glycosylation
  • glycoengineering

Słowa kluczowe

  • glikoproteiny
  • glikoinżynieria
  • glikozylacja
Accesso libero

The Influence Of The Reproductive System Microbiota On Female And Male Fertility. The Role Of Lactobacillus Bacteria

Pubblicato online: 25 Jun 2021
Pagine: 151 - 159

Astratto

Abstract

It is well known, that vaginal microbiota is dominated by Lactobacillus genus. These bacteria protect a vaginal microenvironment against the invading pathogens. The presence of Lactobacillus communities was already confirmed in an upper female reproductive system, as well as in the male reproductive system and semen. In this paper we present the current state of knowledge about the influence of the Lactobacillus species on female and male fertility. We also discuss the possible role of the reproductive system microbiota in an idiopathic infertility, and the association between Lactobacillus species and effectiveness of assisted reproductive techniques. Further research on the relationship between the reproductive system microbiota and human fertility is needed.

Parole chiave

  • idiopatic infertility
  • fertility
  • assisted reproductive techniques

Słowa kluczowe

  • niepłodność idiopatyczna
  • płodność
  • techniki wspomaganego rozrodu
Accesso libero

Phytotherapy In The Prevention And Support Of Treatment Of Helicobacter Pylori Infections

Pubblicato online: 25 Jun 2021
Pagine: 161 - 172

Astratto

Abstract

Helicobacter pylori is a Gram-negative, rod-shaped bacterium with an ability to colonise the gastric pylorus. It is estimated that more than half of the human population may be carriers of this pathogen. Unfortunately, the collected data concerning H. pylori infections is inaccurate as the symptoms occur only in 20% of people infected. The presence of the bacteria may lead to inflammation, stomach ulcers, or even cancer. In the cases of confirmed infection, the treatment usually involves a so called “triple therapy” with a proton-pump inhibitor and antibiotics. However, a decrease in the effectiveness of this therapy is observed as a result of increasing antibiotic resistance in bacteria. New solutions are being researched that could both help in the treatment of H. pylori infections and prevent the spread of the pathogen. Numerous scientific studies confirm that the use of plant-based products can be a good addition to the treatment of various infections. Phytotherapy is a science-based medical practice that uses the knowledge about active compounds naturally occurring in plants, in order to improve overall health. From existing research, it is known that the consumption of certain plant-derived products, for example olive oil and green tea, can lead to H. pylori eradication. On the other hand, licorice can be used to support the classic treatment method by increasing the eradication rate of the pathogen. Plants with anti-H. pylori properties include: cinnamon, cranberry, oregano, aloe vera and many others. The aim of this work is to review literature that is focused on a potential use of phytotherapy to support the treatment, combat, or prevent infections caused by H. pylori.

Parole chiave

  • phytotherapy
  • plant active substances
  • infections

Słowa kluczowe

  • fitoterapia
  • roślinne substancje czynne
  • infekcje

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