Edizioni

Rivista e Edizione

AHEAD OF PRINT

Volume 61 (2022): Edizione 4 (December 2022)

Volume 61 (2022): Edizione 3 (September 2022)

Volume 61 (2022): Edizione 2 (June 2022)

Volume 61 (2022): Edizione 1 (March 2022)

Volume 60 (2021): Edizione 4 (December 2021)

Volume 60 (2021): Edizione 3 (January 2021)

Volume 60 (2021): Edizione 2 (January 2021)

Volume 60 (2021): Edizione 1 (January 2021)

Volume 59 (2020): Edizione 4 (December 2020)

Volume 59 (2020): Edizione 3 (January 2020)

Volume 59 (2020): Edizione 2 (January 2020)

Volume 59 (2020): Edizione 1 (January 2020)

Volume 58 (2019): Edizione 4 (January 2019)

Volume 58 (2019): Edizione 3 (January 2019)

Volume 58 (2019): Edizione 2 (January 2019)

Volume 58 (2019): Edizione 1 (January 2019)

Volume 57 (2018): Edizione 4 (January 2018)

Volume 57 (2018): Edizione 3 (January 2018)

Volume 57 (2018): Edizione 2 (January 2018)

Volume 57 (2018): Edizione 1 (January 2018)

Volume 56 (2017): Edizione 4 (January 2017)

Volume 56 (2017): Edizione 3 (January 2017)

Volume 56 (2017): Edizione 2 (January 2017)

Volume 56 (2017): Edizione 1 (January 2017)

Dettagli della rivista
Formato
Rivista
eISSN
2545-3149
Pubblicato per la prima volta
01 Mar 1961
Periodo di pubblicazione
4 volte all'anno
Lingue
Inglese, Polacco

Cerca

AHEAD OF PRINT

Dettagli della rivista
Formato
Rivista
eISSN
2545-3149
Pubblicato per la prima volta
01 Mar 1961
Periodo di pubblicazione
4 volte all'anno
Lingue
Inglese, Polacco

Cerca

8 Articoli
Accesso libero

Selected Bacterial Zoonoses Transmitted by Raw Milk

Pubblicato online: 09 Jun 2022
Pagine: -

Astratto

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Parole chiave

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Accesso libero

Endophytic Fungi as Potential Producers of Anticancer Compounds

Pubblicato online: 09 Jun 2022
Pagine: -

Astratto

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Parole chiave

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Accesso libero

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Pubblicato online: 24 Jul 2022
Pagine: -

Astratto

Abstract

Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.

Parole chiave

  • Antimicrobial resistance
  • MDR
  • Multidrug efflux pumps
  • Biofilm
  • Efflux Pump Inhibtor (EPI)
Accesso libero

RETRACTION OF: Sebastian Gnat, Aneta Nowakiewicz, Przemysław Zięba: Taxonomy of dermatophytes – the classification systems may change but the identification problems remain the same.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz: Zastosowanie techniki MALDI-TOF MS do identyfikacji dermatofitów.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Dominik Łagowski, Sebastian Gnat, Aneta Nowakiewicz: Mechanizmy powstawania oporności dermatofitów na substancje przeciwgrzybicze.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Mariusz Dyląg: Molekularne metody diagnostyki dermatomykoz – przegląd dostępnych technik oraz ocena ich zalet i wad w implementacji do rutynowego stosowania.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Aneta Nowakiewicz: Ludzki mykobiom w stanach normobiozy i dysbiozy– charakterystyka i metody analizy.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

8 Articoli
Accesso libero

Selected Bacterial Zoonoses Transmitted by Raw Milk

Pubblicato online: 09 Jun 2022
Pagine: -

Astratto

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Parole chiave

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Accesso libero

Endophytic Fungi as Potential Producers of Anticancer Compounds

Pubblicato online: 09 Jun 2022
Pagine: -

Astratto

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Parole chiave

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Accesso libero

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Pubblicato online: 24 Jul 2022
Pagine: -

Astratto

Abstract

Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.

Parole chiave

  • Antimicrobial resistance
  • MDR
  • Multidrug efflux pumps
  • Biofilm
  • Efflux Pump Inhibtor (EPI)
Accesso libero

RETRACTION OF: Sebastian Gnat, Aneta Nowakiewicz, Przemysław Zięba: Taxonomy of dermatophytes – the classification systems may change but the identification problems remain the same.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz: Zastosowanie techniki MALDI-TOF MS do identyfikacji dermatofitów.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Dominik Łagowski, Sebastian Gnat, Aneta Nowakiewicz: Mechanizmy powstawania oporności dermatofitów na substancje przeciwgrzybicze.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Mariusz Dyląg: Molekularne metody diagnostyki dermatomykoz – przegląd dostępnych technik oraz ocena ich zalet i wad w implementacji do rutynowego stosowania.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Accesso libero

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Aneta Nowakiewicz: Ludzki mykobiom w stanach normobiozy i dysbiozy– charakterystyka i metody analizy.

Pubblicato online: 30 Oct 2022
Pagine: -

Astratto

Pianifica la tua conferenza remota con Sciendo