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Volumen 59 (2020): Heft 2 (January 2020)

Volumen 59 (2020): Heft 1 (January 2020)

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Volumen 58 (2019): Heft 3 (January 2019)

Volumen 58 (2019): Heft 2 (January 2019)

Volumen 58 (2019): Heft 1 (January 2019)

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Volumen 57 (2018): Heft 3 (January 2018)

Volumen 57 (2018): Heft 2 (January 2018)

Volumen 57 (2018): Heft 1 (January 2018)

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Zeitschriftendaten
Format
Zeitschrift
eISSN
2545-3149
Erstveröffentlichung
01 Mar 1961
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch, Polieren

Suche

AHEAD OF PRINT

Zeitschriftendaten
Format
Zeitschrift
eISSN
2545-3149
Erstveröffentlichung
01 Mar 1961
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch, Polieren

Suche

3 Artikel
Uneingeschränkter Zugang

GRZYBY ENDOFITYCZNE W ROLI POTENCJALNYCH PRODUCENTÓW ZWIĄZKÓW PRZECIWNOWOTWOROWYCH

Online veröffentlicht: 09 Jun 2022
Seitenbereich: -

Zusammenfassung

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Schlüsselwörter

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Uneingeschränkter Zugang

WYBRANE ZOONOZY BAKTERYJNE PRZENOSZONE PRZEZ MLEKO SUROWE

Online veröffentlicht: 09 Jun 2022
Seitenbereich: -

Zusammenfassung

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Schlüsselwörter

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Uneingeschränkter Zugang

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Online veröffentlicht: 24 Jul 2022
Seitenbereich: -

Zusammenfassung

Abstract

Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.

Schlüsselwörter

  • Antimicrobial resistance
  • MDR
  • Multidrug efflux pumps
  • Biofilm
  • Efflux Pump Inhibtor (EPI)
3 Artikel
Uneingeschränkter Zugang

GRZYBY ENDOFITYCZNE W ROLI POTENCJALNYCH PRODUCENTÓW ZWIĄZKÓW PRZECIWNOWOTWOROWYCH

Online veröffentlicht: 09 Jun 2022
Seitenbereich: -

Zusammenfassung

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Schlüsselwörter

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Uneingeschränkter Zugang

WYBRANE ZOONOZY BAKTERYJNE PRZENOSZONE PRZEZ MLEKO SUROWE

Online veröffentlicht: 09 Jun 2022
Seitenbereich: -

Zusammenfassung

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Schlüsselwörter

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Uneingeschränkter Zugang

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Online veröffentlicht: 24 Jul 2022
Seitenbereich: -

Zusammenfassung

Abstract

Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.

Schlüsselwörter

  • Antimicrobial resistance
  • MDR
  • Multidrug efflux pumps
  • Biofilm
  • Efflux Pump Inhibtor (EPI)

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