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Volume 61 (2022): Edition 3 (September 2022)

Volume 61 (2022): Edition 2 (June 2022)

Volume 61 (2022): Edition 1 (March 2022)

Volume 60 (2021): Edition 4 (December 2021)

Volume 60 (2021): Edition 3 (January 2021)

Volume 60 (2021): Edition 2 (January 2021)

Volume 60 (2021): Edition 1 (January 2021)

Volume 59 (2020): Edition 4 (December 2020)

Volume 59 (2020): Edition 3 (January 2020)

Volume 59 (2020): Edition 2 (January 2020)

Volume 59 (2020): Edition 1 (January 2020)

Volume 58 (2019): Edition 4 (January 2019)

Volume 58 (2019): Edition 3 (January 2019)

Volume 58 (2019): Edition 2 (January 2019)

Volume 58 (2019): Edition 1 (January 2019)

Volume 57 (2018): Edition 4 (January 2018)

Volume 57 (2018): Edition 3 (January 2018)

Volume 57 (2018): Edition 2 (January 2018)

Volume 57 (2018): Edition 1 (January 2018)

Volume 56 (2017): Edition 4 (January 2017)

Volume 56 (2017): Edition 3 (January 2017)

Volume 56 (2017): Edition 2 (January 2017)

Volume 56 (2017): Edition 1 (January 2017)

Détails du magazine
Format
Magazine
eISSN
2545-3149
Première publication
01 Mar 1961
Période de publication
4 fois par an
Langues
Anglais, Polonais

Chercher

AHEAD OF PRINT

Détails du magazine
Format
Magazine
eISSN
2545-3149
Première publication
01 Mar 1961
Période de publication
4 fois par an
Langues
Anglais, Polonais

Chercher

8 Articles
Accès libre

Selected Bacterial Zoonoses Transmitted by Raw Milk

Publié en ligne: 09 Jun 2022
Pages: -

Résumé

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Mots clés

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Accès libre

Endophytic Fungi as Potential Producers of Anticancer Compounds

Publié en ligne: 09 Jun 2022
Pages: -

Résumé

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Mots clés

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Accès libre

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Publié en ligne: 24 Jul 2022
Pages: -

Résumé

Abstract

Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.

Mots clés

  • Antimicrobial resistance
  • MDR
  • Multidrug efflux pumps
  • Biofilm
  • Efflux Pump Inhibtor (EPI)
Accès libre

RETRACTION OF: Sebastian Gnat, Aneta Nowakiewicz, Przemysław Zięba: Taxonomy of dermatophytes – the classification systems may change but the identification problems remain the same.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz: Zastosowanie techniki MALDI-TOF MS do identyfikacji dermatofitów.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Dominik Łagowski, Sebastian Gnat, Aneta Nowakiewicz: Mechanizmy powstawania oporności dermatofitów na substancje przeciwgrzybicze.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Mariusz Dyląg: Molekularne metody diagnostyki dermatomykoz – przegląd dostępnych technik oraz ocena ich zalet i wad w implementacji do rutynowego stosowania.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Aneta Nowakiewicz: Ludzki mykobiom w stanach normobiozy i dysbiozy– charakterystyka i metody analizy.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

8 Articles
Accès libre

Selected Bacterial Zoonoses Transmitted by Raw Milk

Publié en ligne: 09 Jun 2022
Pages: -

Résumé

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Mots clés

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Accès libre

Endophytic Fungi as Potential Producers of Anticancer Compounds

Publié en ligne: 09 Jun 2022
Pages: -

Résumé

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Mots clés

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Accès libre

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Publié en ligne: 24 Jul 2022
Pages: -

Résumé

Abstract

Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.

Mots clés

  • Antimicrobial resistance
  • MDR
  • Multidrug efflux pumps
  • Biofilm
  • Efflux Pump Inhibtor (EPI)
Accès libre

RETRACTION OF: Sebastian Gnat, Aneta Nowakiewicz, Przemysław Zięba: Taxonomy of dermatophytes – the classification systems may change but the identification problems remain the same.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz: Zastosowanie techniki MALDI-TOF MS do identyfikacji dermatofitów.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Dominik Łagowski, Sebastian Gnat, Aneta Nowakiewicz: Mechanizmy powstawania oporności dermatofitów na substancje przeciwgrzybicze.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Mariusz Dyląg: Molekularne metody diagnostyki dermatomykoz – przegląd dostępnych technik oraz ocena ich zalet i wad w implementacji do rutynowego stosowania.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

Accès libre

RETRACTION OF: Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Aneta Nowakiewicz: Ludzki mykobiom w stanach normobiozy i dysbiozy– charakterystyka i metody analizy.

Publié en ligne: 30 Oct 2022
Pages: -

Résumé

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