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Journal Details
Format
Journal
eISSN
1898-0309
First Published
30 Dec 2008
Publication timeframe
4 times per year
Languages
English

Search

Volume 15 (2009): Issue 1 (March 2009)

Journal Details
Format
Journal
eISSN
1898-0309
First Published
30 Dec 2008
Publication timeframe
4 times per year
Languages
English

Search

5 Articles
Open Access

EFOMP project on the role of biomedical physics in the education of healthcare professionals

Published Online: 22 Sep 2010
Page range: 1 - 9

Abstract

EFOMP project on the role of biomedical physics in the education of healthcare professionals

The policy statements describing the role of the medical physicist (and engineer) published by organizations representing medical physics (and engineering) in Europe include the responsibility of providing a contribution to the education of healthcare professionals (physicians and paramedical professions). As a consequence, medical physicists and engineers provide educational services in most Faculties of Medicine / Health Science in Europe. In 2005, the EFOMP council took the decision to set up a Special Interest Group to develop the role of the medical physics educator in such faculties and to work with other healthcare professional groups to produce updated European curricula for them. The effort of the group would provide a base for the progress of the role, its relevance to contemporary healthcare professional education and provide input for future EFOMP policy documents regarding this important aspect of the role of the medical physicist. The present communication will present the group, summarise its latest research and indicate future research directions.

Keywords

  • biomedical physics education
  • medical education
  • academic role development
  • curriculum development
Open Access

Analysis of the calibration results of ionization chambers for orthovoltage and brachytherapy

Published Online: 22 Sep 2010
Page range: 11 - 24

Abstract

Analysis of the calibration results of ionization chambers for orthovoltage and brachytherapy

An analysis of the exposure calibration coefficients for ionization chambers used for dose determination in orthovoltage radiotherapy and in brachytherapy in the Polish SSDL was performed. The coefficients were determined by calibrating the chambers in the X-ray beam of 235 kV or 290 kV and HVL of 2.5 mmCu or 4 mmCu respectively, and also in the Co-60 gamma beam. Calibration procedures followed IAEA recommendations in Report No. TECDOC 1274 and Technical Reports Series No. 277. The characteristics of the energy dependence of various types of chambers used in orthovoltage radiotherapy and in brachytherapy are presented. On the basis of the summarized data and on the energy dependence curves it was possible to conclude that: 1) in he case of calibration of the chambers for orthovoltage radiotherapy the energy dependence has to be established for the full range beam qualities; 2) in the case of calibration, of the investigated chambers, for brahytherapy with Cs-137 and Ir-192 sources, establishing of the exposure calibration factor for Co-60 is sufficient.

Keywords

  • radiotherapy
  • brachytherapy
  • SSDL
  • calibration coefficients
  • ionization chambers
Open Access

The design of an insulin pump - preliminary requirements (a technical note)

Published Online: 22 Sep 2010
Page range: 25 - 32

Abstract

The design of an insulin pump - preliminary requirements (a technical note)

The material presented in this paper is an attempt to lay down requirements for the planned design of an insulin pump. An insulin pump is a device for continuous dosage of insulin at a selected rate, which facilitates treatment and improves the lives of diabetic patients. This paper is a compilation of medical requirements and user suggestions of presently offered insulin pumps.

It seems important to establish proper requirements for a device before starting developing any design for an insulin pump.

Keywords

  • Insulin pump
  • insulin administration
  • diabetes
Open Access

External beam radiotherapy for palliation of painful bone metastases: pooled data bioeffect dose response analysis of dose fractionation

Published Online: 22 Sep 2010
Page range: 33 - 45

Abstract

External beam radiotherapy for palliation of painful bone metastases: pooled data bioeffect dose response analysis of dose fractionation

Bone metastases develop in up to 70% of newly diagnosed cancer patients and result in immobility, anxiety, and depression, severely diminishing the patients quality of life. Radiotherapy is a frequently used modality for bone metastasis and has been shown to be effective in reducing metastatic bone pain and in some instances, causing tumor shrinkage or growth inhibition. There is controversy surrounding the optimal fractionation schedule and total dose of external beam radiotherapy, despite many randomized trials and overviews addressing the issue. This study was undertaken to apply BED to clinical fractionation data of radiotherapeutic management of bone metastases in order to arrive at optimum BED values for acceptable level of response rate.

A computerised literature search was conducted to identify all prospective clinical studies that addressed the issue of fractionation for the treatment of bone metastasis. The results of these studies were pooled together to form the database for the analysis. A total of 4111 number of patients received radiation dose ranging from 4 to 40.5 Gy in 1 to 15 fractions with dose per fraction ranging from 2 to 10 Gy. Single fraction treatments were delivered in 2013 patients and the dose varied from 4 to 10 Gy. Multifraction treatments were delivered in 2098 patients and the dose varied from 15 to 40.5 Gy. The biological effective dose (BED) was evaluated for each fractionation schedule using the linear quadratic model and an α/β value of 10 Gy. Response rate increased significantly beyond a BED value of 14.4 Gy (p < 0.01). Based on our analysis and indications from the literature about higher retreatment and fracture rate of single fraction treatments, minimum BED value of 14.4 Gy is recommended.

Keywords

  • palliative radiotherapy
  • painful bone metastases
Open Access

Spin traps in the detection of free radicals in the blood of patients with ischemia

Published Online: 22 Sep 2010
Page range: 47 - 54

Abstract

Spin traps in the detection of free radicals in the blood of patients with ischemia

Electron Paramagnetic Resonance and a nitrosobenzene spin trap were used to investigate free radicals in the human blood after angioplasty treatment. The nitrosobenzene anion radical was determined using EPR measurements and quantum-mechanical calculations. Differences were observed in the concentration of free radicals before and after angioplasty treatment. These results were compared with myocardium damage parameters (CPK, MB and TnT).

Keywords

  • Electron Paramagnetic Resonance
  • nitrosobenzene spin trap
  • angioplasty treatment
  • free radicals
5 Articles
Open Access

EFOMP project on the role of biomedical physics in the education of healthcare professionals

Published Online: 22 Sep 2010
Page range: 1 - 9

Abstract

EFOMP project on the role of biomedical physics in the education of healthcare professionals

The policy statements describing the role of the medical physicist (and engineer) published by organizations representing medical physics (and engineering) in Europe include the responsibility of providing a contribution to the education of healthcare professionals (physicians and paramedical professions). As a consequence, medical physicists and engineers provide educational services in most Faculties of Medicine / Health Science in Europe. In 2005, the EFOMP council took the decision to set up a Special Interest Group to develop the role of the medical physics educator in such faculties and to work with other healthcare professional groups to produce updated European curricula for them. The effort of the group would provide a base for the progress of the role, its relevance to contemporary healthcare professional education and provide input for future EFOMP policy documents regarding this important aspect of the role of the medical physicist. The present communication will present the group, summarise its latest research and indicate future research directions.

Keywords

  • biomedical physics education
  • medical education
  • academic role development
  • curriculum development
Open Access

Analysis of the calibration results of ionization chambers for orthovoltage and brachytherapy

Published Online: 22 Sep 2010
Page range: 11 - 24

Abstract

Analysis of the calibration results of ionization chambers for orthovoltage and brachytherapy

An analysis of the exposure calibration coefficients for ionization chambers used for dose determination in orthovoltage radiotherapy and in brachytherapy in the Polish SSDL was performed. The coefficients were determined by calibrating the chambers in the X-ray beam of 235 kV or 290 kV and HVL of 2.5 mmCu or 4 mmCu respectively, and also in the Co-60 gamma beam. Calibration procedures followed IAEA recommendations in Report No. TECDOC 1274 and Technical Reports Series No. 277. The characteristics of the energy dependence of various types of chambers used in orthovoltage radiotherapy and in brachytherapy are presented. On the basis of the summarized data and on the energy dependence curves it was possible to conclude that: 1) in he case of calibration of the chambers for orthovoltage radiotherapy the energy dependence has to be established for the full range beam qualities; 2) in the case of calibration, of the investigated chambers, for brahytherapy with Cs-137 and Ir-192 sources, establishing of the exposure calibration factor for Co-60 is sufficient.

Keywords

  • radiotherapy
  • brachytherapy
  • SSDL
  • calibration coefficients
  • ionization chambers
Open Access

The design of an insulin pump - preliminary requirements (a technical note)

Published Online: 22 Sep 2010
Page range: 25 - 32

Abstract

The design of an insulin pump - preliminary requirements (a technical note)

The material presented in this paper is an attempt to lay down requirements for the planned design of an insulin pump. An insulin pump is a device for continuous dosage of insulin at a selected rate, which facilitates treatment and improves the lives of diabetic patients. This paper is a compilation of medical requirements and user suggestions of presently offered insulin pumps.

It seems important to establish proper requirements for a device before starting developing any design for an insulin pump.

Keywords

  • Insulin pump
  • insulin administration
  • diabetes
Open Access

External beam radiotherapy for palliation of painful bone metastases: pooled data bioeffect dose response analysis of dose fractionation

Published Online: 22 Sep 2010
Page range: 33 - 45

Abstract

External beam radiotherapy for palliation of painful bone metastases: pooled data bioeffect dose response analysis of dose fractionation

Bone metastases develop in up to 70% of newly diagnosed cancer patients and result in immobility, anxiety, and depression, severely diminishing the patients quality of life. Radiotherapy is a frequently used modality for bone metastasis and has been shown to be effective in reducing metastatic bone pain and in some instances, causing tumor shrinkage or growth inhibition. There is controversy surrounding the optimal fractionation schedule and total dose of external beam radiotherapy, despite many randomized trials and overviews addressing the issue. This study was undertaken to apply BED to clinical fractionation data of radiotherapeutic management of bone metastases in order to arrive at optimum BED values for acceptable level of response rate.

A computerised literature search was conducted to identify all prospective clinical studies that addressed the issue of fractionation for the treatment of bone metastasis. The results of these studies were pooled together to form the database for the analysis. A total of 4111 number of patients received radiation dose ranging from 4 to 40.5 Gy in 1 to 15 fractions with dose per fraction ranging from 2 to 10 Gy. Single fraction treatments were delivered in 2013 patients and the dose varied from 4 to 10 Gy. Multifraction treatments were delivered in 2098 patients and the dose varied from 15 to 40.5 Gy. The biological effective dose (BED) was evaluated for each fractionation schedule using the linear quadratic model and an α/β value of 10 Gy. Response rate increased significantly beyond a BED value of 14.4 Gy (p < 0.01). Based on our analysis and indications from the literature about higher retreatment and fracture rate of single fraction treatments, minimum BED value of 14.4 Gy is recommended.

Keywords

  • palliative radiotherapy
  • painful bone metastases
Open Access

Spin traps in the detection of free radicals in the blood of patients with ischemia

Published Online: 22 Sep 2010
Page range: 47 - 54

Abstract

Spin traps in the detection of free radicals in the blood of patients with ischemia

Electron Paramagnetic Resonance and a nitrosobenzene spin trap were used to investigate free radicals in the human blood after angioplasty treatment. The nitrosobenzene anion radical was determined using EPR measurements and quantum-mechanical calculations. Differences were observed in the concentration of free radicals before and after angioplasty treatment. These results were compared with myocardium damage parameters (CPK, MB and TnT).

Keywords

  • Electron Paramagnetic Resonance
  • nitrosobenzene spin trap
  • angioplasty treatment
  • free radicals

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