Magazine et Edition

AHEAD OF PRINT

Volume 61 (2022): Edition 4 (December 2022)

Volume 61 (2022): Edition 3 (September 2022)

Volume 61 (2022): Edition 2 (June 2022)

Volume 61 (2022): Edition 1 (March 2022)

Volume 60 (2021): Edition 4 (December 2021)

Volume 60 (2021): Edition 3 (January 2021)

Volume 60 (2021): Edition 2 (January 2021)

Volume 60 (2021): Edition 1 (January 2021)

Volume 59 (2020): Edition 4 (December 2020)

Volume 59 (2020): Edition 3 (January 2020)

Volume 59 (2020): Edition 2 (January 2020)

Volume 59 (2020): Edition 1 (January 2020)

Volume 58 (2019): Edition 4 (January 2019)

Volume 58 (2019): Edition 3 (January 2019)

Volume 58 (2019): Edition 2 (January 2019)

Volume 58 (2019): Edition 1 (January 2019)

Volume 57 (2018): Edition 4 (January 2018)

Volume 57 (2018): Edition 3 (January 2018)

Volume 57 (2018): Edition 2 (January 2018)

Volume 57 (2018): Edition 1 (January 2018)

Volume 56 (2017): Edition 4 (January 2017)

Volume 56 (2017): Edition 3 (January 2017)

Volume 56 (2017): Edition 2 (January 2017)

Volume 56 (2017): Edition 1 (January 2017)

Détails du magazine
Format
Magazine
eISSN
2545-3149
Première publication
01 Mar 1961
Période de publication
4 fois par an
Langues
Anglais, Polonais

Chercher

Volume 61 (2022): Edition 2 (June 2022)

Détails du magazine
Format
Magazine
eISSN
2545-3149
Première publication
01 Mar 1961
Période de publication
4 fois par an
Langues
Anglais, Polonais

Chercher

3 Articles
Accès libre

Endophytic Fungi as Potential Producers of Anticancer Compounds

Publié en ligne: 09 Jun 2022
Pages: 63 - 72

Résumé

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Mots clés

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Accès libre

Selected Bacterial Zoonoses Transmitted by Raw Milk

Publié en ligne: 09 Jun 2022
Pages: 73 - 80

Résumé

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Mots clés

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Accès libre

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in Escherichia coli

Publié en ligne: 25 Jun 2022
Pages: 81 - 93

Résumé

Abstract

Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different macromolecules in vivo and result in the inactivation of these molecules. But the mechanism to counteract the effect of nitrosative stress is poorly understood. Escherichia coli is one of the best understood and well-studied microorganism. Although several studies have been reported on Escherichia coli to characterize the effect of various stress response but fewer works are there to see the effect of nitrosative stress. Escherichia coli encounter numerous stresses during its growth, survival, and infection. They respond to various stress conditions by activating common regulator proteins and thiols. These stress conditions result in the accumulation of these regulator proteins and thiols that allow cells to adjust to specific stress situations, conferring stress tolerance and survival. In this review, different enzymatic and non-enzymatic mechanisms to counteract the effect of nitrosative stress in Escherichia coli have been discussed and a hypothesis for the working mechanism of hybrid cluster protein that helps to combat nitrosative stress has been proposed. Here, we have tried to give a clear scenario about the mode of action of stress-responsive elements present in Escherichia coli.

Mots clés

  • nitrosative stress
  • protein tyrosine nitration
  • reactive nitrogen species
  • stress response
3 Articles
Accès libre

Endophytic Fungi as Potential Producers of Anticancer Compounds

Publié en ligne: 09 Jun 2022
Pages: 63 - 72

Résumé

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Mots clés

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Accès libre

Selected Bacterial Zoonoses Transmitted by Raw Milk

Publié en ligne: 09 Jun 2022
Pages: 73 - 80

Résumé

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Mots clés

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Accès libre

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in Escherichia coli

Publié en ligne: 25 Jun 2022
Pages: 81 - 93

Résumé

Abstract

Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different macromolecules in vivo and result in the inactivation of these molecules. But the mechanism to counteract the effect of nitrosative stress is poorly understood. Escherichia coli is one of the best understood and well-studied microorganism. Although several studies have been reported on Escherichia coli to characterize the effect of various stress response but fewer works are there to see the effect of nitrosative stress. Escherichia coli encounter numerous stresses during its growth, survival, and infection. They respond to various stress conditions by activating common regulator proteins and thiols. These stress conditions result in the accumulation of these regulator proteins and thiols that allow cells to adjust to specific stress situations, conferring stress tolerance and survival. In this review, different enzymatic and non-enzymatic mechanisms to counteract the effect of nitrosative stress in Escherichia coli have been discussed and a hypothesis for the working mechanism of hybrid cluster protein that helps to combat nitrosative stress has been proposed. Here, we have tried to give a clear scenario about the mode of action of stress-responsive elements present in Escherichia coli.

Mots clés

  • nitrosative stress
  • protein tyrosine nitration
  • reactive nitrogen species
  • stress response

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