Zeitschriften und Ausgaben

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Volumen 61 (2022): Heft 2 (June 2022)

Volumen 61 (2022): Heft 1 (March 2022)

Volumen 60 (2021): Heft 3 (January 2021)

Volumen 60 (2021): Heft 2 (January 2021)

Volumen 60 (2021): Heft 1 (January 2021)

Volumen 59 (2020): Heft 4 (December 2020)

Volumen 59 (2020): Heft 3 (January 2020)

Volumen 59 (2020): Heft 2 (January 2020)

Volumen 59 (2020): Heft 1 (January 2020)

Volumen 58 (2019): Heft 4 (January 2019)

Volumen 58 (2019): Heft 3 (January 2019)

Volumen 58 (2019): Heft 2 (January 2019)

Volumen 58 (2019): Heft 1 (January 2019)

Volumen 57 (2018): Heft 4 (January 2018)

Volumen 57 (2018): Heft 3 (January 2018)

Volumen 57 (2018): Heft 2 (January 2018)

Volumen 57 (2018): Heft 1 (January 2018)

Volumen 56 (2017): Heft 4 (January 2017)

Volumen 56 (2017): Heft 3 (January 2017)

Volumen 56 (2017): Heft 2 (January 2017)

Volumen 56 (2017): Heft 1 (January 2017)

Zeitschriftendaten
Format
Zeitschrift
eISSN
2545-3149
Erstveröffentlichung
01 Mar 1961
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch, Polieren

Suche

Volumen 61 (2022): Heft 2 (June 2022)

Zeitschriftendaten
Format
Zeitschrift
eISSN
2545-3149
Erstveröffentlichung
01 Mar 1961
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch, Polieren

Suche

3 Artikel
Uneingeschränkter Zugang

Grzyby Endofityczne w Roli Potencjalnych Producentów Związków Przeciwnowotworowych

Online veröffentlicht: 09 Jun 2022
Seitenbereich: 63 - 72

Zusammenfassung

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Schlüsselwörter

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Uneingeschränkter Zugang

Wybrane Zoonozy Bakteryjne Przenoszone przez Mleko Surowe

Online veröffentlicht: 09 Jun 2022
Seitenbereich: 73 - 80

Zusammenfassung

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Schlüsselwörter

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Uneingeschränkter Zugang

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in Escherichia coli

Online veröffentlicht: 25 Jun 2022
Seitenbereich: 81 - 93

Zusammenfassung

Abstract

Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different macromolecules in vivo and result in the inactivation of these molecules. But the mechanism to counteract the effect of nitrosative stress is poorly understood. Escherichia coli is one of the best understood and well-studied microorganism. Although several studies have been reported on Escherichia coli to characterize the effect of various stress response but fewer works are there to see the effect of nitrosative stress. Escherichia coli encounter numerous stresses during its growth, survival, and infection. They respond to various stress conditions by activating common regulator proteins and thiols. These stress conditions result in the accumulation of these regulator proteins and thiols that allow cells to adjust to specific stress situations, conferring stress tolerance and survival. In this review, different enzymatic and non-enzymatic mechanisms to counteract the effect of nitrosative stress in Escherichia coli have been discussed and a hypothesis for the working mechanism of hybrid cluster protein that helps to combat nitrosative stress has been proposed. Here, we have tried to give a clear scenario about the mode of action of stress-responsive elements present in Escherichia coli.

Schlüsselwörter

  • nitrosative stress
  • protein tyrosine nitration
  • reactive nitrogen species
  • stress response
3 Artikel
Uneingeschränkter Zugang

Grzyby Endofityczne w Roli Potencjalnych Producentów Związków Przeciwnowotworowych

Online veröffentlicht: 09 Jun 2022
Seitenbereich: 63 - 72

Zusammenfassung

Abstract

Medicines derived mostly from natural sources have played a major role in cancer chemotherapy for over 50 years. Against numerous ailments, plants have served as a source of bioactive compounds for centuries. However, it is not the plants themselves, but the microorganisms associated with them that offer material and products with high therapeutic potential. Endophytes are organisms that colonize internal plant tissues without causing disease symptoms. They constitute an endosymbiotic group of microorganisms which are the source of innovative natural products for use in modern industry, agriculture and medicine, indicating potential therapeutic properties, including anti-cancer and antimicrobial, as well as anti-inflammatory and antioxidant properties. Endophytic fungi are a rich source of bioactive metabolites that can be manipulated to obtain to produce desirable the desired new analogs used in chemotherapy, including: taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, cytochalasin and many others. This review gives provides examples of anti-cancer compound production by endophytic fungi published since 2015.

Schlüsselwörter

  • endophytic fungi
  • fungal anticancer metabolites

Słowa kluczowe

  • grzyby endofityczne
  • grzybicze metabolity przeciwnowotworowe
Uneingeschränkter Zugang

Wybrane Zoonozy Bakteryjne Przenoszone przez Mleko Surowe

Online veröffentlicht: 09 Jun 2022
Seitenbereich: 73 - 80

Zusammenfassung

Abstract

Raw milk, that has not been heat-treated, can be an important source of pathogenic microorganisms transmitted via the food route, mainly such as: pathogenic strains of Escherichia coli, bacteria of the genus Salmonella, some fecal streptococci or Listeria monocyto­genes. The most dangerous of the pathogens associated with raw milk is VTEC E. coli, which produces verocytotoxins – especially the O157:H7 strain. Enterococcus spp. is a frequent factor of bovine mastitis and therefore is often found in raw milk, thus posing a risk to consumers. Consuming raw milk is a good choice as long as we have a guarantee of a high level of hygienic sourcing.

Schlüsselwörter

  • pathogenic bacteria
  • raw milk
  • zoonoses

Słowa kluczowe

  • bakterie patogenne
  • mleko surowe
  • zoonozy
Uneingeschränkter Zugang

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in Escherichia coli

Online veröffentlicht: 25 Jun 2022
Seitenbereich: 81 - 93

Zusammenfassung

Abstract

Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different macromolecules in vivo and result in the inactivation of these molecules. But the mechanism to counteract the effect of nitrosative stress is poorly understood. Escherichia coli is one of the best understood and well-studied microorganism. Although several studies have been reported on Escherichia coli to characterize the effect of various stress response but fewer works are there to see the effect of nitrosative stress. Escherichia coli encounter numerous stresses during its growth, survival, and infection. They respond to various stress conditions by activating common regulator proteins and thiols. These stress conditions result in the accumulation of these regulator proteins and thiols that allow cells to adjust to specific stress situations, conferring stress tolerance and survival. In this review, different enzymatic and non-enzymatic mechanisms to counteract the effect of nitrosative stress in Escherichia coli have been discussed and a hypothesis for the working mechanism of hybrid cluster protein that helps to combat nitrosative stress has been proposed. Here, we have tried to give a clear scenario about the mode of action of stress-responsive elements present in Escherichia coli.

Schlüsselwörter

  • nitrosative stress
  • protein tyrosine nitration
  • reactive nitrogen species
  • stress response

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