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Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder

Jianying Zeng

Jianying Zeng

  • School of Medicine, Jinan UniversityGuangdong Province, China
  • Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Zeng, Jianying
, 
Zilin Qin

Zilin Qin

  • School of Medicine, Jinan UniversityGuangdong Province, China
  • Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Qin, Zilin
, 
Liang Zhou

Liang Zhou

Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Zhou, Liang
, 
Gang Fang

Gang Fang

Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Fang, Gang
, 
Jibing Chen

Jibing Chen

Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Chen, Jibing
, 
Jialiang Li

Jialiang Li

Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Li, Jialiang
, 
Lizhi Niu

Lizhi Niu

  • School of Medicine, Jinan UniversityGuangdong Province, China
  • Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Niu, Lizhi
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Bing Liang

Bing Liang

Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Liang, Bing
 and 
Kecheng Xu

Kecheng Xu

Fuda Cancer Hospital, Jinan University School of MedicineGuangdong Province, China
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Xu, Kecheng
  
Jan 14, 2016
Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder's Cover Image
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Article Category: Research Article
Published Online: Jan 14, 2016
Page range: 40 - 46
Received: Aug 26, 2016
Accepted: Nov 19, 2016
DOI: https://doi.org/10.1515/raon-2017-0003
Keywords
© 2017 Jianying Zeng, Zilin Qin, Liang Zhou, Gang Fang, Jibing Chen, Jialiang Li, Lizhi Niu, Bing Liang, Kecheng Xu
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Photos of the liver and gallbladder bef ore cryoablation. (A) Cryoprobe insertion. (B) Ice ball formation. Th e white arrows in (A and B) indicate the gallbladder. The black arrow in (A) indicates the cryoprobe.
Photos of the liver and gallbladder bef ore cryoablation. (A) Cryoprobe insertion. (B) Ice ball formation. Th e white arrows in (A and B) indicate the gallbladder. The black arrow in (A) indicates the cryoprobe.
Photos of the liver and gallbladder before IRE ablation. (A) Electrode placement. (B) Immediately after the probes are pulled out, the gallbladder and liver do not show any significant changes. The white arrows in (A and B) indicate the gallbladder. The black arrows in (A) indicate the IRE probes. The blue arrows in (B) indicate the insertion sites of the two monopolar IRE probes.
Photos of the liver and gallbladder before IRE ablation. (A) Electrode placement. (B) Immediately after the probes are pulled out, the gallbladder and liver do not show any significant changes. The white arrows in (A and B) indicate the gallbladder. The black arrows in (A) indicate the IRE probes. The blue arrows in (B) indicate the insertion sites of the two monopolar IRE probes.
Distance between two monopolar IRE probes. The two probes are 1.5 cm apart.
Distance between two monopolar IRE probes. The two probes are 1.5 cm apart.
Photos of the liver and gallbladder after cryoablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after cryoablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after IRE ablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after IRE ablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Pathological changes in the cryoablation (Cryo) and IRE ablation zones 7 days after ablation. (A) The top images show the ablated liver and gallbladder areas (magnification, 40×). The bottom images (A to E) show enlarged versions of the areas marked in the top images (magnification, 400×). (B) The top images and (F) show the ablated liver, gallbladder and common bile duct (magnification, 40×). The bottom images (A to D) show the enlarged versions of the areas marked in the top images (magnification, 400×).
Pathological changes in the cryoablation (Cryo) and IRE ablation zones 7 days after ablation. (A) The top images show the ablated liver and gallbladder areas (magnification, 40×). The bottom images (A to E) show enlarged versions of the areas marked in the top images (magnification, 400×). (B) The top images and (F) show the ablated liver, gallbladder and common bile duct (magnification, 40×). The bottom images (A to D) show the enlarged versions of the areas marked in the top images (magnification, 400×).

Sizes of liver and gallbladder lesions at 7 days after the ablation (X̅± s)

AblationMajor diameter of liver lesions (cm)Gallbladder lesions
methodsGallbladder side (n = 12)Diaphragm side (n = 12)P valueMajor diameter (cm)P value
Cryo1.5 ± 0.43.8 ± 0.8> 0.051.5 ± 0.4 (n = 8)> 0.05
IRE1.4 ± 0.44.1 ± 0.7> 0.050.8 ± 0.2 (n = 12)

Changes in aminotransferase and serum bilirubin levels over time (X̅± s)

Hepatic functionAblation methodd-1d-1d-3d-5d-7
ALT(U/L)RE38.35 ± 3.22167.05 ± 19.50214.83 ± 10.37119.60 ± 12.9968.25 ± 10.08
Cryo39.20 ± 3.90195.03 ± 9.75

P < 0.01, compared with the IRE group

289.58 ± 12.81

P < 0.01, compared with the IRE group

142.35 ± 57.85

P < 0.05

94.90 ± 9.78

P < 0.05

AST(U/L)IRE34.10 ± 0.8647.64 ± 0.6960.21 ± 2.5546.78 ± 1.7131.05 ± 0.43
Cryo35.26 ± 2.4560.11 ± 3.44

P < 0.01, compared with the IRE group

79.12 ± 2.58

P < 0.01, compared with the IRE group

52.80 ± 3.41

P < 0.05

37.41 ± 2.50

P < 0.05

Serum bilirubin(μmol/L)RE8.08 ± 2.1926.01 ± 3.6835.15 ± 5.7029.09 ± 3.2721.41 ± 3.39
Cryo7.59 ± 2.0132.72 ± 4.08

P < 0.01, compared with the IRE group

37.34 ± 6.14

P < 0.05

35.88 ± 4.28

P < 0.01, compared with the IRE group

25.86 ± 5.37

P < 0.05

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