<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2017-0006_s_001_w2aab3b8c81b1b7b1aab1c16b1Aa"><h3>Background</h3><p>The ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety and efficacy of irreversible electroporation (IRE) and cryoablation in rabbit livers at a location close to the gallbladder.</p></sec><sec id="j_raon-2017-0006_s_002_w2aab3b8c81b1b7b1aab1c16b2Aa"><h3>Materials and methods</h3><p>We performed cryoablation (n = 12) and IRE (n = 12) of the area of the liver close to the gallbladder in 24 New Zealand white rabbits in order to ensure gallbladder damage. Serum aminotransferase and serum bilirubin levels were measured before and after the ablation. Histopathological examination of the ablation zones in the liver and gallbladder was performed on the 7<sup>th</sup> day after the ablation.</p></sec><sec id="j_raon-2017-0006_s_003_w2aab3b8c81b1b7b1aab1c16b3Aa"><h3>Result</h3><p>Seven days after the ablation, all 24 animals were alive. Gallbladder perforation did not occur in the IRE group; only mucosal epithelial necrosis and serous layer edema were found in this group. Gallbladder perforation occurred in four rabbits in the cryoablation group. Serum aminotransferase and serum bilirubin levels obviously increased in both groups by Day 3 and decreased gradually thereafter. The elevation in aminotransferase and bilirubin levels was greater in the cryoablation group than the IRE group. Pathological examination revealed complete necrosis of the liver parenchyma from the ablation center to the gallbladder in both groups, but bile duct and granulation tissue hyperplasia were observed in only the IRE group. Full-thickness gallbladder-wall necrosis was seen in the cryoablation group.</p></sec><sec id="j_raon-2017-0006_s_004_w2aab3b8c81b1b7b1aab1c16b4Aa"><h3>Conclusions</h3><p>For ablation of the liver area near the gallbladder, IRE is superior to cryoablation, both in terms of safety (no gallbladder perforation in the IRE group) and efficacy (complete necrosis and rapid recovery in the IRE group).</p></sec></abstract>

BackgroundThe ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety and efficacy of irreversible electroporation (IRE) and cryoablation in rabbit livers at a location close to the gallbladder.Materials and methodsWe performed cryoablation (n = 12) and IRE (n = 12) of the area of the liver close to the gallbladder in 24 New Zealand white rabbits in order to ensure gallbladder damage. Serum aminotransferase and serum bilirubin levels were measured before and after the ablation. Histopathological examination of the ablation zones in the liver and gallbladder was performed on the 7th day after the ablation.ResultSeven days after the ablation, all 24 animals were alive. Gallbladder perforation did not occur in the IRE group; only mucosal epithelial necrosis and serous layer edema were found in this group. Gallbladder perforation occurred in four rabbits in the cryoablation group. Serum aminotransferase and serum bilirubin levels obviously increased in both groups by Day 3 and decreased gradually thereafter. The elevation in aminotransferase and bilirubin levels was greater in the cryoablation group than the IRE group. Pathological examination revealed complete necrosis of the liver parenchyma from the ablation center to the gallbladder in both groups, but bile duct and granulation tissue hyperplasia were observed in only the IRE group. Full-thickness gallbladder-wall necrosis was seen in the cryoablation group.ConclusionsFor ablation of the liver area near the gallbladder, IRE is superior to cryoablation, both in terms of safety (no gallbladder perforation in the IRE group) and efficacy (complete necrosis and rapid recovery in the IRE group).

Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder

Radiology and Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

BackgroundThe ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety...

Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder

Article Category: Research Article

Published Online: Jan 14, 2016

Page range: 40 - 46

Received: Aug 26, 2016

Accepted: Nov 19, 2016

DOI: https://doi.org/10.1515/raon-2017-0003

© 2017 Jianying Zeng, Zilin Qin, Liang Zhou, Gang Fang, Jibing Chen, Jialiang Li, Lizhi Niu, Bing Liang, Kecheng Xu

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.