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Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder

Jianying Zeng
Jianying Zeng
, 
Zilin Qin
Zilin Qin
, 
Liang Zhou
Liang Zhou
, 
Gang Fang
Gang Fang
, 
Jibing Chen
Jibing Chen
, 
Jialiang Li
Jialiang Li
, 
Lizhi Niu
Lizhi Niu
, 
Bing Liang
Bing Liang
 und 
Kecheng Xu
Kecheng Xu
   | 14. Jan. 2016
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Article Category: Research Article
Online veröffentlicht: 14. Jan. 2016
Seitenbereich: 40 - 46
Eingereicht: 26. Aug. 2016
Akzeptiert: 19. Nov. 2016
DOI: https://doi.org/10.1515/raon-2017-0003
© 2017 Jianying Zeng, Zilin Qin, Liang Zhou, Gang Fang, Jibing Chen, Jialiang Li, Lizhi Niu, Bing Liang, Kecheng Xu
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Photos of the liver and gallbladder bef ore cryoablation. (A) Cryoprobe insertion. (B) Ice ball formation. Th e white arrows in (A and B) indicate the gallbladder. The black arrow in (A) indicates the cryoprobe.
Photos of the liver and gallbladder bef ore cryoablation. (A) Cryoprobe insertion. (B) Ice ball formation. Th e white arrows in (A and B) indicate the gallbladder. The black arrow in (A) indicates the cryoprobe.

Photos of the liver and gallbladder before IRE ablation. (A) Electrode placement. (B) Immediately after the probes are pulled out, the gallbladder and liver do not show any significant changes. The white arrows in (A and B) indicate the gallbladder. The black arrows in (A) indicate the IRE probes. The blue arrows in (B) indicate the insertion sites of the two monopolar IRE probes.
Photos of the liver and gallbladder before IRE ablation. (A) Electrode placement. (B) Immediately after the probes are pulled out, the gallbladder and liver do not show any significant changes. The white arrows in (A and B) indicate the gallbladder. The black arrows in (A) indicate the IRE probes. The blue arrows in (B) indicate the insertion sites of the two monopolar IRE probes.

Distance between two monopolar IRE probes. The two probes are 1.5 cm apart.
Distance between two monopolar IRE probes. The two probes are 1.5 cm apart.

Photos of the liver and gallbladder after cryoablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after cryoablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.

Photos of the liver and gallbladder after IRE ablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after IRE ablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.

Pathological changes in the cryoablation (Cryo) and IRE ablation zones 7 days after ablation. (A) The top images show the ablated liver and gallbladder areas (magnification, 40×). The bottom images (A to E) show enlarged versions of the areas marked in the top images (magnification, 400×). (B) The top images and (F) show the ablated liver, gallbladder and common bile duct (magnification, 40×). The bottom images (A to D) show the enlarged versions of the areas marked in the top images (magnification, 400×).
Pathological changes in the cryoablation (Cryo) and IRE ablation zones 7 days after ablation. (A) The top images show the ablated liver and gallbladder areas (magnification, 40×). The bottom images (A to E) show enlarged versions of the areas marked in the top images (magnification, 400×). (B) The top images and (F) show the ablated liver, gallbladder and common bile duct (magnification, 40×). The bottom images (A to D) show the enlarged versions of the areas marked in the top images (magnification, 400×).

Sizes of liver and gallbladder lesions at 7 days after the ablation (X̅± s)

AblationMajor diameter of liver lesions (cm)Gallbladder lesions
methodsGallbladder side (n = 12)Diaphragm side (n = 12)P valueMajor diameter (cm)P value
Cryo1.5 ± 0.43.8 ± 0.8> 0.051.5 ± 0.4 (n = 8)> 0.05
IRE1.4 ± 0.44.1 ± 0.7> 0.050.8 ± 0.2 (n = 12)

Changes in aminotransferase and serum bilirubin levels over time (X̅± s)

Hepatic functionAblation methodd-1d-1d-3d-5d-7
ALT(U/L)RE38.35 ± 3.22167.05 ± 19.50214.83 ± 10.37119.60 ± 12.9968.25 ± 10.08
Cryo39.20 ± 3.90195.03 ± 9.75

P < 0.01, compared with the IRE group

289.58 ± 12.81

P < 0.01, compared with the IRE group

142.35 ± 57.85

P < 0.05

94.90 ± 9.78

P < 0.05

AST(U/L)IRE34.10 ± 0.8647.64 ± 0.6960.21 ± 2.5546.78 ± 1.7131.05 ± 0.43
Cryo35.26 ± 2.4560.11 ± 3.44

P < 0.01, compared with the IRE group

79.12 ± 2.58

P < 0.01, compared with the IRE group

52.80 ± 3.41

P < 0.05

37.41 ± 2.50

P < 0.05

Serum bilirubin(μmol/L)RE8.08 ± 2.1926.01 ± 3.6835.15 ± 5.7029.09 ± 3.2721.41 ± 3.39
Cryo7.59 ± 2.0132.72 ± 4.08

P < 0.01, compared with the IRE group

37.34 ± 6.14

P < 0.05

35.88 ± 4.28

P < 0.01, compared with the IRE group

25.86 ± 5.37

P < 0.05

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