<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 <italic>μ</italic>m particle size with 0.512 m<sup>2</sup>/g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profiles are fitted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer–Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid.</p></abstract>

The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 μm particle size with 0.512 m2/g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profiles are fitted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer–Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid.

Encapsulation of L-ascorbic acid <italic>via</italic> polycaprolactone-polyethylene glycol-casein bioblends

Istanbul Technical University, Chemical and Metallurgical Engineering Faculty, Chemical Engineering Department, 34469, Maslak-Istanbul, Turkey

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Encapsulation of L-ascorbic acid  polycaprolactone-polyethylene glycol-casein bioblends

The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug...

Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends

Data publikacji: 27 lis 2015

Zakres stron: 32 - 36

DOI: https://doi.org/10.1515/pjct-2015-0065

Słowa kluczowe
casein, drug encapsulation, L-ascorbic acid, polycaprolactone, polyethylene glycol, spray dryer

© 2015 Erhan Ozsagiroglu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends

Data publikacji: 27 lis 2015

Zakres stron: 32 - 36

DOI: https://doi.org/10.1515/pjct-2015-0065

Słowa kluczowecasein, drug encapsulation, L-ascorbic acid, polycaprolactone, polyethylene glycol, spray dryer

© 2015 Erhan Ozsagiroglu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
casein, drug encapsulation, L-ascorbic acid, polycaprolactone, polyethylene glycol, spray dryer