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Volume 30 (2017): Issue 4 (December 2017)
4th International Conference “Advances in Surgical Oncology”: Cytoreductive Surgery & Hyperthermic Intraperitoneal Chemotherapy Lublin

Volume 30 (2017): Issue 3 (December 2017)

Volume 30 (2017): Issue 2 (June 2017)

Volume 30 (2017): Issue 1 (March 2017)

Volume 29 (2016): Issue 4 (December 2016)

Volume 29 (2016): Issue 3 (September 2016)

Volume 29 (2016): Issue 2 (June 2016)

Volume 29 (2016): Issue 1 (April 2016)

Volume 28 (2015): Issue 4 (December 2015)

Volume 28 (2015): Issue 3 (September 2015)

Volume 28 (2015): Issue 2 (June 2015)

Volume 28 (2015): Issue 1 (March 2015)

Volume 27 (2014): Issue 4 (December 2014)

Volume 27 (2014): Issue 3 (September 2014)

Volume 27 (2014): Issue 2 (June 2014)

Volume 27 (2014): Issue 1 (June 2014)

Journal Details
Format
Journal
eISSN
2300-6676
ISSN
2084-980X
First Published
30 May 2014
Publication timeframe
4 times per year
Languages
English

Search

Volume 27 (2014): Issue 4 (December 2014)

Journal Details
Format
Journal
eISSN
2300-6676
ISSN
2084-980X
First Published
30 May 2014
Publication timeframe
4 times per year
Languages
English

Search

15 Articles
Open Access

The heparan sulfate and its diverse biological activities

Published Online: 03 Mar 2015
Page range: 209 - 212

Abstract

Abstract

Heparan sulfate (HS) is one of the most common glycosaminoglycan (GAG) in mammals. It is composed of relatively simple disaccharide subunits, which, by further modification, such as sulfation and epimerization, potentially offer huge diversity in biological function. GAG chains of different length, different patterns of sulfation, and other modifications, depending on location, generate unique forms. Due to polyanion charges, these compounds can interact with other molecules, such as proteins, cytokines, chemokines and growth factors, both on the cell surface and inside the extracellular matrix. These interactions serve protective and storage functions for the compounds, safeguarding them from proteolysis. In this way, HS is involved in numerous signaling pathways, and in growth and differentiation processes. Disrupted interactions between the HS and growth factors, cytokines or other proteins have been observed in various disorders, among these Alzheimer’s disease, epilepsy, atherosclerosis, diabetes, and cancer processes. Detailed knowledge of these relationships at the molecular level will allow researchers to understand the mechanisms underlying these disorders and enable the development of effective therapeutic strategies.

Keywords

  • heparan sulfate
  • glycosaminoglycans
  • proteoglycans
  • atherosclerosis
  • lipoproteins
Open Access

Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions

Published Online: 03 Mar 2015
Page range: 213 - 216

Abstract

Abstract

In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.

Keywords

  • hydrogen peroxide
  • urea
  • stability
  • activation energy
Open Access

Impact of the grasping test on women’s cardiovascular systems, and the possibility of replacing the orthostatic tolerance test with it

Published Online: 03 Mar 2015
Page range: 217 - 219

Abstract

Abstract

The aim of this study was to test the impact of the Grasping Test (GT) on the female cardiovascular system and to ascertain the possibility of using this to replace the Orthostatic Tolerance Test (OT). In this study, 15 volunteer female students were examined, and their physiological parameters - their systolic (SBP) and diastolic blood pressures (DBP), and their heart rates (HR) - were compared. We found that the Orthostatic Tolerance Test (changing the position of the body from recumbent to upright) and the Grasping Test induced meaningful but similar changes in the functioning of the women’s cardiovascular system. The results confirm that there were significant similarities between the cardiovascular system measurements as produced through the Orthostatic Tolerance Test and the Grasping Test. The possibility of introducing the procedure into clinical practice is a crucial factor for continuing our research in the wider population.

Keywords

  • hypokinesia
  • orthostatic intolerance
  • Orthostatic Tolerance Test
  • Grasping Test
Open Access

The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

Published Online: 03 Mar 2015
Page range: 220 - 223

Abstract

Abstract

The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal cells. As a result, redox disorders and secondary oxidative stress are developed. Doxorubicin ROS generation is attributed to enzymes that are produced abundantly in hepatocytes. Oxidative stress has been a well-known risk factor of doxorubicin-related toxicity. However, in addition, according to the data collected in the last decade, changes in thyroxin status can propagate ROS generation, and, thus, initiate the doxorubicin hepatic effect. Moreover, both compounds have an impact on the cell metabolism. The aim of the study was to verify the thesis that thyroxin can modulate the effect of doxorubicin with regard to redox status and lipid metabolism disorders. In our work, we determined the ratio of NADP+/ NADPH and NAD+/NADH in liver homogenates, blood ketone bodies and triglycerides in the liver and blood in rats treated with doxorubicin and thyroxin. Our results indicate that thyroxin has an insignificant effect on NAD+/NADH, NADP+/NADPH ratios and on hepatic and blood triglycerides. Moreover, thyroxin administration normalized the level of blood ketone bodies that was disturbed by doxorubicin.

Keywords

  • doxorubicin
  • thyroxin
  • liver
  • redox equilibrium
  • lipid metabolism
Open Access

Physical properties and caffeine release from creams prepared with different oils

Published Online: 03 Mar 2015
Page range: 224 - 228

Abstract

Abstract

Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coconut oil, Sweet almond oil and Jojoba oil), containing 5% of caffeine, and compared the release of the substance from the obtained preparations. Initially, all of the creams were subjected to a variety of physical tests, among these being for slippage and spreadability. Furthermore, their rheological properties were evaluated. Subsequently, the creams were tested for caffeine release. In the slippage and spreadability tests, the coconut oil-based cream was revealed as having the best parameters. However, the rheological tests showed that all of the preparations had the pseudoplastic character of flowing according to the Ostwald de Waele power law model. The power low index (n) for all the preparations was from 0.2467-0.3179 at 20°C and 0.2821-0.3754 at 32°C. At 20°C, the Sesame oil-, Walnut oil-, Sweet almond oil- and Jojoba oil-based creams were thixotropic, but at 32°C, thixotropy appeared only in the Walnut oil-based creams.

The release studies, conducted by way of an extracting chamber (according to Polish Pharmacoeia IX) in the Paddle Apparatus (according to Polish Pharamcopoeia IX), showed that the amount of released caffeine is the largest in the case of Jojoba oil-based cream, at 85.23% ± 0.8% (SD), and the least in the case of Coconut oil-based cream, at 62,78%± 0.87% (SD).

Keywords

  • caffeine release
  • creams
  • rheology
Open Access

Apoptotic factors in physiological and pathological processes of teeth and periodontal tissues – literature review

Published Online: 03 Mar 2015
Page range: 229 - 233

Abstract

Abstract

Apoptosis is a physiological process that occurs in the human body throughout the entire life span. This process can be seen in the tissues of the stomatognathic system. A disorder in such programmed cell death processes leads to the development of pathological lesions. Among these are inflammation, osteolytic lesions and neoplastic hyperplasia. We put forward that future studies should concentrate on how to use the knowledge of apoptotic processes and their inhibitors in therapeutic processes involving the stomatognathic system.

Keywords

  • apoptosis
  • Bcl-2
  • Ki-67
  • p53
  • follicular cyst
  • keratocyst
Open Access

An unusual origin of the right subclavian artery – arteria lusoria

Published Online: 03 Mar 2015
Page range: 234 - 236

Abstract

Abstract

The aortic arch usually gives off three major arterial branches: the brachiocephalic trunk, the left common carotid artery and the left subclavian artery. The most frequently occurring developmental variations of arterial trunks origins are a joined brachiocephalic and left common carotid artery origin, the left vertebral artery branching from the aortic arch, a double aortic arch, and a change of sequence of branching arteries. The current report presents the rare asymptomatic situation of the right subclavian artery originating as the last individual branching from the aortic arch. This abnormality was accidentally discovered in a computed tomography examination of a 69-year old male patient. The examination showed that the artery went towards the neck posteriorly from the trachea. The anatomical anomaly was interpreted as being an arteria lusoria.

Keywords

  • aortic arch
  • subclavian artery
  • arteria lusoria
  • angioCT
  • anatomical variation
Open Access

The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis

Published Online: 03 Mar 2015
Page range: 237 - 239

Abstract

Abstract

Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integrity, increase permeability and promote an influx of bacteria and toxins. Alterations in gastrointestinal permeability are considered as an initial step in the development of lesions of the gastric mucosa such as erosions and ulcers. The mechanisms underlying the ability of NSAIDs to cause ulceration in the stomach and proximal duodenum are well understood and this injury can be largely be prevented through suppression of gastric acid secretion. However, our work showed that 28-day administration of the anti-secretory preparation pantoprazole (20 mg 2 times per day) resulted in a statistically significant increase of dysbiosis. Monitoring of patients with osteoarthritis who used NSAIDs for more than three months showed that, in comparison to the situation before the beginning of treatment, changes in colonic microbiota were present. Multiprobiotic “Symbiter® acidophilic concentrated” introduced simultaneously with pantoprazole during 20 days prevented formation of dysbiotic changes and led to the quicker healing of gastric mucous healing, in comparison with patients who used only pantoprazole alone. Moreover, it brought about total healing of the gastric mucosa within 4 weeks from the beginning of treatment.

Keywords

  • NSAID-gastropathy
  • NSAID-enteropathy
  • colonic microbiota
  • pantoprazole
  • probiotics
Open Access

Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Published Online: 03 Mar 2015
Page range: 240 - 242

Abstract

Abstract

This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.

Keywords

  • liver
  • hepatitis
  • “Phytovenol” capsules
  • hepatoprotective action
Open Access

Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats

Published Online: 03 Mar 2015
Page range: 243 - 245

Abstract

Abstract

Considering the association between microflora and obesity, and the significantly higher prevalence of non-alcoholic fatty liver disease (NAFLD) in obese people, the aim of our study was to investigate the preventive effect of multiprobiotics on the monosodium glutamate (MSG) induced NAFLD model, in rats. The work was carried out on 60 rats placed into three groups: the Control group, the MSG-group and the MSG-probiotic group. The MSG-group and the MSG-probiotic group were injected with 4 mg/g of MSG subcutaneously neonatally on the 2nd-10th days of life. The MSG-probiotic rats were also treated with 140 mg/kg of multiprobiotic “Symbiter” from the 4th week of life. In the 4-month-old rats, biochemical and morphological changes in liver were assessed, and steatosis was confirmed by the NAFLD activity score (NAS). Our results reveal that the multiprobiotic lowered total NAS, the degree of steatosis and the liver lobular inflammation caused by MSG. It also brought about decreased liver total lipids and triglycerids content, as well as decreased visceral adipose tissue mass. However, there was no difference in the liver serum biochemical indicators between all experimental groups. The obtained data does suggest the efficacy of probiotics in the prevention of NAFLD.

Keywords

  • monosodium glutamate
  • non-alcoholic fatty liver disease
  • multiprobiotic
Open Access

A new diagnostic perspective – hyperglycemia in pregnancy – as of the year, 2014

Published Online: 03 Mar 2015
Page range: 246 - 249

Abstract

Abstract

Gestational Diabetes Mellitus (GDM) is a growing epidemiological problem, and it is currently the most common metabolic disorder in pregnancy, as it affects approximately 2-6% of all pregnant women. In 2014, the Polish Diabetic Association introduced significant changes in the diagnosis of hyperglycemia as first diagnosed in pregnancy, based on the recommendations of the IADPSG of 2010 and WHO of 2013. There are now two categories: diabetes in pregnancy, and GDM. These involve different degrees of severity of metabolic complications for the mother and the growing fetus. Establishing a new diagnostic criterion is significant because of the negative impact of hyperglycemia on the fetus (especially in the first trimester), the increased prevalence of malformations or the possibility of spontaneous abortions in early pregnancy.

Keywords

  • Gestational Diabetes Mellitus
  • GDM
  • diabetes in pregnancy
Open Access

Prevalence of Polyomaviruses in Polish patients

Published Online: 03 Mar 2015
Page range: 250 - 252

Abstract

Abstract

The aim of our study was to investigate the prevalence of new polyomaviruses KIPyV and WUPyV in the Polish population in the Lublin region. In it, we demonstrated that the prevalence of this viruses is low - 1.1% WU and 3.4% KI. The viruses are most commonly detected in materials from the respiratory tract, both in children and the elderly. Polyomaviruses KI and WU in co-infection, often occur with other respiratory viruses (influenza, enterovirus).

Keywords

  • Polyomaviruses KI and WU
  • respiratory tract
  • co-infection
Open Access

Cigarette smoking and dental implant tooth replacement therapy: A questionnaire survey among patients receiving implant prosthetic treatment

Published Online: 03 Mar 2015
Page range: 253 - 257

Abstract

Abstract

Chronic nicotinism has negative effects, both local and systemic. Its local effects are related to both the immediate thermal influence, as well as the toxic action of the substances contained in the smoke. In addition, the microflora colonizing dental plague is changed. The damage and the inflammatory processes that are incurred, affect the bone tissue of the alveolar processes, the mucosa, gums, and the tooth enamel. In this study, the tobacco smoking-related profile of patients being treated by way of implants was determined. Moreover, the relationship between cigarette smoking and pain sensation was assessed in patients undergoing surgical and prosthetic procedures in the oral cavity. The questionnaire survey covered 464 patients receiving prosthetic treatment at the “Dental” Non-Public Health Care Centre in Tomaszow Mazowiecki. The patients answered questions concerning their sex, age, the period of smoking, number of cigarettes smoked per day and the sensation of pain during bone reconstruction, implant placement and prosthetic procedures. The most numerous group of patients treated with implants were women: either non-smoking or smoking for less than 20 years at a level of less than 20 cigarettes a day, and men aged 40-60 years who have been smoking for over 20 years, at more than 20 cigarettes a day. The results of the survey reveal that non-smoking patients felt pain during bone reconstruction, implant placement and prosthetic procedures more frequently.

Keywords

  • nicotinism
  • implant prosthetic
  • pain
Open Access

Comparative validation of HPLC, densitometric and videodensitometric determination of lamotrigine in pharmaceutical

Published Online: 03 Mar 2015
Page range: 258 - 262

Abstract

Abstract

Simple, sensitive, precise and accurate HPLC, densitometric and videodensitometric methods for determination of lamotrigine in tablet forms were developed and validated. The HPLC method was carried out using a Symmetry C8 column and a mobile phase acetonitrile-phosphate buffer pH 2.80 (25:75, v/v), with a flow rate of 1 mL/min, and UV detection at 210 nm. Ethosuximide was used as the internal standard. Densitometric and videodensitometric analysis was performed on silica gel 60 F254 plates, in horizontal chambers, with methanol-chloroform-ammonia (25%) 1.5:7.5:1, (v/v) as mobile phase. Densitometric detection was performed at 225 nm and at 315 nm, and videodeoscanning at 254 nm. Calibration plots were constructed in the range 0.5-10 μg/spot, with good correlation coefficients r > 0.99 for both methods. The precision and accuracy of all elaborated methods were compared. Finally, the developed methods were applied for the quality control of lamotrigine tablets.

Keywords

  • densitometry
  • videodensitometry
  • lamotrigine
  • tablets
Open Access

The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Published Online: 03 Mar 2015
Page range: 263 - 266

Abstract

Abstract

Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch, in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet.

The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control.

Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.

Keywords

  • salivin
  • carbon tetrachloride
  • hepatoprotective activity
15 Articles
Open Access

The heparan sulfate and its diverse biological activities

Published Online: 03 Mar 2015
Page range: 209 - 212

Abstract

Abstract

Heparan sulfate (HS) is one of the most common glycosaminoglycan (GAG) in mammals. It is composed of relatively simple disaccharide subunits, which, by further modification, such as sulfation and epimerization, potentially offer huge diversity in biological function. GAG chains of different length, different patterns of sulfation, and other modifications, depending on location, generate unique forms. Due to polyanion charges, these compounds can interact with other molecules, such as proteins, cytokines, chemokines and growth factors, both on the cell surface and inside the extracellular matrix. These interactions serve protective and storage functions for the compounds, safeguarding them from proteolysis. In this way, HS is involved in numerous signaling pathways, and in growth and differentiation processes. Disrupted interactions between the HS and growth factors, cytokines or other proteins have been observed in various disorders, among these Alzheimer’s disease, epilepsy, atherosclerosis, diabetes, and cancer processes. Detailed knowledge of these relationships at the molecular level will allow researchers to understand the mechanisms underlying these disorders and enable the development of effective therapeutic strategies.

Keywords

  • heparan sulfate
  • glycosaminoglycans
  • proteoglycans
  • atherosclerosis
  • lipoproteins
Open Access

Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions

Published Online: 03 Mar 2015
Page range: 213 - 216

Abstract

Abstract

In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.

Keywords

  • hydrogen peroxide
  • urea
  • stability
  • activation energy
Open Access

Impact of the grasping test on women’s cardiovascular systems, and the possibility of replacing the orthostatic tolerance test with it

Published Online: 03 Mar 2015
Page range: 217 - 219

Abstract

Abstract

The aim of this study was to test the impact of the Grasping Test (GT) on the female cardiovascular system and to ascertain the possibility of using this to replace the Orthostatic Tolerance Test (OT). In this study, 15 volunteer female students were examined, and their physiological parameters - their systolic (SBP) and diastolic blood pressures (DBP), and their heart rates (HR) - were compared. We found that the Orthostatic Tolerance Test (changing the position of the body from recumbent to upright) and the Grasping Test induced meaningful but similar changes in the functioning of the women’s cardiovascular system. The results confirm that there were significant similarities between the cardiovascular system measurements as produced through the Orthostatic Tolerance Test and the Grasping Test. The possibility of introducing the procedure into clinical practice is a crucial factor for continuing our research in the wider population.

Keywords

  • hypokinesia
  • orthostatic intolerance
  • Orthostatic Tolerance Test
  • Grasping Test
Open Access

The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

Published Online: 03 Mar 2015
Page range: 220 - 223

Abstract

Abstract

The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal cells. As a result, redox disorders and secondary oxidative stress are developed. Doxorubicin ROS generation is attributed to enzymes that are produced abundantly in hepatocytes. Oxidative stress has been a well-known risk factor of doxorubicin-related toxicity. However, in addition, according to the data collected in the last decade, changes in thyroxin status can propagate ROS generation, and, thus, initiate the doxorubicin hepatic effect. Moreover, both compounds have an impact on the cell metabolism. The aim of the study was to verify the thesis that thyroxin can modulate the effect of doxorubicin with regard to redox status and lipid metabolism disorders. In our work, we determined the ratio of NADP+/ NADPH and NAD+/NADH in liver homogenates, blood ketone bodies and triglycerides in the liver and blood in rats treated with doxorubicin and thyroxin. Our results indicate that thyroxin has an insignificant effect on NAD+/NADH, NADP+/NADPH ratios and on hepatic and blood triglycerides. Moreover, thyroxin administration normalized the level of blood ketone bodies that was disturbed by doxorubicin.

Keywords

  • doxorubicin
  • thyroxin
  • liver
  • redox equilibrium
  • lipid metabolism
Open Access

Physical properties and caffeine release from creams prepared with different oils

Published Online: 03 Mar 2015
Page range: 224 - 228

Abstract

Abstract

Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coconut oil, Sweet almond oil and Jojoba oil), containing 5% of caffeine, and compared the release of the substance from the obtained preparations. Initially, all of the creams were subjected to a variety of physical tests, among these being for slippage and spreadability. Furthermore, their rheological properties were evaluated. Subsequently, the creams were tested for caffeine release. In the slippage and spreadability tests, the coconut oil-based cream was revealed as having the best parameters. However, the rheological tests showed that all of the preparations had the pseudoplastic character of flowing according to the Ostwald de Waele power law model. The power low index (n) for all the preparations was from 0.2467-0.3179 at 20°C and 0.2821-0.3754 at 32°C. At 20°C, the Sesame oil-, Walnut oil-, Sweet almond oil- and Jojoba oil-based creams were thixotropic, but at 32°C, thixotropy appeared only in the Walnut oil-based creams.

The release studies, conducted by way of an extracting chamber (according to Polish Pharmacoeia IX) in the Paddle Apparatus (according to Polish Pharamcopoeia IX), showed that the amount of released caffeine is the largest in the case of Jojoba oil-based cream, at 85.23% ± 0.8% (SD), and the least in the case of Coconut oil-based cream, at 62,78%± 0.87% (SD).

Keywords

  • caffeine release
  • creams
  • rheology
Open Access

Apoptotic factors in physiological and pathological processes of teeth and periodontal tissues – literature review

Published Online: 03 Mar 2015
Page range: 229 - 233

Abstract

Abstract

Apoptosis is a physiological process that occurs in the human body throughout the entire life span. This process can be seen in the tissues of the stomatognathic system. A disorder in such programmed cell death processes leads to the development of pathological lesions. Among these are inflammation, osteolytic lesions and neoplastic hyperplasia. We put forward that future studies should concentrate on how to use the knowledge of apoptotic processes and their inhibitors in therapeutic processes involving the stomatognathic system.

Keywords

  • apoptosis
  • Bcl-2
  • Ki-67
  • p53
  • follicular cyst
  • keratocyst
Open Access

An unusual origin of the right subclavian artery – arteria lusoria

Published Online: 03 Mar 2015
Page range: 234 - 236

Abstract

Abstract

The aortic arch usually gives off three major arterial branches: the brachiocephalic trunk, the left common carotid artery and the left subclavian artery. The most frequently occurring developmental variations of arterial trunks origins are a joined brachiocephalic and left common carotid artery origin, the left vertebral artery branching from the aortic arch, a double aortic arch, and a change of sequence of branching arteries. The current report presents the rare asymptomatic situation of the right subclavian artery originating as the last individual branching from the aortic arch. This abnormality was accidentally discovered in a computed tomography examination of a 69-year old male patient. The examination showed that the artery went towards the neck posteriorly from the trachea. The anatomical anomaly was interpreted as being an arteria lusoria.

Keywords

  • aortic arch
  • subclavian artery
  • arteria lusoria
  • angioCT
  • anatomical variation
Open Access

The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis

Published Online: 03 Mar 2015
Page range: 237 - 239

Abstract

Abstract

Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integrity, increase permeability and promote an influx of bacteria and toxins. Alterations in gastrointestinal permeability are considered as an initial step in the development of lesions of the gastric mucosa such as erosions and ulcers. The mechanisms underlying the ability of NSAIDs to cause ulceration in the stomach and proximal duodenum are well understood and this injury can be largely be prevented through suppression of gastric acid secretion. However, our work showed that 28-day administration of the anti-secretory preparation pantoprazole (20 mg 2 times per day) resulted in a statistically significant increase of dysbiosis. Monitoring of patients with osteoarthritis who used NSAIDs for more than three months showed that, in comparison to the situation before the beginning of treatment, changes in colonic microbiota were present. Multiprobiotic “Symbiter® acidophilic concentrated” introduced simultaneously with pantoprazole during 20 days prevented formation of dysbiotic changes and led to the quicker healing of gastric mucous healing, in comparison with patients who used only pantoprazole alone. Moreover, it brought about total healing of the gastric mucosa within 4 weeks from the beginning of treatment.

Keywords

  • NSAID-gastropathy
  • NSAID-enteropathy
  • colonic microbiota
  • pantoprazole
  • probiotics
Open Access

Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Published Online: 03 Mar 2015
Page range: 240 - 242

Abstract

Abstract

This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.

Keywords

  • liver
  • hepatitis
  • “Phytovenol” capsules
  • hepatoprotective action
Open Access

Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats

Published Online: 03 Mar 2015
Page range: 243 - 245

Abstract

Abstract

Considering the association between microflora and obesity, and the significantly higher prevalence of non-alcoholic fatty liver disease (NAFLD) in obese people, the aim of our study was to investigate the preventive effect of multiprobiotics on the monosodium glutamate (MSG) induced NAFLD model, in rats. The work was carried out on 60 rats placed into three groups: the Control group, the MSG-group and the MSG-probiotic group. The MSG-group and the MSG-probiotic group were injected with 4 mg/g of MSG subcutaneously neonatally on the 2nd-10th days of life. The MSG-probiotic rats were also treated with 140 mg/kg of multiprobiotic “Symbiter” from the 4th week of life. In the 4-month-old rats, biochemical and morphological changes in liver were assessed, and steatosis was confirmed by the NAFLD activity score (NAS). Our results reveal that the multiprobiotic lowered total NAS, the degree of steatosis and the liver lobular inflammation caused by MSG. It also brought about decreased liver total lipids and triglycerids content, as well as decreased visceral adipose tissue mass. However, there was no difference in the liver serum biochemical indicators between all experimental groups. The obtained data does suggest the efficacy of probiotics in the prevention of NAFLD.

Keywords

  • monosodium glutamate
  • non-alcoholic fatty liver disease
  • multiprobiotic
Open Access

A new diagnostic perspective – hyperglycemia in pregnancy – as of the year, 2014

Published Online: 03 Mar 2015
Page range: 246 - 249

Abstract

Abstract

Gestational Diabetes Mellitus (GDM) is a growing epidemiological problem, and it is currently the most common metabolic disorder in pregnancy, as it affects approximately 2-6% of all pregnant women. In 2014, the Polish Diabetic Association introduced significant changes in the diagnosis of hyperglycemia as first diagnosed in pregnancy, based on the recommendations of the IADPSG of 2010 and WHO of 2013. There are now two categories: diabetes in pregnancy, and GDM. These involve different degrees of severity of metabolic complications for the mother and the growing fetus. Establishing a new diagnostic criterion is significant because of the negative impact of hyperglycemia on the fetus (especially in the first trimester), the increased prevalence of malformations or the possibility of spontaneous abortions in early pregnancy.

Keywords

  • Gestational Diabetes Mellitus
  • GDM
  • diabetes in pregnancy
Open Access

Prevalence of Polyomaviruses in Polish patients

Published Online: 03 Mar 2015
Page range: 250 - 252

Abstract

Abstract

The aim of our study was to investigate the prevalence of new polyomaviruses KIPyV and WUPyV in the Polish population in the Lublin region. In it, we demonstrated that the prevalence of this viruses is low - 1.1% WU and 3.4% KI. The viruses are most commonly detected in materials from the respiratory tract, both in children and the elderly. Polyomaviruses KI and WU in co-infection, often occur with other respiratory viruses (influenza, enterovirus).

Keywords

  • Polyomaviruses KI and WU
  • respiratory tract
  • co-infection
Open Access

Cigarette smoking and dental implant tooth replacement therapy: A questionnaire survey among patients receiving implant prosthetic treatment

Published Online: 03 Mar 2015
Page range: 253 - 257

Abstract

Abstract

Chronic nicotinism has negative effects, both local and systemic. Its local effects are related to both the immediate thermal influence, as well as the toxic action of the substances contained in the smoke. In addition, the microflora colonizing dental plague is changed. The damage and the inflammatory processes that are incurred, affect the bone tissue of the alveolar processes, the mucosa, gums, and the tooth enamel. In this study, the tobacco smoking-related profile of patients being treated by way of implants was determined. Moreover, the relationship between cigarette smoking and pain sensation was assessed in patients undergoing surgical and prosthetic procedures in the oral cavity. The questionnaire survey covered 464 patients receiving prosthetic treatment at the “Dental” Non-Public Health Care Centre in Tomaszow Mazowiecki. The patients answered questions concerning their sex, age, the period of smoking, number of cigarettes smoked per day and the sensation of pain during bone reconstruction, implant placement and prosthetic procedures. The most numerous group of patients treated with implants were women: either non-smoking or smoking for less than 20 years at a level of less than 20 cigarettes a day, and men aged 40-60 years who have been smoking for over 20 years, at more than 20 cigarettes a day. The results of the survey reveal that non-smoking patients felt pain during bone reconstruction, implant placement and prosthetic procedures more frequently.

Keywords

  • nicotinism
  • implant prosthetic
  • pain
Open Access

Comparative validation of HPLC, densitometric and videodensitometric determination of lamotrigine in pharmaceutical

Published Online: 03 Mar 2015
Page range: 258 - 262

Abstract

Abstract

Simple, sensitive, precise and accurate HPLC, densitometric and videodensitometric methods for determination of lamotrigine in tablet forms were developed and validated. The HPLC method was carried out using a Symmetry C8 column and a mobile phase acetonitrile-phosphate buffer pH 2.80 (25:75, v/v), with a flow rate of 1 mL/min, and UV detection at 210 nm. Ethosuximide was used as the internal standard. Densitometric and videodensitometric analysis was performed on silica gel 60 F254 plates, in horizontal chambers, with methanol-chloroform-ammonia (25%) 1.5:7.5:1, (v/v) as mobile phase. Densitometric detection was performed at 225 nm and at 315 nm, and videodeoscanning at 254 nm. Calibration plots were constructed in the range 0.5-10 μg/spot, with good correlation coefficients r > 0.99 for both methods. The precision and accuracy of all elaborated methods were compared. Finally, the developed methods were applied for the quality control of lamotrigine tablets.

Keywords

  • densitometry
  • videodensitometry
  • lamotrigine
  • tablets
Open Access

The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Published Online: 03 Mar 2015
Page range: 263 - 266

Abstract

Abstract

Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch, in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet.

The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control.

Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.

Keywords

  • salivin
  • carbon tetrachloride
  • hepatoprotective activity

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