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Radiation-induced impairment of skeletal muscle regeneration

Maja Cemazar

Maja Cemazar

  • Faculty of Health Sciences, University of PrimorskaIzola, Slovenia
  • Institute of Oncology LjubljanaLjubljana, Slovenia
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Cemazar, Maja
 y 
Mihaela Jurdana

Mihaela Jurdana

Faculty of Health Sciences, University of PrimorskaIzola, Slovenia
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Jurdana, Mihaela
  
05 sept 2025
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Categoría del artículo: Research Article
Publicado en línea: 05 sept 2025
Páginas: 293 - 300
Recibido: 09 jul 2025
Aceptado: 16 jul 2025
DOI: https://doi.org/10.2478/raon-2025-0048
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© 2025 Maja Cemazar et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation
Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicina, Medicina Clínica, Medicina Interna, Hematología, oncología, Radiología
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