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Radiation-induced impairment of skeletal muscle regeneration

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Mihaela Jurdana

Jurdana, Mihaela

Sep 05, 2025

Radiation-induced impairment of skeletal muscle regeneration's Cover Image

Radiology and Oncology

Volume 59 (2025): Issue 3 (September 2025)

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Article Category: Research Article

Published Online: Sep 05, 2025

Page range: 293 - 300

Received: Jul 09, 2025

Accepted: Jul 16, 2025

DOI: https://doi.org/10.2478/raon-2025-0048

Keywords
skeletal muscle, muscle microenvironment, radiotherapy, muscle regeneration, melatonine

© 2025 Maja Cemazar et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts.
IR = irradiation — Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation

Language:: English

Publication timeframe:: 4 times per year
Journal Subjects:: Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology

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