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Radiation-induced impairment of skeletal muscle regeneration

Maja Cemazar

Maja Cemazar

  • Faculty of Health Sciences, University of PrimorskaIzola, Slovenia
  • Institute of Oncology LjubljanaLjubljana, Slovenia
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Cemazar, Maja
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Mihaela Jurdana

Mihaela Jurdana

Faculty of Health Sciences, University of PrimorskaIzola, Slovenia
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Jurdana, Mihaela
  
05 sept. 2025
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Catégorie d'article: Research Article
Publié en ligne: 05 sept. 2025
Pages: 293 - 300
Reçu: 09 juil. 2025
Accepté: 16 juil. 2025
DOI: https://doi.org/10.2478/raon-2025-0048
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© 2025 Maja Cemazar et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation
Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation
Langue:
Anglais
Périodicité:
4 fois par an
Sujets de la revue:
Médecine, Médecine clinique, Médecine interne, Hématologie, oncologie, Radiologie
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