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Radiation-induced impairment of skeletal muscle regeneration

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Mihaela Jurdana

Jurdana, Mihaela

05. Sept. 2025

Radiation-induced impairment of skeletal muscle regeneration's Cover Image

Radiology and Oncology

Band 59 (2025): Heft 3 (September 2025)

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Artikel-Kategorie: Research Article

Online veröffentlicht: 05. Sept. 2025

Seitenbereich: 293 - 300

Eingereicht: 09. Juli 2025

Akzeptiert: 16. Juli 2025

DOI: https://doi.org/10.2478/raon-2025-0048

Schlüsselwörter
skeletal muscle, muscle microenvironment, radiotherapy, muscle regeneration, melatonine

© 2025 Maja Cemazar et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts.
IR = irradiation — Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation

Sprache:: Englisch

Zeitrahmen der Veröffentlichung:: 4 Hefte pro Jahr
Fachgebiete der Zeitschrift:: Medizin, Klinische Medizin, Allgemeinmedizin, Innere Medizin, Hämatologie, Onkologie, Radiologie

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