Mutations of p53 gene in canine sweat gland carcinomas probably associated with UV radiation
Article Category: Review article
Published Online: Dec 20, 2021
Page range: 519 - 526
Received: Aug 13, 2021
Accepted: Dec 09, 2021
DOI: https://doi.org/10.2478/jvetres-2021-0070
Keywords
© 2021 A. Jasik et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Introduction
Apocrine sweat gland carcinomas (ASGCs) are rare malignant skin tumours in dogs and humans. The literature published so far focuses mostly on the clinico-epidemiological aspect of these tumours, but little is known about their pathogenesis. In this study we aimed to determine whether the
Material and Methods
Forty canine ASGCs were submitted to laser capture microdissection to isolate neoplastic cells, from which DNA was subsequently extracted. PCR amplification and sequencing of
Results
Sixteen mutations within the
Conclusion
The results of the present study indicate both the participation of the