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Tk-deleted pseudorabies virus retains high pathogenicity in rats

Lirong Zhang

Lirong Zhang

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Zhang, Lirong
, 
Keyue Ruan

Keyue Ruan

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Ruan, Keyue
, 
Guoju Sang

Guoju Sang

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Sang, Guoju
, 
Zhaoyang Xu

Zhaoyang Xu

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Xu, Zhaoyang
, 
Wu Tong

Wu Tong

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Tong, Wu
, 
Hai Yu

Hai Yu

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Yu, Hai
, 
Tongling Shan

Tongling Shan

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Shan, Tongling
, 
Fei Gao

Fei Gao

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Gao, Fei
, 
Liwei Li

Liwei Li

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Li, Liwei
, 
Ning Kong

Ning Kong

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
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Kong, Ning
, 
Guangzhi Tong

Guangzhi Tong

  • Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
  • Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou UniversityYangzhou, China
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Tong, Guangzhi
 and 
Hao Zheng

Hao Zheng

  • Shanghai Veterinary Research Institute, Chinese Academy of Agricultural SciencesShanghai, China
  • Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou UniversityYangzhou, China
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Zheng, Hao
  
Oct 26, 2021
Tk-deleted pseudorabies virus retains high pathogenicity in rats's Cover Image
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Article Category: Review article
Published Online: Oct 26, 2021
Page range: 401 - 405
Received: Apr 02, 2021
Accepted: Oct 12, 2021
DOI: https://doi.org/10.2478/jvetres-2021-0056
Keywords
© 2021 L. Zhang et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group) A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247; C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012
The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group) A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247; C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012

Fig. 2

The viral loads in different tissues of rats infected with PRV JS-2012 or SuHV-1ΔTK:247, respectively. The rats in each group (n = 6 per group) were infected with JS-2012 and SuHV-1 ΔTK:247 at different doses via intranasal or intramuscular inoculation. Ten tissues were collected from dead and surviving rats, and subjected to viral load analysis. Viral copies were determined by qPCR. Data are presented as the mean ± SD from six rats per group. *** - P < 0.001 versus other tissues of rats infected with 105 TCID50 PRV; ### - P < 0.001 and ## - P < 0.01 versus the same tissues of rats infected with other doses of PRV
The viral loads in different tissues of rats infected with PRV JS-2012 or SuHV-1ΔTK:247, respectively. The rats in each group (n = 6 per group) were infected with JS-2012 and SuHV-1 ΔTK:247 at different doses via intranasal or intramuscular inoculation. Ten tissues were collected from dead and surviving rats, and subjected to viral load analysis. Viral copies were determined by qPCR. Data are presented as the mean ± SD from six rats per group. *** - P < 0.001 versus other tissues of rats infected with 105 TCID50 PRV; ### - P < 0.001 and ## - P < 0.01 versus the same tissues of rats infected with other doses of PRV
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Life Sciences, Molecular Biology, Microbiology and Virology, Life Sciences, other, Medicine, Veterinary Medicine
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