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Tk-deleted pseudorabies virus retains high pathogenicity in rats

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26 oct. 2021

Tk-deleted pseudorabies virus retains high pathogenicity in rats's Cover Image

Journal of Veterinary Research

Édition 65 (2021): Edition 4 (Décembre 2021)

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Catégorie d'article: Review article

Publié en ligne: 26 oct. 2021

Pages: 401 - 405

Reçu: 02 avr. 2021

Accepté: 12 oct. 2021

DOI: https://doi.org/10.2478/jvetres-2021-0056

Mots clés
pseudorabies virus, thymidine kinase, rat

© 2021 L. Zhang et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group)
A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247;
C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012 — The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group) A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247; C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012

The viral loads in different tissues of rats infected with PRV JS-2012 or SuHV-1ΔTK:247, respectively. The rats in each group (n = 6 per group) were infected with JS-2012 and SuHV-1 ΔTK:247 at different doses via intranasal or intramuscular inoculation. Ten tissues were collected from dead and surviving rats, and subjected to viral load analysis. Viral copies were determined by qPCR. Data are presented as the mean ± SD from six rats per group. *** - P < 0.001 versus other tissues of rats infected with 105 TCID50 PRV; ### - P < 0.001 and ## - P < 0.01 versus the same tissues of rats infected with other doses of PRV

Langue:: Anglais

Périodicité:: 4 fois par an
Sujets de la revue:: Sciences de la vie, Biologie moléculaire, Microbiologie et virologie, Sciences de la vie, autres, Médecine, Médecine vétérinaire

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