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Journal of Veterinary Research
Volume 65 (2021): Numero 4 (December 2021)
Accesso libero
Tk-deleted pseudorabies virus retains high pathogenicity in rats
Lirong Zhang
Lirong Zhang
,
Keyue Ruan
Keyue Ruan
,
Guoju Sang
Guoju Sang
,
Zhaoyang Xu
Zhaoyang Xu
,
Wu Tong
Wu Tong
,
Hai Yu
Hai Yu
,
Tongling Shan
Tongling Shan
,
Fei Gao
Fei Gao
,
Liwei Li
Liwei Li
,
Ning Kong
Ning Kong
,
Guangzhi Tong
Guangzhi Tong
e
Hao Zheng
Hao Zheng
| 26 ott 2021
Journal of Veterinary Research
Volume 65 (2021): Numero 4 (December 2021)
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Article Category:
Review article
Pubblicato online:
26 ott 2021
Pagine:
401 - 405
Ricevuto:
02 apr 2021
Accettato:
12 ott 2021
DOI:
https://doi.org/10.2478/jvetres-2021-0056
Parole chiave
pseudorabies virus
,
thymidine kinase
,
rat
© 2021 L. Zhang et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fig. 1
The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group) A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247; C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012
Fig. 2
The viral loads in different tissues of rats infected with PRV JS-2012 or SuHV-1ΔTK:247, respectively. The rats in each group (n = 6 per group) were infected with JS-2012 and SuHV-1 ΔTK:247 at different doses via intranasal or intramuscular inoculation. Ten tissues were collected from dead and surviving rats, and subjected to viral load analysis. Viral copies were determined by qPCR. Data are presented as the mean ± SD from six rats per group. *** - P < 0.001 versus other tissues of rats infected with 105 TCID50 PRV; ### - P < 0.001 and ## - P < 0.01 versus the same tissues of rats infected with other doses of PRV