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Postępy Higieny i Medycyny Doświadczalnej
Volume 75 (2021): Issue 1 (January 2021)
Open Access
Application potential of modulation of cyclooxygenase-2 activity: a cognitive approach
Katarzyna Stachowicz
Katarzyna Stachowicz
| Dec 13, 2021
Postępy Higieny i Medycyny Doświadczalnej
Volume 75 (2021): Issue 1 (January 2021)
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Article Category:
Review
Published Online:
Dec 13, 2021
Page range:
837 - 846
Received:
Dec 18, 2020
Accepted:
Jun 07, 2021
DOI:
https://doi.org/10.2478/ahem-2021-0022
Keywords
COX-2
,
COX-2 inhibitors
,
cognition
,
Alzheimer disease
,
synaptic plasticity
© 2021 Katarzyna Stachowicz, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1
Schematic diagram of omega-6 and omega-3 PUFA pathways, taking into account diet and diseases in case of imbalance between omega-6 and omega-3.
Figure 2
Basic differences and similarities between COX isoenzymes (COX-1 and COX-2). Cellular and organ expression.
Figure 3
Participation of COX in prostanoid biosynthesis and transformations. PGG2 (prostaglandin G2) and PGH2 (prostaglandin H2) as products of COX activity.
Figure 4
Schematic diagram of pathways influencing COX/COX-2 expression in the pathomechanism of cognitive abnormalities/AD.