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Application potential of modulation of cyclooxygenase-2 activity: a cognitive approach

Katarzyna Stachowicz

Katarzyna Stachowicz

Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of SciencesKraków, Poland
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Stachowicz, Katarzyna
  
13 déc. 2021
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Catégorie d'article: Review
Publié en ligne: 13 déc. 2021
Pages: 837 - 846
Reçu: 18 déc. 2020
Accepté: 07 juin 2021
DOI: https://doi.org/10.2478/ahem-2021-0022
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© 2021 Katarzyna Stachowicz, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Schematic diagram of omega-6 and omega-3 PUFA pathways, taking into account diet and diseases in case of imbalance between omega-6 and omega-3.
Schematic diagram of omega-6 and omega-3 PUFA pathways, taking into account diet and diseases in case of imbalance between omega-6 and omega-3.

Figure 2

Basic differences and similarities between COX isoenzymes (COX-1 and COX-2). Cellular and organ expression.
Basic differences and similarities between COX isoenzymes (COX-1 and COX-2). Cellular and organ expression.

Figure 3

Participation of COX in prostanoid biosynthesis and transformations. PGG2 (prostaglandin G2) and PGH2 (prostaglandin H2) as products of COX activity.
Participation of COX in prostanoid biosynthesis and transformations. PGG2 (prostaglandin G2) and PGH2 (prostaglandin H2) as products of COX activity.

Figure 4

Schematic diagram of pathways influencing COX/COX-2 expression in the pathomechanism of cognitive abnormalities/AD.
Schematic diagram of pathways influencing COX/COX-2 expression in the pathomechanism of cognitive abnormalities/AD.
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Sujets de la revue:
Sciences de la vie, Biologie moléculaire, Microbiologie et virologie, Médecine, Sciences médicales de base, Immunologie
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