<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>3D printing has changed the paradigm of personalized medicine. Similarly to fingerprints, there are no two identical hearts; consequently, in cardiology, diagnosis and treatment, either medical, interventional or surgical, must be individualized according to the specific problem of a particular patient.</p>
</sec>
<sec>
<h3>The aim</h3> <p>of this proof-of-concept study was to analyze two measurement methods, the planimetric and the photogrammetric method, in the process of creating a 3D-printed model from cardiac computed tomography angiography images and to evaluate the accuracy of an aortic valve anatomical model.</p>
</sec>
<sec><h3>Material and methods</h3>
<p>Cardiac computed tomography images, obtained from 20 patients with severe aortic stenosis, underwent stereolithographic reconstruction using 3D Slicer to create digital 3D models of the aortic valves. Serial measurements of six key elements of the aortic valvular apparatus were measured on the 3D model and compared to the measurements taken on the 2D computed tomography images.</p>
</sec>
<sec><h3>Results</h3>
<p>The differences between the two measurement methods were sub-millimetric in case of the left ventricular outflow tract and the sinotubular junction, and 1.386 mm for the left sinus of Valsalva (p = 0.0412), 0.3476 mm for the right sinus of Valsalva (p = 0.1874), and 0.6905 mm for the non-coronary Valsalva sinuses (p = 0.1353). Sinus heights were also similar, with a difference of 0.0119 mm (p = 0.6521).</p>
</sec>
<sec><h3>Conclusion</h3>
<p>In this study, the results of digital photogrammetry were superimposable to those of computed tomography scan measurements. The accuracy of each 3D-printed model depends on geometric complexity, the level of training of the personnel, and on the resources of each 3D printing laboratory.</p>
</sec>
</abstract>

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology

Accuracy of 3D-Printed Models of Aortic Valves – a Comparative Analysis Between Planimetric and Photogrammetric Measurements

<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>Acrylic resins are the most frequently used materials for the bases of prostheses, and are also used in the re-optimization and the repair of prostheses.</p>
</sec>
<sec><h3>The aim</h3><p>of our study was to investigate whether direct contact with the resin causes decomposition of methyl methacrylate and formation of ketone bodies in the oral cavity.</p></sec>
<sec><h3>Material and methods</h3>
<p>The in vitro study included 12 samples of autopolymerized polymethyl methacrylate and 8 samples of thermopolymerized polymethyl methacrylate. Some of the resin samples were intentionally prepared incorrectly, with modified powder to liquid ratios or thermal regime, to be able to compare them with samples prepared according to the manufacturer’s instructions. Some of the samples were immersed in gastric juice or alcohol for 48 h at 37 °C in a thermostatic bath to simulate the environment and temperature of the oral cavity, while others were kept at room temperature. The Legal reaction was used to identify the presence of ketone bodies in the solutions.</p>
</sec>
<sec><h3>Results</h3>
<p>The samples that were prepared incorrectly and were kept at 37 °C were the most affected. The presence of ketone bodies was demonstrated by the formation of a precipitate on the bottom of the test tube and the color change of the solution. Samples that were kept at room temperature were less affected, both from a spectrophotometric and biochemical point of view.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>The quality of polymethyl methacrylate can be improved by respecting the manufacturer’s instructions and work protocols, and by avoiding substances that are considered aggressive, such as gastric juice, alcohol, and local factors in the oral cavity.</p>
</sec>
</abstract>

Denture Base Polymer Biodegradation: In Vitro Study

<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>The study was aimed to evaluate whether a mechanical biaxial tester can be used in a uniaxial mode to evaluate the mechanical properties of tendons.</p>
</sec>
<sec><h3>Materials and methods</h3>
<p>The study was carried out on specimens of porcine superficial digital flexor tendon (n = 9). The mechanical properties (elastic modulus, and stress at 15% strain) were measured two times consecutively in the uniaxial mode with the BioTester® 5000 (CellScale) equipment.</p>
</sec>
<sec><h3>Results</h3>
<p>Values of 0.313 ± 0.096 MPa for the elastic (Young’s) modulus and of 0.702 ± 0.174 MPa for the stress (at 15% strain) were measured, indicating that the porcine superficial digital flexor tendon is not a strong tendon.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>When suitable specimens cannot be obtained for a biaxial evaluation, tendons can be evaluated mechanically in the BioTester® 5000 employing the uniaxial mode.</p>
</sec>
</abstract>

“George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology

Biomechanical Uniaxial Analysis of Porcine Tendon in the CellScale BioTester® 5000

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Journal of Interdisciplinary Medicine

 The Journal of Interdisciplinary Medicine aims to publish top quality papers related to any fields of medicine that present an interdisciplinary dimension.  The journal will mainly focus on recent advances in the field of diagnosis and treatment of the most common situations encountered in the clinical or research practice. Interdisciplinary approaches will be extremely welcomed, presenting new advances in the approach of different pathologies from the perspective of various clinical fields.  The Journal of Interdisciplinary Medicine will publish high-quality basic and clinical research related to interdisciplinary medical fields, in a common approach that will integrate the clinical studies with the pre-clinical work dedicated to discovery of new mechanisms involved in the development and progression of a large spectrum of diseases.  The journal will try to provide the entire medical community with the perspective of the regional specifics in Central and Eastern European countries. The journal will primarily focus on publishing original research papers, but also other types of materials (such as review articles, case reports, state of the art papers, comments to editor, etc) will be extremely welcomed.  Rejection Rate:   30%   Archiving  Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.  Plagiarism Policy  The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 

Journal of Interdisciplinary Medicine

Volume 8 (2023): Issue 2 (June 2023)

Accuracy of 3D-Printed Models of Aortic Valves – a Comparative Analysis Between Planimetric and Photogrammetric Measurements

Denture Base Polymer Biodegradation: In Vitro Study

Biomechanical Uniaxial Analysis of Porcine Tendon in the CellScale BioTester® 5000

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