<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>3D printing has changed the paradigm of personalized medicine. Similarly to fingerprints, there are no two identical hearts; consequently, in cardiology, diagnosis and treatment, either medical, interventional or surgical, must be individualized according to the specific problem of a particular patient.</p>
</sec>
<sec>
<h3>The aim</h3> <p>of this proof-of-concept study was to analyze two measurement methods, the planimetric and the photogrammetric method, in the process of creating a 3D-printed model from cardiac computed tomography angiography images and to evaluate the accuracy of an aortic valve anatomical model.</p>
</sec>
<sec><h3>Material and methods</h3>
<p>Cardiac computed tomography images, obtained from 20 patients with severe aortic stenosis, underwent stereolithographic reconstruction using 3D Slicer to create digital 3D models of the aortic valves. Serial measurements of six key elements of the aortic valvular apparatus were measured on the 3D model and compared to the measurements taken on the 2D computed tomography images.</p>
</sec>
<sec><h3>Results</h3>
<p>The differences between the two measurement methods were sub-millimetric in case of the left ventricular outflow tract and the sinotubular junction, and 1.386 mm for the left sinus of Valsalva (p = 0.0412), 0.3476 mm for the right sinus of Valsalva (p = 0.1874), and 0.6905 mm for the non-coronary Valsalva sinuses (p = 0.1353). Sinus heights were also similar, with a difference of 0.0119 mm (p = 0.6521).</p>
</sec>
<sec><h3>Conclusion</h3>
<p>In this study, the results of digital photogrammetry were superimposable to those of computed tomography scan measurements. The accuracy of each 3D-printed model depends on geometric complexity, the level of training of the personnel, and on the resources of each 3D printing laboratory.</p>
</sec>
</abstract>

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology

Accuracy of 3D-Printed Models of Aortic Valves – a Comparative Analysis Between Planimetric and Photogrammetric Measurements

<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>Acrylic resins are the most frequently used materials for the bases of prostheses, and are also used in the re-optimization and the repair of prostheses.</p>
</sec>
<sec><h3>The aim</h3><p>of our study was to investigate whether direct contact with the resin causes decomposition of methyl methacrylate and formation of ketone bodies in the oral cavity.</p></sec>
<sec><h3>Material and methods</h3>
<p>The in vitro study included 12 samples of autopolymerized polymethyl methacrylate and 8 samples of thermopolymerized polymethyl methacrylate. Some of the resin samples were intentionally prepared incorrectly, with modified powder to liquid ratios or thermal regime, to be able to compare them with samples prepared according to the manufacturer’s instructions. Some of the samples were immersed in gastric juice or alcohol for 48 h at 37 °C in a thermostatic bath to simulate the environment and temperature of the oral cavity, while others were kept at room temperature. The Legal reaction was used to identify the presence of ketone bodies in the solutions.</p>
</sec>
<sec><h3>Results</h3>
<p>The samples that were prepared incorrectly and were kept at 37 °C were the most affected. The presence of ketone bodies was demonstrated by the formation of a precipitate on the bottom of the test tube and the color change of the solution. Samples that were kept at room temperature were less affected, both from a spectrophotometric and biochemical point of view.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>The quality of polymethyl methacrylate can be improved by respecting the manufacturer’s instructions and work protocols, and by avoiding substances that are considered aggressive, such as gastric juice, alcohol, and local factors in the oral cavity.</p>
</sec>
</abstract>

Denture Base Polymer Biodegradation: In Vitro Study

<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>The study was aimed to evaluate whether a mechanical biaxial tester can be used in a uniaxial mode to evaluate the mechanical properties of tendons.</p>
</sec>
<sec><h3>Materials and methods</h3>
<p>The study was carried out on specimens of porcine superficial digital flexor tendon (n = 9). The mechanical properties (elastic modulus, and stress at 15% strain) were measured two times consecutively in the uniaxial mode with the BioTester® 5000 (CellScale) equipment.</p>
</sec>
<sec><h3>Results</h3>
<p>Values of 0.313 ± 0.096 MPa for the elastic (Young’s) modulus and of 0.702 ± 0.174 MPa for the stress (at 15% strain) were measured, indicating that the porcine superficial digital flexor tendon is not a strong tendon.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>When suitable specimens cannot be obtained for a biaxial evaluation, tendons can be evaluated mechanically in the BioTester® 5000 employing the uniaxial mode.</p>
</sec>
</abstract>

“George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology

Biomechanical Uniaxial Analysis of Porcine Tendon in the CellScale BioTester® 5000

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Journal of Interdisciplinary Medicine

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Volume 8 (2023): Issue 2 (June 2023)

Accuracy of 3D-Printed Models of Aortic Valves – a Comparative Analysis Between Planimetric and Photogrammetric Measurements

Denture Base Polymer Biodegradation: In Vitro Study

Biomechanical Uniaxial Analysis of Porcine Tendon in the CellScale BioTester® 5000

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