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Detecting EGFR mutations in patients with non-small cell lung cancer

ZA Hammoudeh

ZA Hammoudeh

  • Department of Medical Genetics, Medical UniversitySofia, Bulgaria
  • Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Hammoudeh, ZA
, 
O Antonova

O Antonova

Department of Medical Genetics, Medical UniversitySofia, Bulgaria
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Antonova, O
, 
R Staneva

R Staneva

  • Department of Medical Genetics, Medical UniversitySofia, Bulgaria
  • Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Staneva, R
, 
D Nikolova

D Nikolova

Department of Medical Genetics, Medical UniversitySofia, Bulgaria
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Nikolova, D
, 
Y Kyuchukov

Y Kyuchukov

Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Kyuchukov, Y
, 
A Penev

A Penev

Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Penev, A
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T Mintchev

T Mintchev

Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Mintchev, T
, 
V Koleva

V Koleva

Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Koleva, V
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S Hadjidekova

S Hadjidekova

Department of Medical Genetics, Medical UniversitySofia, Bulgaria
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Hadjidekova, S
 oraz 
D Toncheva

D Toncheva

  • Department of Medical Genetics, Medical UniversitySofia, Bulgaria
  • Acibadem City Clinic Tokuda HospitalSofia, Bulgaria
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Toncheva, D
  
29 paź 2018
Detecting EGFR mutations in patients with non-small cell lung cancer's Cover Image
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Kategoria artykułu: Original Article
Data publikacji: 29 paź 2018
Zakres stron: 13 - 17
DOI: https://doi.org/10.2478/bjmg-2018-0013
Słowa kluczowe
© 2018 Hammoudeh ZA, Antonova O, Staneva R,, Nikolova D, Kyuchukov Y, Penev A, Mintchev T, Koleva V, Hadjidekova S, Toncheva D, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Plot shows EGFR positive samples for the exon 19 deletion; amplification of the internal control (Ctrl assay) with CT 26.45 and amplification for mutational assay (del assay) with CT 29.42. ΔCT = 2.97 (calculated by the formula ΔCT = mutation CT-control CT). The ΔCT cutoff value for this mutational assay was 9.06.
Plot shows EGFR positive samples for the exon 19 deletion; amplification of the internal control (Ctrl assay) with CT 26.45 and amplification for mutational assay (del assay) with CT 29.42. ΔCT = 2.97 (calculated by the formula ΔCT = mutation CT-control CT). The ΔCT cutoff value for this mutational assay was 9.06.

Types of the mutations detected_

Mutations DetectedPatients (n)%
Deletions in exon 193156.4
L858R2036.4
Insertions in exon 2023.6
Deletions in exon 19 and T790M11.8
Deletions in exon 19 and S768I11.8

Clinicopathological features of the 551 patients_

Clinicopathological FeaturesTotal Patients (n)Patients with Mutations or Wild-Type (n)p Value
MutationsWild-Type
Gender:
males40716391<0.0001
females14439105
Histology:
adenocarcinomas27641235
other types275142610.000232
Smoking history:
smokers33823315
non smokers213321810.002807
Język:
Angielski
Częstotliwość wydawania:
2 razy w roku
Dziedziny czasopisma:
Medycyna, Podstawowe nauki medyczne, Podstawowe nauki medyczne, inne
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