Strain No. | MIC of the drug used alone (µg/ml) | MIC of the drug used in combination (µg/ml) | FICI | Interaction | |
---|---|---|---|---|---|
Emodin | Caspofungin | Emodin + Caspofungin | |||
1 | 50 | 0.3 | 50 + 0.3 | 2 | Indifferent |
2 | 50 | 0.6 | 50 + 0.6 | 2 | Indifferent |
3 | 25 | 0.15 | 25 + 0.3 | 3 | Indifferent |
4 | 50 | 0.3 | 50 + 0.3 | 2 | Indifferent |
5 | 25 | 0.15 | 25 + 0.3 | 3 | Indifferent |
6 | 50 | 0.07 | 25 + 0.15 | 2.64 | Indifferent |
7 | 50 | 0.3 | 50 + 0.6 | 3 | Indifferent |
8 | 50 | 0.6 | 25 + 0.3 | 1 | Indifferent |
9 | 12.5 | 0.3 | 25 + 0.3 | 3 | Indifferent |
10 | 50 | 0.15 | 50 + 0.6 | 5 | Antagonism |
11 | 50 | 0.07 | 50 + 0.15 | 3 | Indifferent |
12 | 50 | 0.6 | 50 + 0.3 | 1.5 | Indifferent |
13 | 25 | 0.3 | 50 + 0.3 | 3 | Indifferent |
14 | 25 | 0.6 | 50 + 0.15 | 2.25 | Indifferent |
15 | 25 | 0.3 | 50 + 0.15 | 2.5 | Indifferent |
16 | 12.5 | 0.03 | 25 + 0.15 | 5 | Antagonism |
17 | 12.5 | 0.6 | 12.5 + 0.6 | 2 | Indifferent |
18 | 50 | 0.3 | 50 + 0.6 | 3 | Indifferent |
19 | 50 | 0.15 | 25 + 0.07 | 1 | Indifferent |
20 | 50 | 0.6 | 50 + 0.3 | 1.5 | Indifferent |
Strain No. | MIC of the drug used alone (µg/ml) | MIC of the drug used in combination (µg/ml) | FICI | Interaction | |
---|---|---|---|---|---|
Emodin | Caspofungin | Emodin + Caspofungin | |||
1 | 12.5 | 0.15 | 12.5 + 0.3 | 3 | Indifferent |
2 | 12.5 | 0.07 | 12.5 + 0.3 | 5.28 | Antagonism |
3 | 25 | 0.3 | 25 + 0.6 | 3 | Indifferent |
4 | 25 | 0.3 | 25 + 0.3 | 2 | Indifferent |
5 | 50 | 0.6 | 50 + 1.2 | 3 | Indifferent |
6 | 50 | 0.15 | 50 + 0.3 | 3 | Indifferent |
7 | 12.5 | 0.15 | 12.5 + 0.3 | 3 | Indifferent |
8 | 12.5 | 0.07 | 12.5 + 0.3 | 5.28 | Antagonism |
9 | 25 | 0.03 | 25 + 0.15 | 6 | Antagonism |
10 | 25 | 0.3 | 25 + 0.15 | 1.5 | Indifferent |
11 | 25 | 0.15 | 25 + 0.3 | 3 | Indifferent |
12 | 50 | 0.6 | 50 + 0.3 | 1.5 | Indifferent |
13 | 50 | 0.3 | 50 + 0.3 | 2 | Indifferent |
14 | 50 | 0.6 | 50 + 0.6 | 2 | Indifferent |
15 | 25 | 0.3 | 25 + 0.15 | 1.5 | Indifferent |
16 | 6.25 | 0.03 | 12.5 + 0.06 | 4 | Indifferent |
17 | 50 | 0.6 | 50 + 0.6 | 2 | Indifferent |
18 | 50 | 0.3 | 50 + 0.3 | 2 | Indifferent |
19 | 50 | 0.15 | 25 + 0.15 | 1.5 | Indifferent |
20 | 25 | 0.6 | 50 + 0.6 | 3 | Indifferent |
MIC (µg/ml) | ||
---|---|---|
Without sorbitol | With sorbitol | |
Emodin | 12.5 | 25 |
Caspofungin | 0.15 | 0.6 |
Amphotericin B | 1 | 1 |