HPeV type | Disease entities/symptoms |
HPeV-1 | diarrhoea [21, 23, 25, 37, 72, 76, 94] |
acute enteritis [5] |
necrotizing enterocolitis [12, 56] |
gastroenteritis [8, 21, 22, 31, 38, 40, 41, 49, 56, 70, 72, 74, 93, 95] |
upper respiratory tract infection [8, 38, 40, 41, 56, 93] |
bronchitis [93] |
pneumonia [98] |
AFP (acute flaccid paralysis) [34, 54, 65] |
Guillain-Barré syndrome [55] |
Reye syndrome [79] |
meningitis [34, 51] |
encephalitis [51, 74] |
encephalomyelitis [52] |
epilepsy [48] |
sepsis [8, 47] |
influenza-like illness [23] |
uveitis [28] |
otitis media [87] |
HUS (haemolytic uraemic syndrome) [69] |
myocarditis/cardiomyopathy [58, 96] |
HPeV-2 | diarrhoea [23, 37, 94] |
gastroenteritis [70] |
uveitis [28] |
AFP [65] |
HPeV-3 | fever [18] |
diarrhoea [21, 23, 35, 72] |
gastroenteritis [21, 22, 61, 62, 70, 72] |
hemorrhage-hepatitis syndrome [53] |
respiratory illness [19, 41, 93] |
AFP [65, 81] |
transient paralysis [45] |
facial palsy [61] |
meningitis [13, 35, 73, 93, 95] |
encephalitis [18, 24, 29, 59] |
sepsis [8, 14, 16, 18, 40, 46, 47, 53, 73, 84, 90, 92, 95] |
influenza-like illness [93] |
otitis media [14] |
conjunctivitis and uveitis [14, 28] |
rash [14, 48, 93] |
myositis/myalgia [60, 82, 93] |
hemophagocytic limphohistiocytosis (HLH) [39] |
sudden infant death syndrome (SIDS) [78] |
myocarditis [59] |
hypothyroidism [29] |
HPeV-4 | fever [11] |
diarrhoea [23, 37] |
gastroenteritis [21, 22, 23, 37, 38, 49, 70, 72, 74] |
sepsa [47] |
influenza-like illness [23] |
lymphadenitis [7, 21, 93] |
TORCH syndrome (a cluster of symptoms caused by congenital infection) [43] |
AFP [65] |
HPeV-5 | fever [18, 68] |
diarrhoea [21, 23, 37, 72] |
gastroenteritis [21, 22, 31, 61, 70, 72, 85] |
AFP [54] |
Reye syndrome [43] |
HPeV-6 | fever [30] |
diarrhoea [21, 23] |
gastroenteritis [5, 21, 22, 70, 93] |
upper respiratory tract infection [41] |
AFP [54, 93] |
Reye syndrome [93] |
Guillain-Barré syndrome [71] |
influenza-like illness [23] |
otitis media [30] |
rash [93] |
HPeV-7 | diarrhoea [37] |
AFP [54, 65] |
HPeV-8 | diarrhoea [37] |
gastroenteritis [22, 31, 70] |
encephalitis [61] |
HPeV-9 | diarrhoea [37] |
AFP [65] |
HPeV-10 | diarrhoea [61] |
gastroenteritis [2, 49, 61, 70, 72] |
influenza-like illness [23] |
HPeV-11 | gastroenteritis, diarrhoea [70, 72] |
HPeV-12 | gastroenteritis, diarrhoea [3] |
AFP [3, 65] |
HPeV-13 | gastroenteritis [2, 70] |
HPeV-14 | diarrhoea [21, 23, 25, 37] |
gastroenteritis [9, 21, 22, 70] |
fever [2] |
HPeV-15 | gastroenteritis, diarrhoea [2] |
HPeV-16 | enteritis [70] |
HPeV-17 | diarrhoea [37] |
enteritis [25] |
HPeV-18 | diarrhoea [37] |
HPeV-19 | – |