<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Acinetobacter baumannii is an aerobic gram-negative opportunistic bacterial pathogen, an emerging cause of healthcare-associated infections, associated with increased morbidity, mortality and healthcare costs. It has been widely found in the hospital environment, exhibiting high resistance to antimicrobials, affecting the spread of healthcare-associated infections and preventing effective infection control. The role of virulence factors in the pathogenesis of A. baumannii related human infections remains unclear. Therefore, molecular testing of pathogenic bacteria is an important tool for improving infection control measures against A. baumannii with combined resistance. The aim of this study was to analyse A. baumannii infection cases, antimicrobial resistance profiles and to characterise the genetic heterogeneity of isolates. In general, outbreaks occurring in hospitals are presumed to be clonal, with patient-to-patient transmission of essentially identical strains. Treatment decisions are based on a combination of in vitro susceptibility assays and empirical results based on patient outcomes.</p></abstract>

Acinetobacter baumannii is an aerobic gram-negative opportunistic bacterial pathogen, an emerging cause of healthcare-associated infections, associated with increased morbidity, mortality and healthcare costs. It has been widely found in the hospital environment, exhibiting high resistance to antimicrobials, affecting the spread of healthcare-associated infections and preventing effective infection control. The role of virulence factors in the pathogenesis of A. baumannii related human infections remains unclear. Therefore, molecular testing of pathogenic bacteria is an important tool for improving infection control measures against A. baumannii with combined resistance. The aim of this study was to analyse A. baumannii infection cases, antimicrobial resistance profiles and to characterise the genetic heterogeneity of isolates. In general, outbreaks occurring in hospitals are presumed to be clonal, with patient-to-patient transmission of essentially identical strains. Treatment decisions are based on a combination of in vitro susceptibility assays and empirical results based on patient outcomes.

Retrospective Study of Genetic Diversity of <italic>Acinetobacter Baumannii</italic>-Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Retrospective Study of Genetic Diversity of -Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Acinetobacter baumannii is an aerobic gram-negative opportunistic bacterial pathogen, an emerging cause of healthcare-associated infections, associated with...

Retrospective Study of Genetic Diversity of Acinetobacter Baumannii-Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Pubblicato online: 08 mag 2021

Pagine: 142 - 148

Ricevuto: 22 lug 2020

Accettato: 13 apr 2021

DOI: https://doi.org/10.2478/prolas-2021-0022

Parole chiave
A. baumannii, virulence factors, whole genome sequencing

© 2021 Māris Liepiņš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Retrospective Study of Genetic Diversity of Acinetobacter Baumannii-Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Pubblicato online: 08 mag 2021

Pagine: 142 - 148

Ricevuto: 22 lug 2020

Accettato: 13 apr 2021

DOI: https://doi.org/10.2478/prolas-2021-0022

Parole chiaveA. baumannii, virulence factors, whole genome sequencing

© 2021 Māris Liepiņš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
A. baumannii, virulence factors, whole genome sequencing