<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Acinetobacter baumannii is an aerobic gram-negative opportunistic bacterial pathogen, an emerging cause of healthcare-associated infections, associated with increased morbidity, mortality and healthcare costs. It has been widely found in the hospital environment, exhibiting high resistance to antimicrobials, affecting the spread of healthcare-associated infections and preventing effective infection control. The role of virulence factors in the pathogenesis of A. baumannii related human infections remains unclear. Therefore, molecular testing of pathogenic bacteria is an important tool for improving infection control measures against A. baumannii with combined resistance. The aim of this study was to analyse A. baumannii infection cases, antimicrobial resistance profiles and to characterise the genetic heterogeneity of isolates. In general, outbreaks occurring in hospitals are presumed to be clonal, with patient-to-patient transmission of essentially identical strains. Treatment decisions are based on a combination of in vitro susceptibility assays and empirical results based on patient outcomes.</p></abstract>

Acinetobacter baumannii is an aerobic gram-negative opportunistic bacterial pathogen, an emerging cause of healthcare-associated infections, associated with increased morbidity, mortality and healthcare costs. It has been widely found in the hospital environment, exhibiting high resistance to antimicrobials, affecting the spread of healthcare-associated infections and preventing effective infection control. The role of virulence factors in the pathogenesis of A. baumannii related human infections remains unclear. Therefore, molecular testing of pathogenic bacteria is an important tool for improving infection control measures against A. baumannii with combined resistance. The aim of this study was to analyse A. baumannii infection cases, antimicrobial resistance profiles and to characterise the genetic heterogeneity of isolates. In general, outbreaks occurring in hospitals are presumed to be clonal, with patient-to-patient transmission of essentially identical strains. Treatment decisions are based on a combination of in vitro susceptibility assays and empirical results based on patient outcomes.

Retrospective Study of Genetic Diversity of <italic>Acinetobacter Baumannii</italic>-Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Retrospective Study of Genetic Diversity of -Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Acinetobacter baumannii is an aerobic gram-negative opportunistic bacterial pathogen, an emerging cause of healthcare-associated infections, associated with...

Retrospective Study of Genetic Diversity of Acinetobacter Baumannii-Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Published Online: May 08, 2021

Page range: 142 - 148

Received: Jul 22, 2020

Accepted: Apr 13, 2021

DOI: https://doi.org/10.2478/prolas-2021-0022

Keywords
A. baumannii, virulence factors, whole genome sequencing

© 2021 Māris Liepiņš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Retrospective Study of Genetic Diversity of Acinetobacter Baumannii-Resistant Strains Isolated from Patients in Rīga East University Hospital in Latvia

Published Online: May 08, 2021

Page range: 142 - 148

Received: Jul 22, 2020

Accepted: Apr 13, 2021

DOI: https://doi.org/10.2478/prolas-2021-0022

KeywordsA. baumannii, virulence factors, whole genome sequencing

© 2021 Māris Liepiņš et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
A. baumannii, virulence factors, whole genome sequencing