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Journal of Veterinary Research
Volume 64 (2020): Numero 1 (March 2020)
Accesso libero
Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway
Yi-Ran Luo
Yi-Ran Luo
,
Shu-Ting Zhou
Shu-Ting Zhou
,
Liang Yang
Liang Yang
,
Yuan-Ping Liu
Yuan-Ping Liu
,
Sheng-Yao Jiang
Sheng-Yao Jiang
,
Yeliboli Dawuli
Yeliboli Dawuli
,
Yi-Xuan Hou
Yi-Xuan Hou
,
Tian-Xing Zhou
Tian-Xing Zhou
e
Zhi-Biao Yang
Zhi-Biao Yang
| 24 mar 2020
Journal of Veterinary Research
Volume 64 (2020): Numero 1 (March 2020)
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CONDIVIDI
Pubblicato online:
24 mar 2020
Pagine:
25 - 32
Ricevuto:
07 giu 2019
Accettato:
09 mar 2020
DOI:
https://doi.org/10.2478/jvetres-2020-0024
Parole chiave
porcine epidemic diarrhoea virus
,
cell cycle
,
virus proliferation
,
DNA damage
,
signalling pathways
© 2020 Y.R. Luo et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fig. 1
A – analysis workflow for flow cytometry data; B – changes in cell cycle of Vero cells infected with PEDV between 0 h and 32 h after infection
Fig. 2
changes in proportion of cells in the G1/G0 phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Fig. 3
Changes in proportion of cells in the S phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Fig. 4
Changes in proportion of cells in the G2/M phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Fig. 5
Changes over time in Cyclin B1, D1, and E1 in Vero cells infected with PEDV (M – control; I – PEDV infected cells)
Fig. 6
Changes over time in Chk.2, H2A.X, p53, and PEDV-N in Vero cells infected with PEDV (M – control, I – PEDV infected cells)
Fig. 7
Cell cycle data of control or PEDV-infected Vero cells treated by DMSO, ATM inhibitor, or/ and Chk.2 inhibitor
Fig. 8
Virus proliferation evaluated by real-time PCR of control or PEDV infected Vero cells treated by DMSO, ATM inhibitor or Chk.2 inhibitor