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Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway

Yi-Ran Luo

Yi-Ran Luo

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Luo, Yi-Ran
, 
Shu-Ting Zhou

Shu-Ting Zhou

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Zhou, Shu-Ting
, 
Liang Yang

Liang Yang

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Yang, Liang
, 
Yuan-Ping Liu

Yuan-Ping Liu

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Liu, Yuan-Ping
, 
Sheng-Yao Jiang

Sheng-Yao Jiang

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Jiang, Sheng-Yao
, 
Yeliboli Dawuli

Yeliboli Dawuli

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Dawuli, Yeliboli
, 
Yi-Xuan Hou

Yi-Xuan Hou

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Hou, Yi-Xuan
, 
Tian-Xing Zhou

Tian-Xing Zhou

College of Biological Science and Technology, Beijing Forestry UniversityBeijing, China
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Zhou, Tian-Xing
 und 
Zhi-Biao Yang

Zhi-Biao Yang

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China
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Yang, Zhi-Biao
  
24. März 2020
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Online veröffentlicht: 24. März 2020
Seitenbereich: 25 - 32
Eingereicht: 07. Juni 2019
Akzeptiert: 09. März 2020
DOI: https://doi.org/10.2478/jvetres-2020-0024
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© 2020 Y.R. Luo et al. published by Sciendo
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Fig. 1

A – analysis workflow for flow cytometry data; B – changes in cell cycle of Vero cells infected with PEDV between 0 h and 32 h after infection
A – analysis workflow for flow cytometry data; B – changes in cell cycle of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 2

changes in proportion of cells in the G1/G0 phase of Vero cells infected with PEDV between 0 h and 32 h after infection
changes in proportion of cells in the G1/G0 phase of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 3

Changes in proportion of cells in the S phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Changes in proportion of cells in the S phase of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 4

Changes in proportion of cells in the G2/M phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Changes in proportion of cells in the G2/M phase of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 5

Changes over time in Cyclin B1, D1, and E1 in Vero cells infected with PEDV (M – control; I – PEDV infected cells)
Changes over time in Cyclin B1, D1, and E1 in Vero cells infected with PEDV (M – control; I – PEDV infected cells)

Fig. 6

Changes over time in Chk.2, H2A.X, p53, and PEDV-N in Vero cells infected with PEDV (M – control, I – PEDV infected cells)
Changes over time in Chk.2, H2A.X, p53, and PEDV-N in Vero cells infected with PEDV (M – control, I – PEDV infected cells)

Fig. 7

Cell cycle data of control or PEDV-infected Vero cells treated by DMSO, ATM inhibitor, or/ and Chk.2 inhibitor
Cell cycle data of control or PEDV-infected Vero cells treated by DMSO, ATM inhibitor, or/ and Chk.2 inhibitor

Fig. 8

Virus proliferation evaluated by real-time PCR of control or PEDV infected Vero cells treated by DMSO, ATM inhibitor or Chk.2 inhibitor
Virus proliferation evaluated by real-time PCR of control or PEDV infected Vero cells treated by DMSO, ATM inhibitor or Chk.2 inhibitor
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