Accès libre

DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

Jana Korcová

Jana Korcová

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
Recherchez cet auteur sur
Sciendo|Google Scholar
Korcová, Jana
, 
Mária Húserková

Mária Húserková

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
Recherchez cet auteur sur
Sciendo|Google Scholar
Húserková, Mária
, 
Lucia Lintnerová

Lucia Lintnerová

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
Recherchez cet auteur sur
Sciendo|Google Scholar
Lintnerová, Lucia
 et 
Jindra Valentová

Jindra Valentová

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
Recherchez cet auteur sur
Sciendo|Google Scholar
Valentová, Jindra
  
28 mars 2024
DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids's Cover Image
À propos de cet article
Article précédent
Article suivant
Citez
Télécharger la couverture
Catégorie d'article: Short communication
Publié en ligne: 28 mars 2024
Pages: 48 - 51
Reçu: 09 oct. 2023
Accepté: 15 févr. 2024
DOI: https://doi.org/10.2478/afpuc-2024-0003
Mots clés
© 2024 Jana Korcová et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
undefined

Fig. 1.

DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 2.

DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 3.

DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 4.

DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Figure 5.

Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05
Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05

j_afpuc-2024-0003_tab_001

Wavelenght Resorufin ɛRED Resazurin ɛOX
570 nm 155,677 80,586
600 nm 14,652 117,216
Langue:
Anglais
Périodicité:
2 fois par an
Sujets de la revue:
Pharmacie, Pharmacie, autres
RSS Feed de la revue