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DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

Jana Korcová

Jana Korcová

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
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Korcová, Jana
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Mária Húserková

Mária Húserková

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
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Húserková, Mária
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Lucia Lintnerová

Lucia Lintnerová

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
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Lintnerová, Lucia
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Jindra Valentová

Jindra Valentová

Comenius University, Faculty of Pharmacy, Department of Chemical Theory of DrugsBratislava, Slovakia
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Valentová, Jindra
  
28 mar 2024
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Categoría del artículo: Short communication
Publicado en línea: 28 mar 2024
Páginas: 48 - 51
Recibido: 09 oct 2023
Aceptado: 15 feb 2024
DOI: https://doi.org/10.2478/afpuc-2024-0003
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© 2024 Jana Korcová et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Fig. 1.

DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 2.

DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 3.

DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 4.

DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Figure 5.

Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05
Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05

j_afpuc-2024-0003_tab_001

Wavelenght Resorufin ɛRED Resazurin ɛOX
570 nm 155,677 80,586
600 nm 14,652 117,216
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