Login
Register
Reset Password
Publish & Distribute
Publishing Solutions
Distribution Solutions
Subjects
Architecture and Design
Arts
Business and Economics
Chemistry
Classical and Ancient Near Eastern Studies
Computer Sciences
Cultural Studies
Engineering
General Interest
Geosciences
History
Industrial Chemistry
Jewish Studies
Law
Library and Information Science, Book Studies
Life Sciences
Linguistics and Semiotics
Literary Studies
Materials Sciences
Mathematics
Medicine
Music
Pharmacy
Philosophy
Physics
Social Sciences
Sports and Recreation
Theology and Religion
Publications
Journals
Books
Proceedings
Publishers
Blog
Contact
Search
EUR
USD
GBP
English
English
Deutsch
Polski
Español
Français
Italiano
Cart
Home
Journals
European Pharmaceutical Journal
Volume 70 (2023): Issue s2 (December 2023)
Open Access
DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids
Jana Korcová
Jana Korcová
,
Mária Húserková
Mária Húserková
,
Lucia Lintnerová
Lucia Lintnerová
and
Jindra Valentová
Jindra Valentová
| Mar 28, 2024
European Pharmaceutical Journal
Volume 70 (2023): Issue s2 (December 2023)
About this article
Previous Article
Next Article
Abstract
Article
Figures & Tables
References
Authors
Articles in this Issue
Preview
PDF
Cite
Share
Article Category:
Short communication
Published Online:
Mar 28, 2024
Page range:
48 - 51
Received:
Oct 09, 2023
Accepted:
Feb 15, 2024
DOI:
https://doi.org/10.2478/afpuc-2024-0003
Keywords
copper(II) complexes
,
anticancer drugs
,
DNA cleavage activity
,
cytotoxicity
© 2024 Jana Korcová et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1.
DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
Fig. 2.
DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
Fig. 3.
DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
Fig. 4.
DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
Figure 5.
Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05
j.afpuc-2024-0003.tab.001
Wavelenght
Resorufin
ɛ
RED
Resazurin
ɛ
OX
570 nm
155,677
80,586
600 nm
14,652
117,216