<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Metal complexes, which, under physiologic conditions, show redox properties and are able to bind to DNA, are great tools to cleave the DNA chain. This aspect is of great importance for their use as antineoplastic drugs. We synthesized ligands derived from short-chain amino acids and from salicylaldehyde. The prepared ligands of the type of reduced Schiff bases were subsequently used for the preparation of copper(II) complexes. The aim of the study was in vitro testing of copper(II) complexes, where it was confirmed that they are capable of cleaving DNA. Their cytotoxic activity was also confirmed by the resazurin redox method on Saccharomyces cerevisiae based on preserved healthy mitochondrial function.</p>
</abstract>

Metal complexes, which, under physiologic conditions, show redox properties and are able to bind to DNA, are great tools to cleave the DNA chain. This aspect is of great importance for their use as antineoplastic drugs. We synthesized ligands derived from short-chain amino acids and from salicylaldehyde. The prepared ligands of the type of reduced Schiff bases were subsequently used for the preparation of copper(II) complexes. The aim of the study was in vitro testing of copper(II) complexes, where it was confirmed that they are capable of cleaving DNA. Their cytotoxic activity was also confirmed by the resazurin redox method on Saccharomyces cerevisiae based on preserved healthy mitochondrial function.

DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

Faculty of Pharmacy, Department of Chemical Theory of Drugs

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Metal complexes, which, under physiologic conditions, show redox properties and are able to bind to DNA, are great tools to cleave the DNA chain. This aspect...

DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

Article Category: Short communication

Publié en ligne: 28 mars 2024

Pages: 48 - 51

Reçu: 09 oct. 2023

Accepté: 15 févr. 2024

DOI: https://doi.org/10.2478/afpuc-2024-0003

Mots clés
copper(II) complexes, anticancer drugs, DNA cleavage activity, cytotoxicity

© 2024 Jana Korcová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

Article Category: Short communication

Publié en ligne: 28 mars 2024

Pages: 48 - 51

Reçu: 09 oct. 2023

Accepté: 15 févr. 2024

DOI: https://doi.org/10.2478/afpuc-2024-0003

Mots cléscopper(II) complexes, anticancer drugs, DNA cleavage activity, cytotoxicity

© 2024 Jana Korcová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
copper(II) complexes, anticancer drugs, DNA cleavage activity, cytotoxicity