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Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma

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09. Juli 2016

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Mitochondrial tRNA mutations with standard nt numbering, arrows indicate the locations of mt-tRNA variants.
Mitochondrial tRNA mutations with standard nt numbering, arrows indicate the locations of mt-tRNA variants.
Phylogenetic conservation analysis of the A12308G variant (the arrow shows position 44 that corresponds to the A12308G variant).
Phylogenetic conservation analysis of the A12308G variant (the arrow shows position 44 that corresponds to the A12308G variant).

Molecular characterization of mt-tRNA variants for thyroid cancer_

tRNAtRNAAsptRNAArgtRNALeu(CUN)tRNAIletRNAAla
Nt changesG7521AT10411CT10463CA12308GG4292CC4312TT5655C
Number of nts in tRNA47674434541
Positionacceptor armacceptor armacceptor armvariable loopanticodon armT armacceptor arm
Homoplasmy/heteroplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmy
CI (%)13.521.194.293.310.019.071.2
G (wild type)(kcal/mol)‒10.59‒10.58‒10.86‒16.01‒8.98‒8.98‒18.47
G (mutant)(kcal/mol)‒11.11‒10.13‒10.13‒15.88‒9.06‒9.12‒18.81
Sprache:
Englisch
Zeitrahmen der Veröffentlichung:
2 Hefte pro Jahr
Fachgebiete der Zeitschrift:
Medizin, Vorklinische Medizin, Grundlagenmedizin, Vorklinische Medizin, Grundlagenmedizin, andere