Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma
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09 jul 2016
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Categoría del artículo: Original Article
Publicado en línea: 09 jul 2016
Páginas: 59 - 64
DOI: https://doi.org/10.1515/bjmg-2015-0090
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© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Molecular characterization of mt-tRNA variants for thyroid cancer_
| tRNA | tRNAAsp | tRNAArg | tRNALeu(CUN) | tRNAIle | tRNAAla | ||
|---|---|---|---|---|---|---|---|
| Nt changes | G7521A | T10411C | T10463C | A12308G | G4292C | C4312T | T5655C |
| Number of nts in tRNA | 4 | 7 | 67 | 44 | 34 | 54 | 1 |
| Position | acceptor arm | acceptor arm | acceptor arm | variable loop | anticodon arm | T arm | acceptor arm |
| Homoplasmy/heteroplasmy | homoplasmy | homoplasmy | homoplasmy | homoplasmy | homoplasmy | homoplasmy | homoplasmy |
| CI (%) | 13.5 | 21.1 | 94.2 | 93.3 | 10.0 | 19.0 | 71.2 |
| G (wild type)(kcal/mol) | ‒10.59 | ‒10.58 | ‒10.86 | ‒16.01 | ‒8.98 | ‒8.98 | ‒18.47 |
| G (mutant)(kcal/mol) | ‒11.11 | ‒10.13 | ‒10.13 | ‒15.88 | ‒9.06 | ‒9.12 | ‒18.81 |