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Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma

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09 lug 2016

Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma's Cover Image

Balkan Journal of Medical Genetics

Volume 18 (2015): Numero 2 (Dicembre 2015)

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Categoria dell'articolo: Original Article

Pubblicato online: 09 lug 2016

Pagine: 59 - 64

DOI: https://doi.org/10.1515/bjmg-2015-0090

Parole chiave
Association, Mitochondrial DNA (mtDNA), Thyroid cancer, Mitochondrial transfer RNA (mt-tRNA), Variants

© 2016 Walter de Gruyter GmbH, Berlin/Boston

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Mitochondrial tRNA mutations with standard nt numbering, arrows indicate the locations of mt-tRNA variants.

Phylogenetic conservation analysis of the A12308G variant (the arrow shows position 44 that corresponds to the A12308G variant).

Molecular characterization of mt-tRNA variants for thyroid cancer_

tRNA	tRNA^Asp	tRNA^Arg		tRNA^Leu(CUN)	tRNA^Ile		tRNA^Ala
Nt changes	G7521A	T10411C	T10463C	A12308G	G4292C	C4312T	T5655C
Number of nts in tRNA	4	7	67	44	34	54	1
Position	acceptor arm	acceptor arm	acceptor arm	variable loop	anticodon arm	T arm	acceptor arm
Homoplasmy/heteroplasmy	homoplasmy	homoplasmy	homoplasmy	homoplasmy	homoplasmy	homoplasmy	homoplasmy
CI (%)	13.5	21.1	94.2	93.3	10.0	19.0	71.2
G (wild type)(kcal/mol)	‒10.59	‒10.58	‒10.86	‒16.01	‒8.98	‒8.98	‒18.47
G (mutant)(kcal/mol)	‒11.11	‒10.13	‒10.13	‒15.88	‒9.06	‒9.12	‒18.81

Lingua:: Inglese

Frequenza di pubblicazione:: 2 volte all'anno
Argomenti della rivista:: Medicina, Scienze medicali di base, Scienze medicali di base, altro

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