<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) being the most prevalent globally. Even though the diseases increase in prevalence, the exact underlying mechanisms have still not been fully understood. Despite their differences in nature, pathophysiologies, and clinical phenotypes, a growing body of evidence indicates that the presence of lung microbiota can shape the pathogenic processes underlying chronic inflammation, typically observed in the course of the diseases. Therefore, the characterization of the lung microbiota may shed new light on the pathogenesis of these diseases. Specifically, in chronic respiratory tract diseases, the human microbiota may contribute to the disease’s development and severity. The present review explores the role of the microbiota in the area of chronic pulmonary diseases, especially COPD, asthma, and CF.</p></abstract>

Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) being the most prevalent globally. Even though the diseases increase in prevalence, the exact underlying mechanisms have still not been fully understood. Despite their differences in nature, pathophysiologies, and clinical phenotypes, a growing body of evidence indicates that the presence of lung microbiota can shape the pathogenic processes underlying chronic inflammation, typically observed in the course of the diseases. Therefore, the characterization of the lung microbiota may shed new light on the pathogenesis of these diseases. Specifically, in chronic respiratory tract diseases, the human microbiota may contribute to the disease’s development and severity. The present review explores the role of the microbiota in the area of chronic pulmonary diseases, especially COPD, asthma, and CF.

Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF)...

Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases

Article Category: minireview

Published Online: Mar 19, 2021

Page range: 25 - 32

Received: Dec 07, 2020

Accepted: Feb 18, 2021

DOI: https://doi.org/10.33073/pjm-2021-013

Keywords
microbiota, asthma, COPD, cystic fibrosis, lungs

© 2021 Agnieszka Magryś et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases

Article Category: minireview

Published Online: Mar 19, 2021

Page range: 25 - 32

Received: Dec 07, 2020

Accepted: Feb 18, 2021

DOI: https://doi.org/10.33073/pjm-2021-013

Keywordsmicrobiota, asthma, COPD, cystic fibrosis, lungs

© 2021 Agnieszka Magryś et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Keywords
microbiota, asthma, COPD, cystic fibrosis, lungs