<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Hepatitis B infection is still a global concern progressing as acute-chronic hepatitis, severe liver failure, and death. The infection is most widely transmitted from the infected mother to a child, with infected blood and body fluids. Pregnant women, adolescents, and all adults at high risk of chronic infection are recommended to be screened for hepatitis B infection. The initial analysis includes serological tests that allow differentiation of acute and chronic hepatitis. Molecular assays performed provide detection and quantification of viral DNA, genotyping, drug resistance, and precore/core mutation analysis to confirm infection and monitor disease progression in chronic hepatitis B patients. All patients with chronic hepatitis B should be treated with antiviral medications and regularly monitored for efficient treatment. The current treatment is based on nucleos(t)ide analogs and pegylated interferons that save lives by decreasing liver cancer death, liver transplant, slow or reverse the progression of liver disease as well as the virus infectivity.</p></abstract>

Hepatitis B infection is still a global concern progressing as acute-chronic hepatitis, severe liver failure, and death. The infection is most widely transmitted from the infected mother to a child, with infected blood and body fluids. Pregnant women, adolescents, and all adults at high risk of chronic infection are recommended to be screened for hepatitis B infection. The initial analysis includes serological tests that allow differentiation of acute and chronic hepatitis. Molecular assays performed provide detection and quantification of viral DNA, genotyping, drug resistance, and precore/core mutation analysis to confirm infection and monitor disease progression in chronic hepatitis B patients. All patients with chronic hepatitis B should be treated with antiviral medications and regularly monitored for efficient treatment. The current treatment is based on nucleos(t)ide analogs and pegylated interferons that save lives by decreasing liver cancer death, liver transplant, slow or reverse the progression of liver disease as well as the virus infectivity.

Hepatitis B Virus: From Diagnosis to Treatment

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Hepatitis B Virus: From Diagnosis to Treatment"}

Hepatitis B infection is still a global concern progressing as acute-chronic hepatitis, severe liver failure, and death. The infection is most widely...

Hepatitis B Virus: From Diagnosis to Treatment

Article Category: mini-review

Published Online: Dec 27, 2020

Page range: 391 - 399

Received: Jul 21, 2020

Accepted: Sep 24, 2020

DOI: https://doi.org/10.33073/pjm-2020-044

Keywords
hepatitis B virus (HBV), serology, nucleic acid testing, antiviral treatment

© 2020 Meryem Guvenir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Fig. 2.

Hepatitis B Virus: From Diagnosis to Treatment

Article Category: mini-review

Published Online: Dec 27, 2020

Page range: 391 - 399

Received: Jul 21, 2020

Accepted: Sep 24, 2020

DOI: https://doi.org/10.33073/pjm-2020-044

Keywordshepatitis B virus (HBV), serology, nucleic acid testing, antiviral treatment

© 2020 Meryem Guvenir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Fig. 2.

Keywords
hepatitis B virus (HBV), serology, nucleic acid testing, antiviral treatment