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What proteins and albumins in bronchoalveolar lavage fluid and serum could tell us in COVID-19 and influenza acute respiratory distress syndrome on mechanical ventilation patient - A prospective double center study

Anita Djurdjevic Svraka

Anita Djurdjevic Svraka

Faculty of Medicine, University of Banja LukaBanjaluka, Bosnia and Herzegovina
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Svraka, Anita Djurdjevic
, 
Dragan Svraka

Dragan Svraka

  • Faculty of Medicine, University of Banja LukaBanjaluka, Bosnia and Herzegovina
  • University Clinical Centre of the Republic of Srpska
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Svraka, Dragan
, 
Bosa Mrjanic Azaric

Bosa Mrjanic Azaric

Faculty of Medicine, University of Banja LukaBanjaluka, Bosnia and Herzegovina
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Azaric, Bosa Mrjanic
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Jovana Malic

Jovana Malic

  • Faculty of Medicine, University of Banja LukaBanjaluka, Bosnia and Herzegovina
  • University Clinical Centre of the Republic of Srpska
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Malic, Jovana
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Goran Baric

Goran Baric

  • Faculty of Medicine, University of Banja LukaBanjaluka, Bosnia and Herzegovina
  • University Clinical Centre of the Republic of Srpska
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Baric, Goran
 and 
Pedja Kovacevic

Pedja Kovacevic

  • Faculty of Medicine, University of Banja LukaBanjaluka, Bosnia and Herzegovina
  • University Clinical Centre of the Republic of Srpska
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Kovacevic, Pedja
  
Jan 31, 2025
What proteins and albumins in bronchoalveolar lavage fluid and serum could tell us in COVID-19 and influenza acute respiratory distress syndrome on mechanical ventilation patient - A prospective double center study's Cover Image
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Article Category: Research Article
Published Online: Jan 31, 2025
Page range: 64 - 69
Received: Mar 08, 2024
Accepted: Jan 08, 2025
DOI: https://doi.org/10.2478/jccm-2025-0005
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© 2025 Anita Djurdjevic Svraka et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Fig. 1.

Mechanical ventilation days of ARDS (median, IQR) divided by groups
Mechanical ventilation days of ARDS (median, IQR) divided by groups

Fig 2.

Comparison of ARDS patient outcomes between COVID-19 and H1N1 concerning mechanical ventilation duration.
Comparison of ARDS patient outcomes between COVID-19 and H1N1 concerning mechanical ventilation duration.

Proteins and albumins values between the patient group and outcomes

COVID-19 group (mean±SD) H1N1 group (mean±SD) Control group (mean±SD) p* Survivors (mean±SD) Deceased (mean±SD) p**
BAL albumin (g/L) 1.63±1.35 1.55±1.46 0.07±0.07 <0.001 0.58±1.11 1.71±1.34 <0.001
BAL total protein (g/L) 1.53±0.71 1.47±0.71 0.43±0.35 <0.001 0.85±0.71 1.52±0.72 <0.001
Serum albumin (g/L) 28.73±4.97 31.93±4.85 38.43±4.03 <0.001 36.09±5.17 28.61±4.89 <0.001

Demographic variables, days of invasive mechanical ventilation and outcome between two groups of ARDS patients

COVID-19 group H1N1 group p* Survivors Deceased p**
Patients (n) 30 14 NA 13 (29.5%) 31(70.5%) NA
Age (median, IQR) 72.5 (35–83) 62 (34–69) <0.01 60 (35–70) 72 (34–83) <0.01
Male (n,%) 17 (56.7%) 7(50%) 0.7 9 (37.5%) 15 (62.5%) 0.24
COPD (n,%) 3 (10%) 3 (21.4%) 0.43 1 (16.7%) 5 (83.3%) 0.57
CV diseases (n,%) 18 (60%) 6 (42.9%) 0.33 6 (25%) 18 (75%) 0.51
Diabetes (n,%) 6 (20%) 2 (14%) 0.71 1 (12.5%) 7 (87.5%) 0.35
CMV days (median, IQR) 13 (1–31) 14 (1–34) 0.27 13 (1–39) 13 (1–39) 0.5
Survivors (n,&) 5 (16.7%) 8 (57.1%) <0.01 NA NA NA
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