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What proteins and albumins in bronchoalveolar lavage fluid and serum could tell us in COVID-19 and influenza acute respiratory distress syndrome on mechanical ventilation patient - A prospective double center study

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31 ene 2025

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Fig. 1.

Mechanical ventilation days of ARDS (median, IQR) divided by groups
Mechanical ventilation days of ARDS (median, IQR) divided by groups

Fig 2.

Comparison of ARDS patient outcomes between COVID-19 and H1N1 concerning mechanical ventilation duration.
Comparison of ARDS patient outcomes between COVID-19 and H1N1 concerning mechanical ventilation duration.

Proteins and albumins values between the patient group and outcomes

COVID-19 group (mean±SD) H1N1 group (mean±SD) Control group (mean±SD) p* Survivors (mean±SD) Deceased (mean±SD) p**
BAL albumin (g/L) 1.63±1.35 1.55±1.46 0.07±0.07 <0.001 0.58±1.11 1.71±1.34 <0.001
BAL total protein (g/L) 1.53±0.71 1.47±0.71 0.43±0.35 <0.001 0.85±0.71 1.52±0.72 <0.001
Serum albumin (g/L) 28.73±4.97 31.93±4.85 38.43±4.03 <0.001 36.09±5.17 28.61±4.89 <0.001

Demographic variables, days of invasive mechanical ventilation and outcome between two groups of ARDS patients

COVID-19 group H1N1 group p* Survivors Deceased p**
Patients (n) 30 14 NA 13 (29.5%) 31(70.5%) NA
Age (median, IQR) 72.5 (35–83) 62 (34–69) <0.01 60 (35–70) 72 (34–83) <0.01
Male (n,%) 17 (56.7%) 7(50%) 0.7 9 (37.5%) 15 (62.5%) 0.24
COPD (n,%) 3 (10%) 3 (21.4%) 0.43 1 (16.7%) 5 (83.3%) 0.57
CV diseases (n,%) 18 (60%) 6 (42.9%) 0.33 6 (25%) 18 (75%) 0.51
Diabetes (n,%) 6 (20%) 2 (14%) 0.71 1 (12.5%) 7 (87.5%) 0.35
CMV days (median, IQR) 13 (1–31) 14 (1–34) 0.27 13 (1–39) 13 (1–39) 0.5
Survivors (n,&) 5 (16.7%) 8 (57.1%) <0.01 NA NA NA