The Correlation of Hemostatic Parameters with the Development of Early Sepsis-Associated Encephalopathy. A Retrospective Observational Study
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Oct 31, 2024
About this article
Article Category: Research Article
Published Online: Oct 31, 2024
Page range: 329 - 336
Received: Feb 28, 2024
Accepted: Sep 28, 2024
DOI: https://doi.org/10.2478/jccm-2024-0040
Keywords
© 2024 Florin Scarlatescu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Fig. 1.
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Fig. 3.
Multivariate logistic regression model using age and complete blood count parameters_
| Leucocyte count | 1.000 | 1.000; 1.000 | 0.403 |
| Platelet count | 1.003 | 1.001; 1.006 | 0.004 |
| Age | 1.003 | 0.987; 1.020 | 0.710 |
Demographic data and complete blood count parameters in patients with and without sepsis-associated encephalopathy (SAE)_
| Age (years) | 73 (18) | 70 (16) | 0.088 | |
| Male sex | 94 (51.08%) | 52 (54.16%) | 0.624 | |
| Leucocyte count (per μL) | 14100 (10960) | 10265 (10882) | 4000–9000 | 0.003 |
| Hemoglobin (g/dL) | 10.1 (3.9) | 9.8 (3.8) | 11.5–17 | 0.276 |
| Platelet count (per μL) | 200000 (166500) | 128500 (149500) | 150000–400000 | <0.001 |
Multivariate logistic regression model using fibrinogen levels and platelet contribution to clot strength_
| Fibrinogen level | 1.000 | 0.997; 1.002 | 0.403 |
| Platelet component | 1.007 | 1.001; 1.013 | 0.02 |
Hemostatic tests in patients with and without sepsis-associated encephalopathy (SAE)_
| PT (s) | 15.95 (3.8) | 17 (5.2) | 10.4–14.3 | 0.440 |
| Fibrinogen (mg/dL) | 431.88 (±198.14) | 373.94 (±170.94) | 200–400 | 0.095 |
| Factor II (%) | 57.46 (±15.12) | 57.07 (±14.73) | 70–120 | 0.888 |
| Factor V (%) | 54.35(±19.13) | 52.70 (±18.10) | 70–120 | 0.635 |
| Factor VII (%) | 36.33(±13.78) | 37.61(±15.54) | 55–165 | 0.638 |
| Factor X (%) | 56.34(±16.40) | 54.67(±15.62) | 70–120 | 0.579 |
| AT (%) | 65.44(±17.85) | 68.25(±14.45) | 80–120 | 0.389 |
| PC (%) | 58.98(±11.94) | 60.06(±13.71) | 70–150 | 0.663 |
| PS (%) | 44.86(±10.08) | 43.68(±12.04) | 60–140 | 0.581 |
| D-dimer (ng/mL) | 4830.5 (6273) | 3940 (7493) | <500 | 0.446 |
| EXTEM CT (s) | 69 (20.5) | 70.5 (22.8) | 38–79 | 0.791 |
| EXTEM CFT (s) | 90.5 (80) | 114.5 (104) | 34–159 | 0.001 |
| EXTEM MCF (mm) | 64.30(±14.41) | 56.71(±12.60) | 50–72 | 0.004 |
| EXTEM MCE | 218.81(±126.33) | 147.85(±73.31) | - | 0.001 |
| EXTEM CLI60 (%) | 98(3) | 98(4) | >85 | 0.167 |
| MaxVel (mm/min) | 17 (9.8) | 14 (10) | 11–25 |
0.021 |
| t-MaxVel (s) | 85 (69.5) | 99 (105.5) | 147–223 |
0.931 |
| AUC (mm x 100) | 6360.16(±1364.86) | 5602.31(±1269.07) | - | 0.005 |
| FIBTEM MCF (mm) | 21.71(±11.40) | 16.40(±7.78) | 9–25 | 0.007 |
| FIBTEM MCE | 38.44 (±53.24) | 20.66 (±13.23) | - | 0.024 |
| APTEM CLI60 (%) | 98 (3) | 98 (4) | - | 0.278 |
| Diff CLI60 | 0 (0) | 0 (1) | - | 0.374 |
| Platelet component | 175.5 (156.75) | 119.5 (105) | - | 0.010 |