The Correlation of Hemostatic Parameters with the Development of Early Sepsis-Associated Encephalopathy. A Retrospective Observational Study
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31. Okt. 2024
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Artikel-Kategorie: Research Article
Online veröffentlicht: 31. Okt. 2024
Seitenbereich: 329 - 336
Eingereicht: 28. Feb. 2024
Akzeptiert: 28. Sept. 2024
DOI: https://doi.org/10.2478/jccm-2024-0040
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© 2024 Florin Scarlatescu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Fig. 1.
Fig. 2.
Fig. 3.
Multivariate logistic regression model using age and complete blood count parameters_
| Leucocyte count | 1.000 | 1.000; 1.000 | 0.403 |
| Platelet count | 1.003 | 1.001; 1.006 | 0.004 |
| Age | 1.003 | 0.987; 1.020 | 0.710 |
Demographic data and complete blood count parameters in patients with and without sepsis-associated encephalopathy (SAE)_
| Age (years) | 73 (18) | 70 (16) | 0.088 | |
| Male sex | 94 (51.08%) | 52 (54.16%) | 0.624 | |
| Leucocyte count (per μL) | 14100 (10960) | 10265 (10882) | 4000–9000 | 0.003 |
| Hemoglobin (g/dL) | 10.1 (3.9) | 9.8 (3.8) | 11.5–17 | 0.276 |
| Platelet count (per μL) | 200000 (166500) | 128500 (149500) | 150000–400000 | <0.001 |
Multivariate logistic regression model using fibrinogen levels and platelet contribution to clot strength_
| Fibrinogen level | 1.000 | 0.997; 1.002 | 0.403 |
| Platelet component | 1.007 | 1.001; 1.013 | 0.02 |
Hemostatic tests in patients with and without sepsis-associated encephalopathy (SAE)_
| PT (s) | 15.95 (3.8) | 17 (5.2) | 10.4–14.3 | 0.440 |
| Fibrinogen (mg/dL) | 431.88 (±198.14) | 373.94 (±170.94) | 200–400 | 0.095 |
| Factor II (%) | 57.46 (±15.12) | 57.07 (±14.73) | 70–120 | 0.888 |
| Factor V (%) | 54.35(±19.13) | 52.70 (±18.10) | 70–120 | 0.635 |
| Factor VII (%) | 36.33(±13.78) | 37.61(±15.54) | 55–165 | 0.638 |
| Factor X (%) | 56.34(±16.40) | 54.67(±15.62) | 70–120 | 0.579 |
| AT (%) | 65.44(±17.85) | 68.25(±14.45) | 80–120 | 0.389 |
| PC (%) | 58.98(±11.94) | 60.06(±13.71) | 70–150 | 0.663 |
| PS (%) | 44.86(±10.08) | 43.68(±12.04) | 60–140 | 0.581 |
| D-dimer (ng/mL) | 4830.5 (6273) | 3940 (7493) | <500 | 0.446 |
| EXTEM CT (s) | 69 (20.5) | 70.5 (22.8) | 38–79 | 0.791 |
| EXTEM CFT (s) | 90.5 (80) | 114.5 (104) | 34–159 | 0.001 |
| EXTEM MCF (mm) | 64.30(±14.41) | 56.71(±12.60) | 50–72 | 0.004 |
| EXTEM MCE | 218.81(±126.33) | 147.85(±73.31) | - | 0.001 |
| EXTEM CLI60 (%) | 98(3) | 98(4) | >85 | 0.167 |
| MaxVel (mm/min) | 17 (9.8) | 14 (10) | 11–25 |
0.021 |
| t-MaxVel (s) | 85 (69.5) | 99 (105.5) | 147–223 |
0.931 |
| AUC (mm x 100) | 6360.16(±1364.86) | 5602.31(±1269.07) | - | 0.005 |
| FIBTEM MCF (mm) | 21.71(±11.40) | 16.40(±7.78) | 9–25 | 0.007 |
| FIBTEM MCE | 38.44 (±53.24) | 20.66 (±13.23) | - | 0.024 |
| APTEM CLI60 (%) | 98 (3) | 98 (4) | - | 0.278 |
| Diff CLI60 | 0 (0) | 0 (1) | - | 0.374 |
| Platelet component | 175.5 (156.75) | 119.5 (105) | - | 0.010 |