Clinical Characteristics and Outcomes of COVID-19 Acute Respiratory Distress Syndrome Patients Requiring Invasive Mechanical Ventilation in a Lower Middle-Income Country

1WHO. Weekly Operational Update on COVID-19-1 March 2021. World Heal Organ [Internet]. 2021;(March):1–10. WHO. Weekly Operational Update on COVID-19-1 March 2021. World Heal Organ [Internet] 2021 (March) 1–10Search in Google Scholar

2Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA - J Am Med Assoc. 2020;323(13):1239–42. Wu Z McGoogan JM Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention JAMA - J Am Med Assoc 2020323 13 1239 4210.1001/jama.2020.2648Search in Google Scholar

3Wunsch H. Mechanical ventilation in COVID-19: Interpreting the current epidemiology. Am J Respir Crit Care Med. 2020;202(1):1–4. Wunsch H Mechanical ventilation in COVID-19: Interpreting the current epidemiology Am J Respir Crit Care Med 2020202 1 1 410.1164/rccm.202004-1385EDSearch in Google Scholar

4Wu C, Chen X, Cai Y, et al. Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934–43. Wu C Chen X Cai Y et al Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China JAMA Intern Med 2020180 7 934 4310.1001/jamainternmed.2020.0994Search in Google Scholar

5ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA [Internet]. 2012 20th June;307(23):2526–33. ARDS Definition Task Force Ranieri VM Rubenfeld GD et al Acute respiratory distress syndrome: the Berlin Definition JAMA [Internet] 2012 20th June307 23 2526 3310.1001/jama.2012.5669Search in Google Scholar

6Fan E, Beitler JR, Brochard L, et al. COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? Lancet Respir Med [Internet]. 2020;8(8):816–21. Fan E Beitler JR Brochard L et al COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? Lancet Respir Med [Internet] 20208 8 816 2110.1016/S2213-2600(20)30304-0Search in Google Scholar

7Gatinoni L, Coppola S, Cressoni M, Busana M, Rossi S, Chiumello D. COVID-19 does not lead to a “typical” acute respiratory distress syndrome. Am J Respir Crit Care Med. 2020;201(10):1299–300. Gatinoni L Coppola S Cressoni M Busana M Rossi S Chiumello D COVID-19 does not lead to a “typical” acute respiratory distress syndrome Am J Respir Crit Care Med 2020201 10 1299 30010.1164/rccm.202003-0817LE723335232228035Search in Google Scholar

8Marini JJ, GatinonI L. Management ofCOVID-19 Respiratory Distress. JAMA -J Am Med Assoc. 2020;323(22). Marini JJ GatinonI L Management ofCOVID-19 Respiratory Distress JAMA -J Am Med Assoc 2020323 22 10.1001/jama.2020.682532329799Search in Google Scholar

9Grasselli G, Greco M, Zanella A, et al. Risk Factors Associated with Mortality among Patients with COVID-19 in Intensive Care Units in Lombardy, Italy. JAMA Intern Med. 2020;180(10):1345– 55. Grasselli G Greco M Zanella A et al Risk Factors Associated with Mortality among Patients with COVID-19 in Intensive Care Units in Lombardy, Italy JAMA Intern Med 2020180 10 1345– 5510.1001/jamainternmed.2020.3539736437132667669Search in Google Scholar

10Asghar MS, Haider Kazmi SJ, Ahmed Khan N, et al. Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of KarachiCorrection. Cureus. 2020;12(6). Asghar MS Haider Kazmi SJ Ahmed Khan N et al Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of KarachiCorrection Cureus 202012 6 10.7759/cureus.c34741128632782891Search in Google Scholar

11Baqi S, Naz A, Sayeed MA, et al. Clinical Characteristics and Outcome of Patients With Severe COVID-19 Pneumonia at a Public Sector Hospital in Karachi, Pakistan. Cureus. 2021;13(2):1–13. Baqi S Naz A Sayeed MA et al Clinical Characteristics and Outcome of Patients With Severe COVID-19 Pneumonia at a Public Sector Hospital in Karachi, Pakistan Cureus 202113 2 1 1310.7759/cureus.13107793507633728127Search in Google Scholar

12Sarfaraz S, Shaikh Q, Saleem SG, Rahim A, Farooq F. Determinants of in-hospital mortality in COVID-19 ; a prospective cohort study from Pakistan 1-Samreen Sarfaraz , FRCP ( Glasg ) Infectious Disease Department, The Indus Hospital , Karachi 2- Quratulain Shaikh, FCPS, MSc Indus Hospital Research Centre. 2021; Sarfaraz S Shaikh Q Saleem SG Rahim A Farooq F Determinants of in-hospital mortality in COVID-19 ; a prospective cohort study from Pakistan 1-Samreen Sarfaraz , FRCP ( Glasg ) Infectious Disease Department The Indus Hospital Karachi 2- Quratulain Shaikh, FCPS, MSc Indus Hospital Research Centre. 202110.1101/2020.12.28.20248920Search in Google Scholar

13Vincent J-L, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/ failure. Intensive Care Med [Internet]. 1996 1st July;22(7):707– 10. Vincent J-L Moreno R Takala J et al The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/ failure Intensive Care Med [Internet] 1996 1st July;22 7 707–1010.1007/BF01709751Search in Google Scholar

14Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med [Internet]. 1985 Oct;13(10):818–29. Knaus WA Draper EA Wagner DP Zimmerman JE APACHE II: a severity of disease classification system Crit Care Med [Internet] 1985 Oct13 10 818 2910.1097/00003246-198510000-00009Search in Google Scholar

15(KDIGO) KDIGO. Section 2: AKI Definition. Kidney Int Suppl [Internet]. 2012 Mar;2(1):19–36. (KDIGO) KDIGO Section 2: AKI Definition Kidney Int Suppl [Internet] 2012 Mar2 1 19 3610.1038/kisup.2011.32Search in Google Scholar

16Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA [Internet]. 2016 23rd February;315(8):801. Singer M Deutschman CS Seymour CW et al The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA [Internet] 2016 23rd February;315 8 80110.1001/jama.2016.0287Search in Google Scholar

17Kalil AC, Metersky ML, Klompas M, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis [Internet]. 2016 Sep 1;63(5):e61–111. Kalil AC Metersky ML Klompas M et al Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society Clin Infect Dis [Internet] 2016 Sep 1 63 5 e61 11110.1093/cid/ciw353Search in Google Scholar

18Lim ZJ, Subramaniam A, Ponnapa Reddy M, et al. Case Fatality Rates for Patients with COVID-19 Requiring Invasive Mechanical Ventilation. A Meta-analysis. Am J Respir Crit Care Med [Internet]. 2021 1st January;203(1):54–66. Lim ZJ Subramaniam A Ponnapa Reddy M et al Case Fatality Rates for Patients with COVID-19 Requiring Invasive Mechanical Ventilation A Meta-analysis. Am J Respir Crit Care Med [Internet] 2021 1st January203 1 54 6610.1164/rccm.202006-2405OCSearch in Google Scholar

19Quah P, Li A, Phua J. Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature. Crit Care [Internet]. 2020 4th December;24(1):285. Quah P Li A Phua J Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature Crit Care [Internet] 2020 4th December24 1 28510.1186/s13054-020-03006-1Search in Google Scholar

20Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet [Internet]. 2020 Mar;395(10229):1054–62. Zhou F Yu T Du R et al Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Lancet [Internet] 2020 Mar395 10229 1054 6210.1016/S0140-6736(20)30566-3Search in Google Scholar

21Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med [Internet]. 2020;8(5):475–81. Yang X Yu Y Xu J et al Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Lancet Respir Med [Internet] 20208 5 475 8110.1016/S2213-2600(20)30079-5Search in Google Scholar

22Wang Y, Lu X, Li Y, et al. Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19. Am J Respir Crit Care Med [Internet]. 2020 1st June;201(11):1430–4. Wang Y Lu X Li Y et al Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19 Am J Respir Crit Care Med [Internet] 2020 1st June201 11 1430 410.1164/rccm.202003-0736LE725863232267160Search in Google Scholar

23Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admited to ICUs of the Lombardy Region, Italy. JAMA - J Am Med Assoc. 2020;323(16):1574–81. Grasselli G Zangrillo A Zanella A et al Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admited to ICUs of the Lombardy Region, Italy JAMA - J Am Med Assoc 2020323 16 1574 8110.1001/jama.2020.5394713685532250385Search in Google Scholar

24Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalised with COVID-19 in the New York City Area. JAMA -J Am Med Assoc. 2020;323(20):2052–9. Richardson S Hirsch JS Narasimhan M et al Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalised with COVID-19 in the New York City Area JAMA -J Am Med Assoc 2020323 20 2052 910.1001/jama.2020.6775717762932320003Search in Google Scholar

25Gupta S, Hayek SS, Wang W, et al. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Intern Med [Internet]. 2020 Nov 1;180(11):1436. Gupta S Hayek SS Wang W et al Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US JAMA Intern Med [Internet] 2020 Nov 1180 11 143610.1001/jamainternmed.2020.3596736433832667668Search in Google Scholar

26ICNARC. ICNARC report on COVID-19 in critical care [Internet]. ICNARC COVID-19 Study Case Mix Programme Database. 2020. ICNARC ICNARC report on COVID-19 in critical care [Internet] ICNARC COVID-19 Study Case Mix Programme Database 2020Search in Google Scholar

27King CS, Sahjwani D, Brown AW, et al. Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure. Lazzeri C, editor. PLoS One [Internet]. 2020 Nov 23;15(11):e0242651. King CS Sahjwani D Brown AW et al Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure Lazzeri C, editor. PLoS One [Internet] 2020 Nov 2315 11 e024265110.1371/journal.pone.0242651768289933227024Search in Google Scholar

28Auld SC, Caridi-Scheible M, Blum JM, et al. ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019. Crit Care Med [Internet]. 2020 26th May; Publish Ah: E799–804. Auld SC Caridi-Scheible M Blum JM et al ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019 Crit Care Med [Internet] 2020 26th May; Publish Ah: E799–80410.1097/CCM.0000000000004457725539332452888Search in Google Scholar

29Søvik S, Bådstøløkken PM, Sørensen V, et al. A single‐centre, prospective cohort study of COVID‐19 patients admitted to ICU for mechanical ventilatory support. Acta Anaesthesiol Scand [Internet]. 2021 22nd March;65(3):351–9. Søvik S Bådstøløkken PM Sørensen V et al A single‐centre, prospective cohort study of COVID‐19 patients admitted to ICU for mechanical ventilatory support Acta Anaesthesiol Scand [Internet] 2021 22nd March65 3 351 910.1111/aas.13726789415233128800Search in Google Scholar

30Bellani G, Lafey JG, Pham T, et al. Epidemiology, Paterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA [Internet]. 2016 23rd February;315(8):788. Bellani G Lafey JG Pham T et al Epidemiology, Paterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries JAMA [Internet] 2016 23rd February315 8 78810.1001/jama.2016.029126903337Search in Google Scholar

31Ferrando C, Suarez-Sipmann F, Mellado-Artigas R, et al. Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Intensive Care Med [Internet]. 2020 29th December;46(12):2200–11. Ferrando C Suarez-Sipmann F Mellado-Artigas R et al Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS Intensive Care Med [Internet] 2020 29th December46 12 2200 1110.1007/s00134-020-06192-2738788432728965Search in Google Scholar

32Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA [Internet]. 2020 Mar 17;323(11):1061. Wang D Hu B Hu C et al Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China JAMA [Internet] 2020 Mar 17323 11 106110.1001/jama.2020.1585704288132031570Search in Google Scholar

33Cheng P, Wu H, Yang J, et al. pneumonia scoring systems for severe COVID-19: which one is better. Virol J [Internet]. 2021 Dec 10;18(1):33. Cheng P Wu H Yang J et al pneumonia scoring systems for severe COVID-19: which one is better Virol J [Internet] 2021 Dec 10;18 1 3310.1186/s12985-021-01502-6787499433568204Search in Google Scholar

34Zou X, Li S, Fang M, et al. Acute Physiology and Chronic Health Evaluation II Score as a Predictor of Hospital Mortality in Patients of Coronavirus Disease 2019. Crit Care Med [Internet]. 2020 1st August;48(8):e657–65. Zou X Li S Fang M et al Acute Physiology and Chronic Health Evaluation II Score as a Predictor of Hospital Mortality in Patients of Coronavirus Disease 2019 Crit Care Med [Internet] 2020 1st August48 8 e657 6510.1097/CCM.0000000000004411721712832697506Search in Google Scholar

35Isted A, McDonnell AJ, Jones E, et al. Clinical characteristics and outcomes of 85 intensive care patients with Covid-19 in South London: A single centre observational study. J Intensive Care Soc [Internet]. 2020 Nov 11;175114372097154. Isted A McDonnell AJ Jones E et al Clinical characteristics and outcomes of 85 intensive care patients with Covid-19 in South London: A single centre observational study J Intensive Care Soc [Internet] 2020 Nov 1117511437209715410.1177/1751143720971541Search in Google Scholar

36Hirsch JS, Ng JH, Ross DW, et al. Acute kidney injury in patients hospitalised with COVID-19. Kidney Int [Internet]. 2020 Jul;98(1):209–18. Hirsch JS Ng JH Ross DW et al Acute kidney injury in patients hospitalised with COVID-19 Kidney Int [Internet] 2020 Jul98 1 209 1810.1016/j.kint.2020.05.006722946332416116Search in Google Scholar

37Fominskiy E V., Scandroglio AM, Monti G, et al. Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy. Blood Purif [Internet]. 2021;50(1):102–9. Fominskiy E V. Scandroglio AM Monti G et al Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy Blood Purif [Internet] 202150 1 102 910.1159/000508657744537332659757Search in Google Scholar

38Thakkar J, Chand S, Aboodi MS, et al. Characteristics, Outcomes and 60-Day Hospital Mortality of ICU Patients with COVID-19 and Acute Kidney Injury. Kidney360 [Internet]. 2020 31st December;1(12):1339–44. Thakkar J Chand S Aboodi MS et al Characteristics, Outcomes and 60-Day Hospital Mortality of ICU Patients with COVID-19 and Acute Kidney Injury Kidney360 [Internet] 2020 31st December1 12 1339 4410.34067/KID.0004282020881552235372894Search in Google Scholar

39Thapa SB, Kakar TS, Mayer C, Khanal D. Clinical Outcomes of In-Hospital Cardiac Arrest in COVID-19. JAMA Intern Med [Internet]. 2021 Feb 1;181(2):279. Thapa SB Kakar TS Mayer C Khanal D Clinical Outcomes of In-Hospital Cardiac Arrest in COVID-19 JAMA Intern Med [Internet] 2021 Feb 1181 2 27910.1001/jamainternmed.2020.4796752277232986117Search in Google Scholar

40Sheth V, Chishti I, Rothman A, et al. Outcomes of in-hospital cardiac arrest in patients with COVID-19 in New York City. Resuscitation [Internet]. 2020 Oct;155(January):3–5. Sheth V Chishti I Rothman A et al Outcomes of in-hospital cardiac arrest in patients with COVID-19 in New York City Resuscitation [Internet] 2020 Oct155 January 3 510.1016/j.resuscitation.2020.07.011737226332707146Search in Google Scholar

41Shao F, Xu S, Ma X, et al. In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan, China. Resuscitation [Internet]. 2020 Jun;151:18–23. Shao F Xu S Ma X et al In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan, China Resuscitation [Internet] 2020 Jun15118 2310.1016/j.resuscitation.2020.04.005715154332283117Search in Google Scholar

42Hayek SS, Brenner SK, Azam TU, et al. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ [Internet]. 2020 Sep 30;371:m3513. Hayek SS Brenner SK Azam TU et al In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study BMJ [Internet] 2020 Sep 30;371m351310.1136/bmj.m3513752534232998872Search in Google Scholar