Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View
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Aug 09, 2019
About this article
Article Category: Review
Published Online: Aug 09, 2019
Page range: 90 - 96
Received: Apr 14, 2019
Accepted: Jul 29, 2019
DOI: https://doi.org/10.2478/jccm-2019-0017
Keywords
© 2019 Alexandra Lazăr, Anca Meda Georgescu, Alexander Vitin, Leonard Azamfirei, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Fig. 1
Table of Pharmacogenomic Biomarkers in Drug Labeling (10)
| Medical area | Drug | Biomarker |
|---|---|---|
| Infectious | Abacavir | HLA-B |
| Diseases | Boceprevir | IFNL3 (IL28B)- genetic variant near the gene encoding interferon-lambda-3 |
| Ceftriaxone | G6PD | |
| Daclatasvir | IFNL3 (IL28B) | |
| Efavirenz | CYP2B6 | |
| Oncology | Abemaciclib (1) | ESR (HR)-hormone receptor |
| Abemaciclib (2) | ERBB2 (HER2)- , human epidermal growth factor receptor 2 | |
| ERBB2 (HER2) | ||
| Ado-Trastuzumab Emtansine | EGFR (epidermal growth factor receptor) | |
| Afatinib | ALK (anaplastic lymphoma kinase) | |
| Alectinib | CD274 (PD-L1) | |
| Atezolizumab (1) | Gene Signature (T-effector) | |
| Atezolizumab (2) | ROS | |
| Crizotinib | BRAF | |
| Dabrafenib | RAS | |
| Dabrafenib | ESR, PGR (Hormone Receptor) | |
| Docetaxel | CD274 (PD-L1) | |
| Durvalumab | Chromosome 17p | |
| Duvelisib | FLT3 | |
| Gilteritinib | Chromosome 11q | |
| Ibrutinib | BCR-ABL1 (Philadelphia chromosome) | |
| Inotuzumab Ozogamicin | Microsatellite Instability Mismatch Repair | |
| Ipilimumab | IDH1- isocitrate dehydrogenase-1 | |
| Ivosidenib | HLA-DQA1, HLA-DRB1 | |
| Lapatinib | NTRK- gene | |
| Larotrectinib | NUDT15- nucleotide diphosphatase | |
| Mercaptopurine | UGT1A1-polymorphysm | |
| Neurology | Amifampridine | NAT2 (N-acetyltransferase 2) |
| Citalopram | CYP2C19 | |
| Inotersen | TTR | |
| Nusinersen | Nusinersen | |
| Psychiatry | Amphetamine | CYP2D6 |
| Clozapine | CYP2D6 | |
| Anesthesiology | Articaine and Epinephrine (1) | G6PD |
| Chloroprocaine | G6PD | |
| Codeine | CYP2D | |
| Lidocaine and Tetracaine | G6PD | |
| Lofexidine | CYP2D6 | |
| Mivacurium | BCHE | |
| Hematology | Avatrombopag (1) | F2 (Prothrombin) |
| Avatrombopag (2) | F5 (Factor V Leiden) | |
| Avatrombopag (3) | SERPINC1 (Antithrombin III) | |
| Blinatumomab | BCR-ABL1 (Philadelphia chromosome) | |
| Emapalumab-lzsg | PRF1, RAB27A, SH2D1A, STXBP2, STX11, UNC13D, XIAP (Hemophagocy tic Lymphohistiocytosis)- | |
| Enasidenib | IDH2 | |
| Lenalidomide | Chromosome 5q | |
| Lusutrombopag | PROC, SERPINC1 (Antithrombin III) | |
| Inborn Errors of Metabolism | Cerliponase Alfa | TPP1- tripeptidyl peptidase 1 |
| Eliglustat | CYP2D6 | |
| Migalastat | GLA- galactosidase alpha gene | |
| Urology | Fesoterodine | CYP2D6 |
| Tolterodine | CYP2D6 | |
| Pulmonary | Formoterol | CYP2D6 |
| CYP2C19 | ||
| Ivacaftor | CFTR- cystic fibrosis transmembrane conductance regulator | |
| Gynecology | Ospemifene | CYP2C9 |