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α-Glucosidase inhibitory fatty acids from Morchella fluvialis mushroom

Ayman Turk

Ayman Turk

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Turk, Ayman
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Solip Lee

Solip Lee

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Lee, Solip
, 
Hak Hyun Lee

Hak Hyun Lee

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Lee, Hak Hyun
, 
Sang Won Yeon

Sang Won Yeon

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Yeon, Sang Won
, 
Se Hwan Ryu

Se Hwan Ryu

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Ryu, Se Hwan
, 
Geum Hee Seo

Geum Hee Seo

Department of Mushroom Science, Korea National College of Agriculture and FisheriesJeonju, South Korea
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Seo, Geum Hee
, 
Hyun You Chang

Hyun You Chang

Department of Mushroom Science, Korea National College of Agriculture and FisheriesJeonju, South Korea
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Chang, Hyun You
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Bang Yeon Hwang

Bang Yeon Hwang

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Hwang, Bang Yeon
 and 
Mi Kyeong Lee

Mi Kyeong Lee

Lab of Pharmacognosy, College of Pharmacy, Chungbuk National UniversityCheongju, South Korea
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Lee, Mi Kyeong
  
Dec 31, 2023
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Article Category: SHORT COMMUNICATION
Published Online: Dec 31, 2023
Page range: 369 - 379
Received: Feb 17, 2023
Accepted: Aug 04, 2023
DOI: https://doi.org/10.2478/fhort-2023-0026
Keywords
© 2023 Ayman Turk et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

Characterisation of Morchella fluvialis. Phylogenetic analysis was conducted based on ITS1 and ITS4 sequence data. The length of the branches corresponds to the cumulative number of nucleotide substitutions in the DNA sequences under analysis. The sequences were obtained from GeneBank and EMBL databases, and their corresponding accession numbers are given within brackets.
Characterisation of Morchella fluvialis. Phylogenetic analysis was conducted based on ITS1 and ITS4 sequence data. The length of the branches corresponds to the cumulative number of nucleotide substitutions in the DNA sequences under analysis. The sequences were obtained from GeneBank and EMBL databases, and their corresponding accession numbers are given within brackets.

Figure 2.

Effects of total extract and different fractions of M. fluvialis on α-glucosidase inhibitory and antioxidant activities. All data are presented as mean ± SEM (n = 3). *p < 0.05 and **p < 0.01, ***p < 0.001 indicates significant differences compared to the control group.
Effects of total extract and different fractions of M. fluvialis on α-glucosidase inhibitory and antioxidant activities. All data are presented as mean ± SEM (n = 3). *p < 0.05 and **p < 0.01, ***p < 0.001 indicates significant differences compared to the control group.

Figure 3.

Chemical structures of compounds 1–9 isolated from M. fluvialis.
Chemical structures of compounds 1–9 isolated from M. fluvialis.

Figure 4.

[A] HPLC chromatogram and [B] amount of compound 1 of total extract and different fractions of M. fluvialis.
[A] HPLC chromatogram and [B] amount of compound 1 of total extract and different fractions of M. fluvialis.

Supplementary Scheme S1.

Extraction and isolation of sterols.
Extraction and isolation of sterols.

Supplementary Figure S1.

1H NMR spectrum of compound 1 (CDCl3, 500 MHz).
1H NMR spectrum of compound 1 (CDCl3, 500 MHz).

Supplementary Figure S2.

13C NMR spectrum of compound 1 (CDCl3, 125 MHz).
13C NMR spectrum of compound 1 (CDCl3, 125 MHz).

Supplementary Figure S3.

1H NMR spectrum of compound 2 (CDCl3, 500 MHz).
1H NMR spectrum of compound 2 (CDCl3, 500 MHz).

Supplementary Figure S4.

13C NMR spectrum of compound 2 (CDCl3, 125 MHz).
13C NMR spectrum of compound 2 (CDCl3, 125 MHz).

Supplementary Figure S5.

1H NMR spectrum of compound 3 (CDCl3, 500 MHz).
1H NMR spectrum of compound 3 (CDCl3, 500 MHz).

Supplementary Figure S6.

13C NMR spectrum of compound 3 (CDCl3, 125 MHz).
13C NMR spectrum of compound 3 (CDCl3, 125 MHz).

α-Glucosidase inhibitory activity of compounds 1–6 from M_ fluvialis_

Compound α-Glucosidase inhibitory activity (100 μM) IC50 (μM)
1 89.2 ± 3.4 14.8
2 53.1 ± 6.3 95.2
3 32.8 ± 6.6 >100
4 24.8 ± 6.5 >100
5 21.9 ± 0.3 >100
6 17.0 ± 0.3 >100
Acarbose* 76.4 ± 3.4 72.5
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