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α-Glucosidase inhibitory fatty acids from Morchella fluvialis mushroom

Ayman Turk
Ayman Turk
, 
Solip Lee
Solip Lee
, 
Hak Hyun Lee
Hak Hyun Lee
, 
Sang Won Yeon
Sang Won Yeon
, 
Se Hwan Ryu
Se Hwan Ryu
, 
Geum Hee Seo
Geum Hee Seo
, 
Hyun You Chang
Hyun You Chang
, 
Bang Yeon Hwang
Bang Yeon Hwang
 und 
Mi Kyeong Lee
Mi Kyeong Lee
   | 31. Dez. 2023
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Article Category: SHORT COMMUNICATION
Online veröffentlicht: 31. Dez. 2023
Seitenbereich: 369 - 379
Eingereicht: 17. Feb. 2023
Akzeptiert: 04. Aug. 2023
DOI: https://doi.org/10.2478/fhort-2023-0026
Schlüsselwörter
© 2023 Ayman Turk et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

Characterisation of Morchella fluvialis. Phylogenetic analysis was conducted based on ITS1 and ITS4 sequence data. The length of the branches corresponds to the cumulative number of nucleotide substitutions in the DNA sequences under analysis. The sequences were obtained from GeneBank and EMBL databases, and their corresponding accession numbers are given within brackets.
Characterisation of Morchella fluvialis. Phylogenetic analysis was conducted based on ITS1 and ITS4 sequence data. The length of the branches corresponds to the cumulative number of nucleotide substitutions in the DNA sequences under analysis. The sequences were obtained from GeneBank and EMBL databases, and their corresponding accession numbers are given within brackets.

Figure 2.

Effects of total extract and different fractions of M. fluvialis on α-glucosidase inhibitory and antioxidant activities. All data are presented as mean ± SEM (n = 3). *p < 0.05 and **p < 0.01, ***p < 0.001 indicates significant differences compared to the control group.
Effects of total extract and different fractions of M. fluvialis on α-glucosidase inhibitory and antioxidant activities. All data are presented as mean ± SEM (n = 3). *p < 0.05 and **p < 0.01, ***p < 0.001 indicates significant differences compared to the control group.

Figure 3.

Chemical structures of compounds 1–9 isolated from M. fluvialis.
Chemical structures of compounds 1–9 isolated from M. fluvialis.

Figure 4.

[A] HPLC chromatogram and [B] amount of compound 1 of total extract and different fractions of M. fluvialis.
[A] HPLC chromatogram and [B] amount of compound 1 of total extract and different fractions of M. fluvialis.

Supplementary Scheme S1.

Extraction and isolation of sterols.
Extraction and isolation of sterols.

Supplementary Figure S1.

1H NMR spectrum of compound 1 (CDCl3, 500 MHz).
1H NMR spectrum of compound 1 (CDCl3, 500 MHz).

Supplementary Figure S2.

13C NMR spectrum of compound 1 (CDCl3, 125 MHz).
13C NMR spectrum of compound 1 (CDCl3, 125 MHz).

Supplementary Figure S3.

1H NMR spectrum of compound 2 (CDCl3, 500 MHz).
1H NMR spectrum of compound 2 (CDCl3, 500 MHz).

Supplementary Figure S4.

13C NMR spectrum of compound 2 (CDCl3, 125 MHz).
13C NMR spectrum of compound 2 (CDCl3, 125 MHz).

Supplementary Figure S5.

1H NMR spectrum of compound 3 (CDCl3, 500 MHz).
1H NMR spectrum of compound 3 (CDCl3, 500 MHz).

Supplementary Figure S6.

13C NMR spectrum of compound 3 (CDCl3, 125 MHz).
13C NMR spectrum of compound 3 (CDCl3, 125 MHz).

α-Glucosidase inhibitory activity of compounds 1–6 from M. fluvialis.

Compound α-Glucosidase inhibitory activity (100 μM) IC50 (μM)
1 89.2 ± 3.4 14.8
2 53.1 ± 6.3 95.2
3 32.8 ± 6.6 >100
4 24.8 ± 6.5 >100
5 21.9 ± 0.3 >100
6 17.0 ± 0.3 >100
Acarbose* 76.4 ± 3.4 72.5
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