<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this work was to optimize the mass ratio of three <italic>Curcuma</italic> plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected <italic>Curcuma</italic> plants were <italic>C. longa</italic>, <italic>C. zedoaria</italic> and <italic>C. aromatica</italic>. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. <italic>Curcuma longa</italic> alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of <italic>C. longa</italic> and <italic>C. aromatica</italic> in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that <italic>C. longa</italic> alone exhibited the highest antioxidant activity.</p></abstract>

The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity.

Simplex lattice design for optimization of the mass ratio of <italic>Curcuma longa</italic> L., <italic>Curcuma zedoaria</italic> (Christm.) Roscoe and <italic>Curcuma aromatica</italic> Salisb. to maximize curcuminoids content and antioxidant activity

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Simplex lattice design for optimization of the mass ratio of  L.,  (Christm.) Roscoe and  Salisb. to maximize curcuminoids content and antioxidant activity

The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using...

Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

Published Online: Dec 31, 2020

Page range: 445 - 457

Accepted: Aug 15, 2020

DOI: https://doi.org/10.2478/acph-2021-0025

Keywords
curcuminoids, HPLC, simplex lattice design, optimization, antioxidant activity

© 2021 Chaowalit Monton et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

Published Online: Dec 31, 2020

Page range: 445 - 457

Accepted: Aug 15, 2020

DOI: https://doi.org/10.2478/acph-2021-0025

Keywordscurcuminoids, HPLC, simplex lattice design, optimization, antioxidant activity

© 2021 Chaowalit Monton et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
curcuminoids, HPLC, simplex lattice design, optimization, antioxidant activity